STRINGSTRING
MBP MBP NTF3 NTF3 GPX4 GPX4 PTBP1 PTBP1 LHX3 LHX3 TREM2 TREM2 IL10 IL10 DLK1 DLK1 ATG5 ATG5 GDNF GDNF SNPH SNPH OLIG2 OLIG2 NOTCH1 NOTCH1 MMP9 MMP9 NEUROG2 NEUROG2 CD68 CD68 CD63 CD63 PDGFRB PDGFRB PTEN PTEN NEUROD1 NEUROD1 MYT1L MYT1L FGF2 FGF2 OMG OMG MYRF MYRF ASCL1 ASCL1 ZIC1 ZIC1 CD9 CD9 CD40 CD40 IL4 IL4 IL13 IL13 CSF3 CSF3 CCL2 CCL2 IL1B IL1B IL18 IL18 CD81 CD81 MTOR MTOR CYCS CYCS SOX9 SOX9 FOXJ1 FOXJ1 FIS1 FIS1 CASP3 CASP3 BAK1 BAK1 CASP1 CASP1 CCL3 CCL3 PDGFB PDGFB IFNG IFNG SHOX2 SHOX2 CLDN15 CLDN15 MAP1LC3B MAP1LC3B ISL1 ISL1 CX3CR1 CX3CR1 IRF4 IRF4 STAT6 STAT6 BDNF BDNF STAT1 STAT1 BECN1 BECN1 HIF1A HIF1A CASP12 CASP12 DCX DCX IL6 IL6 MFN2 MFN2 NGF NGF PIK3C3 PIK3C3 GFAP GFAP RHOA RHOA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MBPMyelin basic protein. (437 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
PTBP1Polypyrimidine tract binding protein 1. (558 aa)
LHX3LIM homeobox 3. (402 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (291 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
DLK1Delta like non-canonical Notch ligand 1. (399 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (317 aa)
GDNFGlial cell derived neurotrophic factor. (342 aa)
SNPHSyntaphilin. (527 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
NOTCH1Notch receptor 1. (2556 aa)
MMP9Uncharacterized protein. (707 aa)
NEUROG2BHLH domain-containing protein. (272 aa)
CD68CD68 molecule. (354 aa)
CD63Tetraspanin. (238 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PTENUncharacterized protein. (589 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
MYT1LMyelin transcription factor 1-like protein. (1185 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
OMGOligodendrocyte-myelin glycoprotein. (440 aa)
MYRFUncharacterized protein. (1146 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (238 aa)
ZIC1Zic family member 1. (447 aa)
CD9Tetraspanin. (228 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
CSF3Colony stimulating factor 3. (207 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (185 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CD81Tetraspanin. (274 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
FOXJ1Forkhead box J1. (421 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (148 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
BAK1Uncharacterized protein. (261 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (462 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity). (92 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
SHOX2Short stature homeobox 2. (355 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
MAP1LC3BMicrotubule-associated proteins 1A/1B light chain 3B. (125 aa)
ISL1ISL LIM homeobox 1. (413 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
IRF4Interferon regulatory factor 4 isoform 1. (451 aa)
STAT6Signal transducer and activator of transcription. (902 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
BECN1Beclin 1. (507 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
CASP12Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution; Belongs to the peptidase C14A family. (430 aa)
DCXDoublecortin. (387 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
MFN2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (908 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
RHOARas homolog family member A. (209 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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