(85 nodes) (2023) Sirtuin 6-A Key Regulator of Hepatic Lipid Metabolism and Liver Health. network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC114669830	Histone H3; Belongs to the histone H3 family. (136 aa)
	CCL2	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (185 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	LOC695427-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	CLOCK	Clock circadian regulator. (852 aa)
	MPO	Myeloperoxidase. (745 aa)
	FZD4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (747 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
	XBP1	X-box binding protein 1. (376 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] (348 aa)
	ICAM1	Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (543 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2332 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	ANXA2	Annexin. (357 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	FASN	Fatty acid synthase. (2576 aa)
	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1 isoform b. (372 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1323 aa)
	NCOA2	Nuclear receptor coactivator. (1468 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (467 aa)
	LOC699443	Histone H3; Belongs to the histone H3 family. (136 aa)
	WWTR1	WW domain containing transcription regulator 1. (432 aa)
	CSE1L	Importin N-terminal domain-containing protein. (1000 aa)
	SIRT6	NAD-dependent deacetylase sirtuin-6. (355 aa)
	TRIM28	Tripartite motif containing 28. (834 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	FOXO3	Forkhead box O3. (672 aa)
	SIRT1	Sirtuin 1. (743 aa)
	LMNA	Prelamin-A/C isoform 1; Belongs to the intermediate filament family. (663 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (486 aa)
	HNRNPA1-2	Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins (By similarity). (320 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	STAT3	Signal transducer and activator of transcription. (871 aa)
	LCK	Tyrosine-protein kinase. (567 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	GCLC	Glutamate--cysteine ligase catalytic subunit isoform a. (637 aa)
	CIDEC	Cell death inducing DFFA like effector c. (255 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (991 aa)
	AFP	Alpha fetoprotein. (609 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
	VGLL4	Uncharacterized protein. (559 aa)
	GCK	Phosphotransferase. (466 aa)
	LOC710748	Histone H3; Belongs to the histone H3 family. (136 aa)
	MTF1	Metal regulatory transcription factor 1. (753 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1155 aa)
	TEAD1	TEA domain transcription factor 1. (641 aa)
	LOC710798	Pyruvate kinase; Belongs to the pyruvate kinase family. (501 aa)
	HNF1A	HNF1 homeobox A. (657 aa)
	ENSMMUP00000054031	Pyruvate kinase; Belongs to the pyruvate kinase family. (398 aa)
	BECN1	Beclin 1. (507 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
	HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
	SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1244 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (818 aa)
	ELOVL6	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
	SCD	Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (442 aa)
	SIRT7	Sirtuin 7. (421 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
	USP48	Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1061 aa)
	SMAD7	Mothers against decapentaplegic homolog. (462 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	NRF1	Nuclear respiratory factor 1. (582 aa)
	LOC693939	Histone H3; Belongs to the histone H3 family. (136 aa)
	ENSMMUP00000068277	Histone H3; Belongs to the histone H3 family. (136 aa)
	KDM2A	Lysine-specific demethylase 2A isoform a. (1162 aa)
	LOC718280	Histone domain-containing protein. (136 aa)
	RRAS2	Ras-related protein R-Ras2 isoform a. (204 aa)
	ATF4	BZIP domain-containing protein. (351 aa)
	BCL2	BCL2 apoptosis regulator. (241 aa)
	CCR2	C-C chemokine receptor type 2; Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity) Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similari [...] (360 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (683 aa)
	IGF2	Insulin like growth factor 2. (244 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2 isoform 1. (606 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	CROT	Carnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (579 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ACACA	ENSMMUP00000018185	ENSMMUP00000012251	ATP binding cassette subfamily B member 11.	Acetyl-CoA carboxylase alpha.	0.510
ABCB11	CROT	ENSMMUP00000018185	ENSMMUP00000079663	ATP binding cassette subfamily B member 11.	Carnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family.	0.686
ABCB11	HADHB	ENSMMUP00000018185	ENSMMUP00000059535	ATP binding cassette subfamily B member 11.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.516
ABCB11	NR1H4	ENSMMUP00000018185	ENSMMUP00000038826	ATP binding cassette subfamily B member 11.	Nuclear receptor subfamily 1 group H member 4.	0.687
ACACA	ABCB11	ENSMMUP00000012251	ENSMMUP00000018185	Acetyl-CoA carboxylase alpha.	ATP binding cassette subfamily B member 11.	0.510
ACACA	ACLY	ENSMMUP00000012251	ENSMMUP00000052047	Acetyl-CoA carboxylase alpha.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.972
ACACA	CROT	ENSMMUP00000012251	ENSMMUP00000079663	Acetyl-CoA carboxylase alpha.	Carnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family.	0.592
ACACA	ELOVL6	ENSMMUP00000012251	ENSMMUP00000061174	Acetyl-CoA carboxylase alpha.	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...]	0.750
ACACA	FASN	ENSMMUP00000012251	ENSMMUP00000016836	Acetyl-CoA carboxylase alpha.	Fatty acid synthase.	0.994
ACACA	HADHB	ENSMMUP00000012251	ENSMMUP00000059535	Acetyl-CoA carboxylase alpha.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.759
ACACA	PKLR	ENSMMUP00000012251	ENSMMUP00000080590	Acetyl-CoA carboxylase alpha.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.554
ACACA	PPARA	ENSMMUP00000012251	ENSMMUP00000021366	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator activated receptor alpha.	0.533
ACACA	SCD	ENSMMUP00000012251	ENSMMUP00000061269	Acetyl-CoA carboxylase alpha.	Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family.	0.694
ACACA	SIRT6	ENSMMUP00000012251	ENSMMUP00000026241	Acetyl-CoA carboxylase alpha.	NAD-dependent deacetylase sirtuin-6.	0.517
ACLY	ACACA	ENSMMUP00000052047	ENSMMUP00000012251	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyl-CoA carboxylase alpha.	0.972
ACLY	CROT	ENSMMUP00000052047	ENSMMUP00000079663	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Carnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family.	0.591
ACLY	ELOVL6	ENSMMUP00000052047	ENSMMUP00000061174	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...]	0.707
ACLY	FASN	ENSMMUP00000052047	ENSMMUP00000016836	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fatty acid synthase.	0.994
ACLY	GCK	ENSMMUP00000052047	ENSMMUP00000051138	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Phosphotransferase.	0.430
ACLY	HADHB	ENSMMUP00000052047	ENSMMUP00000059535	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.934