(45 nodes) (2022) The Role of RKIP in the Regulation of EMT in the Tumor Microenvironment. network (Macaca mulatta)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	LOC114674161	Galectin. (136 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	EGFR	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
	RHOA	Ras homolog family member A. (209 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	STAT3	Signal transducer and activator of transcription. (871 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1126 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	YY1	Transcriptional repressor protein YY1. (414 aa)
	E2F4	Transcription factor E2F4. (416 aa)
	VASP	Vasodilator stimulated phosphoprotein. (428 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
	VCL	Vinculin. (1134 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
	TWIST2	BHLH domain-containing protein. (160 aa)
	BACH1	Uncharacterized protein. (763 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	FBXL5	F-box and leucine rich repeat protein 5. (765 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (559 aa)
	ETS2	Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
	PTEN	Uncharacterized protein. (589 aa)
	ILK	Integrin-linked protein kinase. (452 aa)
	LAMB1	Laminin subunit beta 1. (1786 aa)
	COPS5	COP9 signalosome complex subunit 5. (334 aa)
	ABI1	Abl interactor 1 isoform a. (508 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	BMI1	RING-type domain-containing protein. (469 aa)
	LAMA4	Laminin subunit alpha 4. (1832 aa)
	SP1	Uncharacterized protein. (845 aa)
	ARG2	Arginase. (417 aa)
	GATA6	Transcription factor GATA-6. (595 aa)
	NECTIN1	Poliovirus receptor-related protein 1 isoform 1. (519 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	LOC694781	Galectin. (136 aa)
	USP51	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (756 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	SRC	ENSMMUP00000006731	ENSMMUP00000026506	Abl interactor 1 isoform a.	Tyrosine-protein kinase.	0.637
ABI1	VASP	ENSMMUP00000006731	ENSMMUP00000031567	Abl interactor 1 isoform a.	Vasodilator stimulated phosphoprotein.	0.498
AR	EGFR	ENSMMUP00000015004	ENSMMUP00000046120	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.693
AR	EZH2	ENSMMUP00000015004	ENSMMUP00000060546	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.744
AR	HDAC1	ENSMMUP00000015004	ENSMMUP00000013015	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.785
AR	HDAC2	ENSMMUP00000015004	ENSMMUP00000057724	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.567
AR	HDAC3	ENSMMUP00000015004	ENSMMUP00000033970	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.405
AR	PTEN	ENSMMUP00000015004	ENSMMUP00000011055	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Uncharacterized protein.	0.642
AR	SMAD3	ENSMMUP00000015004	ENSMMUP00000041841	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Mothers against decapentaplegic homolog.	0.627
AR	SMAD4	ENSMMUP00000015004	ENSMMUP00000024106	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Mothers against decapentaplegic homolog.	0.493
AR	SP1	ENSMMUP00000015004	ENSMMUP00000078670	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Uncharacterized protein.	0.638
AR	SRC	ENSMMUP00000015004	ENSMMUP00000026506	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Tyrosine-protein kinase.	0.815
AR	STAT3	ENSMMUP00000015004	ENSMMUP00000043986	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Signal transducer and activator of transcription.	0.641
ARG2	STAT3	ENSMMUP00000077119	ENSMMUP00000043986	Arginase.	Signal transducer and activator of transcription.	0.455
BMI1	EZH2	ENSMMUP00000001173	ENSMMUP00000060546	RING-type domain-containing protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.947
BMI1	HDAC1	ENSMMUP00000001173	ENSMMUP00000013015	RING-type domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.409
BMI1	HDAC2	ENSMMUP00000001173	ENSMMUP00000057724	RING-type domain-containing protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.635
BMI1	MAPKAPK2	ENSMMUP00000001173	ENSMMUP00000031020	RING-type domain-containing protein.	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily.	0.421
BMI1	PTEN	ENSMMUP00000001173	ENSMMUP00000011055	RING-type domain-containing protein.	Uncharacterized protein.	0.505
BMI1	YY1	ENSMMUP00000001173	ENSMMUP00000032579	RING-type domain-containing protein.	Transcriptional repressor protein YY1.	0.726