STRINGSTRING
PRKDC PRKDC MDM2 MDM2 XPA XPA SMARCA4 SMARCA4 CETN2 CETN2 MGMT MGMT FANCI FANCI ATRIP ATRIP WEE1 WEE1 CDK1 CDK1 PMS2 PMS2 CCNB1 CCNB1 BRCA1 BRCA1 MDC1 MDC1 WRN WRN MLH1 MLH1 CDC25A CDC25A CCNE1 CCNE1 FOXM1 FOXM1 MUS81 MUS81 PLK1 PLK1 EME1 EME1 TOPBP1 TOPBP1 MCM2 MCM2 LOC695427-2 LOC695427-2 KRAS KRAS CYP3A4 CYP3A4 PKMYT1 PKMYT1 XRCC1 XRCC1 PLK3 PLK3 TP53 TP53 BRCA2 BRCA2 PARG PARG LOC699443 LOC699443 CDA CDA PARP2 PARP2 ORC2 ORC2 MTOR MTOR BCL2 BCL2 ALKBH3 ALKBH3 LOC718280 LOC718280 ENSMMUP00000068277 ENSMMUP00000068277 LOC693939 LOC693939 USP1 USP1 REV1 REV1 PDCD1 PDCD1 H3-4 H3-4 DNA2 DNA2 PCNA PCNA CYP17A1 CYP17A1 FANCD2 FANCD2 WEE2 WEE2 LOC114669830 LOC114669830 PLK2 PLK2 LOC710748 LOC710748 UNG UNG POLQ POLQ RAD50 RAD50 RB1 RB1 EGFR EGFR MSH3 MSH3 FBXW7 FBXW7 RAD23B RAD23B EXO1 EXO1 CHEK2 CHEK2 MSH2 MSH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
XPAXPA, DNA damage recognition and repair factor. (294 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
CETN2Centrin-2. (172 aa)
MGMTMethylated-DNA--protein-cysteine methyltransferase. (238 aa)
FANCIFA complementation group I. (1328 aa)
ATRIPATR-interacting protein isoform 1. (791 aa)
WEE1Wee1-like protein kinase. (646 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (938 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
MDC1Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be ac [...] (2144 aa)
WRNWRN RecQ like helicase. (1426 aa)
MLH1MutL homolog 1. (756 aa)
CDC25AM-phase inducer phosphatase 1 isoform a. (524 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
FOXM1Forkhead box protein M1 isoform 2. (770 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
TOPBP1Uncharacterized protein. (1527 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
LOC695427-2Histone H3; Belongs to the histone H3 family. (136 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
CYP3A4Uncharacterized protein. (535 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (499 aa)
XRCC1X-ray repair cross complementing 1. (633 aa)
PLK3Serine/threonine-protein kinase PLK. (664 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
BRCA2BRCA2 DNA repair associated. (3377 aa)
PARGPoly(ADP-ribose) glycohydrolase. (976 aa)
LOC699443Histone H3; Belongs to the histone H3 family. (136 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (182 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (286 aa)
LOC718280Histone domain-containing protein. (136 aa)
ENSMMUP00000068277Histone H3; Belongs to the histone H3 family. (136 aa)
LOC693939Histone H3; Belongs to the histone H3 family. (136 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1285 aa)
PDCD1Programmed cell death 1. (288 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
DNA2DNA replication helicase/nuclease 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1316 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (536 aa)
FANCD2Uncharacterized protein. (1471 aa)
WEE2Wee1-like protein kinase. (568 aa)
LOC114669830Histone H3; Belongs to the histone H3 family. (136 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
LOC710748Histone H3; Belongs to the histone H3 family. (136 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
POLQDNA polymerase theta. (2638 aa)
RAD50Zinc-hook domain-containing protein. (1411 aa)
RB1Retinoblastoma-associated protein. (928 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform 1. (707 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
EXO1Exonuclease 1. (846 aa)
CHEK2Checkpoint kinase 2. (539 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (34%) [HD]