STRINGSTRING
LOC717686 LOC717686 CCL2 CCL2 GPR15 GPR15 CALML5 CALML5 CXCR3 CXCR3 CALML6 CALML6 GRK2 GRK2 CALML3 CALML3 MYLK2 MYLK2 RHO RHO EEA1 EEA1 CXCR4 CXCR4 ARRB2 ARRB2 CCR2 CCR2 CCR1 CCR1 CALM2 CALM2 CALM3 CALM3 ARRB1 ARRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC717686Uncharacterized protein; Belongs to the calmodulin family. (105 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (185 aa)
GPR15G-protein coupled receptor 15; Probable chemokine receptor. SIV-1 coreceptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CALML5Calmodulin-like protein 5. (146 aa)
CXCR3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CALML6Calmodulin like 6. (181 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
RHORhodopsin. (348 aa)
EEA1Early endosome antigen 1. (1453 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (382 aa)
ARRB2Arrestin beta 2. (575 aa)
CCR2C-C chemokine receptor type 2; Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity) Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similari [...] (360 aa)
CCR1C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. (355 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
ARRB1Arrestin beta 1. (529 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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