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PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) | ||||
XPA | XPA, DNA damage recognition and repair factor. (294 aa) | ||||
SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) | ||||
CETN2 | Centrin-2. (172 aa) | ||||
MGMT | Methylated-DNA--protein-cysteine methyltransferase. (238 aa) | ||||
FANCI | FA complementation group I. (1328 aa) | ||||
ATRIP | ATR-interacting protein isoform 1. (791 aa) | ||||
WEE1 | Wee1-like protein kinase. (646 aa) | ||||
CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) | ||||
PMS2 | PMS1 homolog 2, mismatch repair system component. (938 aa) | ||||
CCNB1 | G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa) | ||||
MDC1 | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be ac [...] (2144 aa) | ||||
WRN | WRN RecQ like helicase. (1426 aa) | ||||
MLH1 | MutL homolog 1. (756 aa) | ||||
CDC25A | M-phase inducer phosphatase 1 isoform a. (524 aa) | ||||
CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) | ||||
FOXM1 | Forkhead box protein M1 isoform 2. (770 aa) | ||||
MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) | ||||
PLK1 | Serine/threonine-protein kinase PLK. (603 aa) | ||||
EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) | ||||
TOPBP1 | Uncharacterized protein. (1527 aa) | ||||
MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) | ||||
LOC695427-2 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
KRAS | KRAS proto-oncogene, GTPase. (412 aa) | ||||
CYP3A4 | Uncharacterized protein. (535 aa) | ||||
PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (499 aa) | ||||
XRCC1 | X-ray repair cross complementing 1. (633 aa) | ||||
PLK3 | Serine/threonine-protein kinase PLK. (664 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) | ||||
BRCA2 | BRCA2 DNA repair associated. (3377 aa) | ||||
PARG | Poly(ADP-ribose) glycohydrolase. (976 aa) | ||||
LOC699443 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (182 aa) | ||||
PARP2 | Poly [ADP-ribose] polymerase. (570 aa) | ||||
ORC2 | Origin recognition complex subunit 2. (577 aa) | ||||
MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa) | ||||
BCL2 | BCL2 apoptosis regulator. (241 aa) | ||||
ALKBH3 | AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (286 aa) | ||||
LOC718280 | Histone domain-containing protein. (136 aa) | ||||
ENSMMUP00000068277 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
LOC693939 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa) | ||||
REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1285 aa) | ||||
PDCD1 | Programmed cell death 1. (288 aa) | ||||
H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1316 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (536 aa) | ||||
FANCD2 | Uncharacterized protein. (1471 aa) | ||||
WEE2 | Wee1-like protein kinase. (568 aa) | ||||
LOC114669830 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
PLK2 | Serine/threonine-protein kinase PLK. (685 aa) | ||||
LOC710748 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) | ||||
POLQ | DNA polymerase theta. (2638 aa) | ||||
RAD50 | Zinc-hook domain-containing protein. (1411 aa) | ||||
RB1 | Retinoblastoma-associated protein. (928 aa) | ||||
EGFR | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa) | ||||
MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa) | ||||
FBXW7 | F-box/WD repeat-containing protein 7 isoform 1. (707 aa) | ||||
RAD23B | RAD23 homolog B, nucleotide excision repair protein. (409 aa) | ||||
EXO1 | Exonuclease 1. (846 aa) | ||||
CHEK2 | Checkpoint kinase 2. (539 aa) | ||||
MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa) |