STRINGSTRING
IL9 IL9 MYD88 MYD88 IRAK4 IRAK4 IL1B IL1B TLR1 TLR1 IL18 IL18 CYCS CYCS PYCARD PYCARD TRADD TRADD TIRAP TIRAP CASP3 CASP3 BCL2 BCL2 CTSB CTSB CASP1 CASP1 IRF9 IRF9 IFNG IFNG IRAK2 IRAK2 AIM2 AIM2 NPC1 NPC1 FADD FADD CASP7 CASP7 MEX3C MEX3C STAT1 STAT1 TNF TNF TRIM4 TRIM4 NLRP1 NLRP1 IL6 IL6 TLR4 TLR4 CTSL CTSL CASP8 CASP8 GSDMD GSDMD IL10 IL10 IRF3 IRF3 CD209 CD209 APAF1 APAF1 TLR3 TLR3 NLRC4 NLRC4 IL2 IL2 IRAK1 IRAK1 JAK1 JAK1 TRAF6 TRAF6 CASP9 CASP9 MEFV MEFV MAVS MAVS TLR2 TLR2 RIPK1 RIPK1 MLKL MLKL TBK1 TBK1 IRF7 IRF7 IFNAR1 IFNAR1 IL13 IL13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL9Interleukin 9. (144 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
TLR1Toll-like receptor. (786 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (195 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
CTSBPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (453 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (462 aa)
IRF9Interferon regulatory factor 9. (455 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (666 aa)
AIM2Absent in melanoma 2. (343 aa)
NPC1NPC intracellular cholesterol transporter 1. (1297 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (519 aa)
MEX3CMex-3 RNA binding family member C. (705 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
TRIM4Tripartite motif containing 4. (474 aa)
NLRP1Uncharacterized protein. (1537 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
GSDMDGasdermin D. (529 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IRF3Interferon regulatory factor 3. (450 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (444 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1206 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (725 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
CASP9Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa)
MEFVMEFV innate immuity regulator, pyrin. (786 aa)
MAVSMitochondrial antiviral-signaling protein isoform 1. (541 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
MLKLMixed lineage kinase domain like pseudokinase. (470 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
IRF7Interferon regulatory factor 7. (504 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (597 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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