STRINGSTRING
SCN8A SCN8A TH TH CALB1 CALB1 FOXP2 FOXP2 TAF4 TAF4 MRGPRD MRGPRD NTRK1 NTRK1 TAFA1 TAFA1 SLC17A7 SLC17A7 RARRES1 RARRES1 RET RET CNTNAP2 CNTNAP2 SCN5A SCN5A SCN10A SCN10A SCN7A SCN7A CDH8 CDH8 CDH9 CDH9 ATP2B2 ATP2B2 SCN11A SCN11A LDHD LDHD IL10 IL10 TRPC3 TRPC3 TRPV1 TRPV1 KCNJ6 KCNJ6 PLXNC1 PLXNC1 OPRM1 OPRM1 GRIK2 GRIK2 IL31RA IL31RA NTRK3 NTRK3 PLP1 PLP1 TRPM8 TRPM8 TRPA1 TRPA1 GFRA2 GFRA2 SCN1A SCN1A UCHL1 UCHL1 P2RX3 P2RX3 GFRA1 GFRA1 SNAP25 SNAP25 VSNL1 VSNL1 SPARC SPARC NEFH NEFH ADCYAP1 ADCYAP1 PIEZO2 PIEZO2 MPZ MPZ NTRK2 NTRK2 LPAR3 LPAR3 S100B S100B TAFA4 TAFA4 NPPB NPPB NECAB2 NECAB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
THTyrosine hydroxylase. (501 aa)
CALB1Calbindin 1. (261 aa)
FOXP2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (739 aa)
TAF4TATA-box binding protein associated factor 4. (1083 aa)
MRGPRDMAS related GPR family member D; Belongs to the G-protein coupled receptor 1 family. (320 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
TAFA1TAFA chemokine like family member 1. (133 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
RARRES1Retinoic acid receptor responder 1. (293 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1977 aa)
CDH8Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (743 aa)
CDH9Cadherin 9; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1790 aa)
LDHDPutative D-lactate dehydrogenase, mitochondrial isoform 2. (484 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (839 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
PLXNC1Sema domain-containing protein. (1584 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (400 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
IL31RAInterleukin 31 receptor A. (765 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
PLP1Uncharacterized protein. (281 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1144 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (343 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (468 aa)
GFRA1GDNF family receptor alpha 1. (508 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. (206 aa)
VSNL1Visinin like 1. (263 aa)
SPARCKazal-like domain-containing protein. (343 aa)
NEFHNeurofilament heavy; Belongs to the intermediate filament family. (1017 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (198 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2753 aa)
MPZIg-like domain-containing protein. (248 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
TAFA4TAFA chemokine like family member 4. (140 aa)
NPPBNatriuretic peptide B. (160 aa)
NECAB2N-terminal EF-hand calcium binding protein 2. (389 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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