STRINGSTRING
GFAP GFAP KCNJ6 KCNJ6 SLC25A39 SLC25A39 KCND2 KCND2 ATP6V1D ATP6V1D GABRR2 GABRR2 LMO3 LMO3 SCN8A SCN8A GRIN2B GRIN2B KLF10 KLF10 CSRP2 CSRP2 HOPX HOPX PCLO PCLO GRIK5 GRIK5 FIP1L1 FIP1L1 GAD1 GAD1 RTN4RL2 RTN4RL2 CACNB4 CACNB4 GABRA4 GABRA4 THY1 THY1 KCNJ3 KCNJ3 S100A11 S100A11 ALB ALB GABRA2 GABRA2 CACNA1A CACNA1A RYR1 RYR1 SCN2A SCN2A GRID2 GRID2 RYR2 RYR2 ARID5A ARID5A GLRA2 GLRA2 SIRT2 SIRT2 RBM4B RBM4B KLF4 KLF4 PPARG PPARG S100A11-2 S100A11-2 KCNK12 KCNK12 STMN2 STMN2 BCAS1 BCAS1 FOS FOS MICU2 MICU2 CNR1 CNR1 CLU CLU IER3IP1 IER3IP1 KCNA1 KCNA1 NEUROD2 NEUROD2 NFATC4 NFATC4 GRIA1 GRIA1 KLF6 KLF6 GABRB1 GABRB1 RYR3 RYR3 PTPRC PTPRC SCN1A SCN1A AQP4 AQP4 NFATC2 NFATC2 APOE APOE ITPR1 ITPR1 CACNB3 CACNB3 ITPR2 ITPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
SLC25A39Solute carrier family 25 member 39; Belongs to the mitochondrial carrier (TC 2.A.29) family. (444 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
GABRR2Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
LMO3Uncharacterized protein. (187 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
KLF10Transforming growth factor-beta-inducible early growth response protein 1. (480 aa)
CSRP2Cysteine and glycine-rich protein 2. (193 aa)
HOPXHOP homeobox. (109 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5181 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (1388 aa)
FIP1L1Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
GAD1Glutamate decarboxylase 1 isoform GAD67. (594 aa)
RTN4RL2Reticulon-4 receptor-like 2. (420 aa)
CACNB4SH3 domain-containing protein. (520 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (554 aa)
THY1Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (177 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
S100A11Protein S100; Belongs to the S-100 family. (105 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
GABRA2Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (511 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2411 aa)
RYR1Ryanodine receptor 1. (4928 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
RYR2Ryanodine receptor 2. (4967 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
RBM4BRNA binding motif protein 4B. (371 aa)
KLF4Kruppel like factor 4. (544 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
S100A11-2S100 calcium binding protein A11. (105 aa)
KCNK12Potassium two pore domain channel subfamily K member 12; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (430 aa)
STMN2Stathmin; Belongs to the stathmin family. (179 aa)
BCAS1Breast carcinoma amplified sequence 1. (650 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
MICU2Mitochondrial calcium uptake 2. (456 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. In [...] (472 aa)
CLUClusterin; Belongs to the clusterin family. (489 aa)
IER3IP1Immediate early response 3-interacting protein 1. (82 aa)
KCNA1Voltage-gated potassium channel subunit Kv1.1; Belongs to the potassium channel family. (495 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
NFATC4Nuclear factor of activated T cells 4. (961 aa)
GRIA1Uncharacterized protein. (916 aa)
KLF6Krueppel-like factor 6 isoform A. (283 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
RYR3Ryanodine receptor 3. (4870 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
AQP4Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (348 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
CACNB3SH3 domain-containing protein. (498 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (20%) [HD]