(48 nodes) Retinol metabolism network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC709234	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	CYP3A4	Uncharacterized protein. (535 aa)
	DHRS3	Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	AOX2	Uncharacterized protein. (1354 aa)
	CYP2A24	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	ALDH1A3	Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	DHRS4L1	Uncharacterized protein. (146 aa)
	DHRS4	Uncharacterized protein. (278 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (398 aa)
	RDH8	Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
	LOC702239	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	ADH6	PKS_ER domain-containing protein. (374 aa)
	LOC709132	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	CYP2B6	Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. (491 aa)
	LOC721404	Uncharacterized protein; Belongs to the cytochrome P450 family. (525 aa)
	ALDH1A2	Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa)
	LOC709461	Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
	UGT1A1	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (570 aa)
	CYP1A1	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (512 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (504 aa)
	SDR16C5	Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	ADH1A	Alcohol dehydrogenase 1A. (374 aa)
	CYP2C76	Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
	CYP26C1	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
	LOC704750	Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
	DHRS9	Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (378 aa)
	ADH5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (401 aa)
	LOC114675607	Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	AOX1	Aldehyde oxidase 1. (1338 aa)
	UGT2A3	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	BCO1	Beta,beta-carotene 15,15'-monooxygenase. (547 aa)
	UGT2B7	UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid. (529 aa)
	ADH7	Alcohol dehydrogenase 1B (class I), beta polypeptide. (375 aa)
	RETSAT	Retinol saturase. (623 aa)
	PNPLA4	PNPLA domain-containing protein. (277 aa)
	ALDH1A1	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (527 aa)
	RDH5	Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	RPE65	Retinoid isomerohydrolase RPE65. (533 aa)
	AWAT2	Acyl-CoA wax alcohol acyltransferase 2. (333 aa)
	LRAT	LRAT domain-containing protein. (230 aa)
	HSD17B6	17-beta-hydroxysteroid dehydrogenase type 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
	RDH11	Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	DGAT1	O-acyltransferase. (491 aa)
	RDH12	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	RDH16	Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	CYP26A1	Uncharacterized protein; Belongs to the cytochrome P450 family. (555 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH1A	ALDH1A1	ENSMMUP00000034969	ENSMMUP00000065380	Alcohol dehydrogenase 1A.	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	0.965
ADH1A	ALDH1A2	ENSMMUP00000034969	ENSMMUP00000025625	Alcohol dehydrogenase 1A.	Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family.	0.953
ADH1A	ALDH1A3	ENSMMUP00000034969	ENSMMUP00000008758	Alcohol dehydrogenase 1A.	Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family.	0.962
ADH1A	AOX1	ENSMMUP00000034969	ENSMMUP00000051769	Alcohol dehydrogenase 1A.	Aldehyde oxidase 1.	0.932
ADH1A	AOX2	ENSMMUP00000034969	ENSMMUP00000007691	Alcohol dehydrogenase 1A.	Uncharacterized protein.	0.906
ADH1A	AWAT2	ENSMMUP00000034969	ENSMMUP00000068490	Alcohol dehydrogenase 1A.	Acyl-CoA wax alcohol acyltransferase 2.	0.902
ADH1A	BCO1	ENSMMUP00000034969	ENSMMUP00000060321	Alcohol dehydrogenase 1A.	Beta,beta-carotene 15,15'-monooxygenase.	0.906
ADH1A	CYP26A1	ENSMMUP00000034969	ENSMMUP00000078533	Alcohol dehydrogenase 1A.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.909
ADH1A	CYP27C1	ENSMMUP00000034969	ENSMMUP00000072920	Alcohol dehydrogenase 1A.	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.905
ADH1A	CYP2S1	ENSMMUP00000034969	ENSMMUP00000031593	Alcohol dehydrogenase 1A.	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.	0.431
ADH1A	DGAT1	ENSMMUP00000034969	ENSMMUP00000075335	Alcohol dehydrogenase 1A.	O-acyltransferase.	0.904
ADH1A	DHRS3	ENSMMUP00000034969	ENSMMUP00000007504	Alcohol dehydrogenase 1A.	Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.551
ADH1A	LOC702239	ENSMMUP00000034969	ENSMMUP00000020386	Alcohol dehydrogenase 1A.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.431
ADH1A	LOC709132	ENSMMUP00000034969	ENSMMUP00000021653	Alcohol dehydrogenase 1A.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.662
ADH1A	LOC709234	ENSMMUP00000034969	ENSMMUP00000000456	Alcohol dehydrogenase 1A.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.662
ADH1A	LRAT	ENSMMUP00000034969	ENSMMUP00000069062	Alcohol dehydrogenase 1A.	LRAT domain-containing protein.	0.905
ADH1A	PNPLA4	ENSMMUP00000034969	ENSMMUP00000063522	Alcohol dehydrogenase 1A.	PNPLA domain-containing protein.	0.901
ADH1A	RDH11	ENSMMUP00000034969	ENSMMUP00000074874	Alcohol dehydrogenase 1A.	Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.517
ADH1A	RETSAT	ENSMMUP00000034969	ENSMMUP00000062568	Alcohol dehydrogenase 1A.	Retinol saturase.	0.936
ADH1A	UGT1A1	ENSMMUP00000034969	ENSMMUP00000027940	Alcohol dehydrogenase 1A.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.662