(30 nodes) (2023) Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development. network (Macaca mulatta)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TULP1	Tubby-like protein; Belongs to the TUB family. (542 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (470 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (717 aa)
	RPGR	Retinitis pigmentosa GTPase regulator. (811 aa)
	CD68	CD68 molecule. (354 aa)
	ABCA4	ATP binding cassette subfamily A member 4. (2273 aa)
	SLC7A14	Putative cationic amino acid transporter. (771 aa)
	CD34	CD34 molecule. (385 aa)
	EDN2	Endothelin 2. (206 aa)
	CASP9	Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa)
	CNGB1	Cyclic nucleotide-binding domain-containing protein. (1247 aa)
	NR2E3	Nuclear receptor subfamily 2 group E member 3. (410 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1206 aa)
	GLUL	Glutamine synthetase. (373 aa)
	SLC39A12	Solute carrier family 39 member 12. (741 aa)
	TEKT2	Tektin 2. (430 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
	SNCG	Gamma-synuclein; Belongs to the synuclein family. (296 aa)
	RHO	Rhodopsin. (348 aa)
	PRPH2	Peripherin 2. (346 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	ATF6	Activating transcription factor 6. (821 aa)
	PRPF31	Pre-mRNA processing factor 31. (525 aa)
	RPE65	Retinoid isomerohydrolase RPE65. (533 aa)
	BCL2	BCL2 apoptosis regulator. (241 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	AGBL5	Cytosolic carboxypeptidase-like protein 5 isoform 1. (886 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	CNGB1	ENSMMUP00000018214	ENSMMUP00000024114	ATP binding cassette subfamily A member 4.	Cyclic nucleotide-binding domain-containing protein.	0.521
ABCA4	NR2E3	ENSMMUP00000018214	ENSMMUP00000025333	ATP binding cassette subfamily A member 4.	Nuclear receptor subfamily 2 group E member 3.	0.554
ABCA4	PRPF31	ENSMMUP00000018214	ENSMMUP00000063653	ATP binding cassette subfamily A member 4.	Pre-mRNA processing factor 31.	0.520
ABCA4	PRPH2	ENSMMUP00000018214	ENSMMUP00000077957	ATP binding cassette subfamily A member 4.	Peripherin 2.	0.757
ABCA4	RHO	ENSMMUP00000018214	ENSMMUP00000063008	ATP binding cassette subfamily A member 4.	Rhodopsin.	0.731
ABCA4	RPE65	ENSMMUP00000018214	ENSMMUP00000067237	ATP binding cassette subfamily A member 4.	Retinoid isomerohydrolase RPE65.	0.832
ABCA4	RPGR	ENSMMUP00000018214	ENSMMUP00000017737	ATP binding cassette subfamily A member 4.	Retinitis pigmentosa GTPase regulator.	0.633
ABCA4	TULP1	ENSMMUP00000018214	ENSMMUP00000006708	ATP binding cassette subfamily A member 4.	Tubby-like protein; Belongs to the TUB family.	0.665
APAF1	BCL2	ENSMMUP00000029484	ENSMMUP00000069881	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.930
APAF1	CASP3	ENSMMUP00000029484	ENSMMUP00000070295	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.996
APAF1	CASP9	ENSMMUP00000029484	ENSMMUP00000023884	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSMMUP00000029484	ENSMMUP00000073390	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	MLKL	ENSMMUP00000029484	ENSMMUP00000010982	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Mixed lineage kinase domain like pseudokinase.	0.457
ATF6	BCL2	ENSMMUP00000063502	ENSMMUP00000069881	Activating transcription factor 6.	BCL2 apoptosis regulator.	0.594
ATF6	CASP3	ENSMMUP00000063502	ENSMMUP00000070295	Activating transcription factor 6.	Caspase 3; Belongs to the peptidase C14A family.	0.593
ATF6	CASP9	ENSMMUP00000063502	ENSMMUP00000023884	Activating transcription factor 6.	Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family.	0.456
ATF6	CYCS	ENSMMUP00000063502	ENSMMUP00000073390	Activating transcription factor 6.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.424
ATF6	IL1B	ENSMMUP00000063502	ENSMMUP00000079493	Activating transcription factor 6.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.401
BCL2	APAF1	ENSMMUP00000069881	ENSMMUP00000029484	BCL2 apoptosis regulator.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.930
BCL2	ATF6	ENSMMUP00000069881	ENSMMUP00000063502	BCL2 apoptosis regulator.	Activating transcription factor 6.	0.594