node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | CALM2 | ENSMMUP00000059263 | ENSMMUP00000076065 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Uncharacterized protein; Belongs to the calmodulin family. | 0.623 |
BDNF | CALM3 | ENSMMUP00000059263 | ENSMMUP00000076991 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Calmodulin 3; Belongs to the calmodulin family. | 0.623 |
BDNF | CALML3 | ENSMMUP00000059263 | ENSMMUP00000053471 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Calmodulin-related protein NB-1; Belongs to the calmodulin family. | 0.622 |
BDNF | CALML5 | ENSMMUP00000059263 | ENSMMUP00000022969 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Calmodulin-like protein 5. | 0.623 |
BDNF | CALML6 | ENSMMUP00000059263 | ENSMMUP00000045683 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Calmodulin like 6. | 0.632 |
BDNF | CCK | ENSMMUP00000059263 | ENSMMUP00000001437 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Cholecystokinin preproprotein. | 0.493 |
BDNF | HTR2A | ENSMMUP00000059263 | ENSMMUP00000036319 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] | 0.729 |
BDNF | LEP | ENSMMUP00000059263 | ENSMMUP00000007035 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.599 |
BDNF | LOC717686 | ENSMMUP00000059263 | ENSMMUP00000045604 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Uncharacterized protein; Belongs to the calmodulin family. | 0.623 |
BDNF | OXTR | ENSMMUP00000059263 | ENSMMUP00000064448 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | 0.509 |
BDNF | SLC6A4 | ENSMMUP00000059263 | ENSMMUP00000004679 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. | 0.825 |
CALM2 | BDNF | ENSMMUP00000076065 | ENSMMUP00000059263 | Uncharacterized protein; Belongs to the calmodulin family. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.623 |
CALM2 | CALM3 | ENSMMUP00000076065 | ENSMMUP00000076991 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin 3; Belongs to the calmodulin family. | 0.904 |
CALM2 | CALML3 | ENSMMUP00000076065 | ENSMMUP00000053471 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin-related protein NB-1; Belongs to the calmodulin family. | 0.902 |
CALM2 | CALML5 | ENSMMUP00000076065 | ENSMMUP00000022969 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin-like protein 5. | 0.908 |
CALM2 | CALML6 | ENSMMUP00000076065 | ENSMMUP00000045683 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin like 6. | 0.904 |
CALM3 | BDNF | ENSMMUP00000076991 | ENSMMUP00000059263 | Calmodulin 3; Belongs to the calmodulin family. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.623 |
CALM3 | CALM2 | ENSMMUP00000076991 | ENSMMUP00000076065 | Calmodulin 3; Belongs to the calmodulin family. | Uncharacterized protein; Belongs to the calmodulin family. | 0.904 |
CALM3 | CALML3 | ENSMMUP00000076991 | ENSMMUP00000053471 | Calmodulin 3; Belongs to the calmodulin family. | Calmodulin-related protein NB-1; Belongs to the calmodulin family. | 0.901 |
CALM3 | CALML5 | ENSMMUP00000076991 | ENSMMUP00000022969 | Calmodulin 3; Belongs to the calmodulin family. | Calmodulin-like protein 5. | 0.904 |