34 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKACG	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
	LOC695427-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1174 aa)
	ITGA6	Integrin alpha-6 isoform a; Belongs to the integrin alpha chain family. (1091 aa)
	ELF5	Uncharacterized protein. (265 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa)
	GATA3	GATA binding protein 3. (444 aa)
	ETS2	Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
	TFAP2C	Transcription factor AP-2 gamma. (450 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
	KRT7	Keratin, type II cytoskeletal 7; Belongs to the intermediate filament family. (469 aa)
	POU5F1	POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency; Belongs to the POU transcription factor family. Class-5 subfamily. (360 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	IL33	Interleukin-33 isoform 1. (270 aa)
	GCM1	Glial cells missing transcription factor 1. (436 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	MMP2	72 kDa type IV collagenase isoform a preproprotein. (660 aa)
	ERVFRD-1	Uncharacterized protein. (537 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
	HBEGF	EGF-like domain-containing protein. (214 aa)
	LOC720132	Major histocompatibility complex, class I, AG; Belongs to the MHC class I family. (339 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC698105	Histone H3.1. (136 aa)
	ERVW-1	Endogenous retrovirus group W member 1, envelope. (495 aa)
	LOC703889	Histone H3.1. (136 aa)
	EOMES	Eomesodermin. (703 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
	LOC100430668	Histone H3.1. (136 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	CDX2	Caudal-type homeobox protein 2. (313 aa)
	LOC695427	Histone H3.1. (136 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CDX2	ENSMMUP00000077296	ENSMMUP00000079152	Bone morphogenetic protein 4.	Caudal-type homeobox protein 2.	0.619
BMP4	EGF	ENSMMUP00000077296	ENSMMUP00000013132	Bone morphogenetic protein 4.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.666
BMP4	ELF5	ENSMMUP00000077296	ENSMMUP00000003267	Bone morphogenetic protein 4.	Uncharacterized protein.	0.473
BMP4	EOMES	ENSMMUP00000077296	ENSMMUP00000072238	Bone morphogenetic protein 4.	Eomesodermin.	0.501
BMP4	FGF4	ENSMMUP00000077296	ENSMMUP00000079036	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.691
BMP4	GATA3	ENSMMUP00000077296	ENSMMUP00000009115	Bone morphogenetic protein 4.	GATA binding protein 3.	0.418
BMP4	ITGA6	ENSMMUP00000077296	ENSMMUP00000003172	Bone morphogenetic protein 4.	Integrin alpha-6 isoform a; Belongs to the integrin alpha chain family.	0.427
BMP4	KRT7	ENSMMUP00000077296	ENSMMUP00000018913	Bone morphogenetic protein 4.	Keratin, type II cytoskeletal 7; Belongs to the intermediate filament family.	0.418
BMP4	POU5F1	ENSMMUP00000077296	ENSMMUP00000020597	Bone morphogenetic protein 4.	POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency; Belongs to the POU transcription factor family. Class-5 subfamily.	0.782
BMP4	TFAP2C	ENSMMUP00000077296	ENSMMUP00000012261	Bone morphogenetic protein 4.	Transcription factor AP-2 gamma.	0.619
BMP4	WNT5A	ENSMMUP00000077296	ENSMMUP00000074193	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.510
CDX2	BMP4	ENSMMUP00000079152	ENSMMUP00000077296	Caudal-type homeobox protein 2.	Bone morphogenetic protein 4.	0.619
CDX2	ELF5	ENSMMUP00000079152	ENSMMUP00000003267	Caudal-type homeobox protein 2.	Uncharacterized protein.	0.755
CDX2	EOMES	ENSMMUP00000079152	ENSMMUP00000072238	Caudal-type homeobox protein 2.	Eomesodermin.	0.691
CDX2	FGF4	ENSMMUP00000079152	ENSMMUP00000079036	Caudal-type homeobox protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.787
CDX2	GATA3	ENSMMUP00000079152	ENSMMUP00000009115	Caudal-type homeobox protein 2.	GATA binding protein 3.	0.664
CDX2	GCM1	ENSMMUP00000079152	ENSMMUP00000029076	Caudal-type homeobox protein 2.	Glial cells missing transcription factor 1.	0.643
CDX2	KRT7	ENSMMUP00000079152	ENSMMUP00000018913	Caudal-type homeobox protein 2.	Keratin, type II cytoskeletal 7; Belongs to the intermediate filament family.	0.744
CDX2	POU5F1	ENSMMUP00000079152	ENSMMUP00000020597	Caudal-type homeobox protein 2.	POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency; Belongs to the POU transcription factor family. Class-5 subfamily.	0.816
CDX2	TFAP2C	ENSMMUP00000079152	ENSMMUP00000012261	Caudal-type homeobox protein 2.	Transcription factor AP-2 gamma.	0.633