STRINGSTRING
RPA3 RPA3 POLN POLN FAAP100 FAAP100 BRCA2 BRCA2 SLX1A SLX1A SLX4 SLX4 ATR ATR POLH POLH BRIP1 BRIP1 RAD51C RAD51C ATRIP ATRIP FANCI FANCI TOP3A TOP3A UBE2T UBE2T ERCC4 ERCC4 FANCE FANCE FANCM FANCM EME1 EME1 FANCB FANCB FAAP24 FAAP24 RPA2 RPA2 MUS81 MUS81 BLM BLM FANCF FANCF REV3L REV3L MLH1 MLH1 LOC107000378 LOC107000378 BRCA1 BRCA1 POLK POLK PMS2 PMS2 POLI POLI RPA1 RPA1 WDR48 WDR48 FANCA FANCA ERCC1 ERCC1 FANCL FANCL FANCD2 FANCD2 PALB2 PALB2 EME2 EME2 FANCC FANCC REV1 REV1 TOP3B TOP3B RMI1 RMI1 USP1 USP1 RMI2 RMI2 TELO2 TELO2 HES1 HES1 FAN1 FAN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A 14 kDa subunit. (121 aa)
POLNDNA polymerase nu. (900 aa)
FAAP100Fanconi anemia-associated protein of 100 kDa isoform b. (881 aa)
BRCA2BRCA2 DNA repair associated. (3377 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (437 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1668 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
POLHDNA polymerase eta. (712 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1189 aa)
RAD51CRAD51 paralog C. (367 aa)
ATRIPATR-interacting protein isoform 1. (791 aa)
FANCIFA complementation group I. (1328 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
FANCEFA complementation group E. (536 aa)
FANCMFA complementation group M. (2050 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
FANCBFA complementation group B. (858 aa)
FAAP24Fanconi anemia-associated protein of 24 kDa. (215 aa)
RPA2Uncharacterized protein. (270 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
BLMBLM RecQ like helicase. (1416 aa)
FANCFFanconi anemia group F protein. (374 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3145 aa)
MLH1MutL homolog 1. (756 aa)
LOC107000378Somatostatin domain-containing protein. (164 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
POLKDNA polymerase kappa. (868 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (938 aa)
POLIDNA polymerase iota. (737 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
WDR48WD repeat domain 48. (745 aa)
FANCAFA complementation group A. (1462 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (442 aa)
FANCLFA complementation group L. (531 aa)
FANCD2Uncharacterized protein. (1471 aa)
PALB2PALB2_WD40 domain-containing protein. (1205 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1285 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
RMI1RecQ-mediated genome instability protein 1. (625 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
RMI2Uncharacterized protein. (147 aa)
TELO2Telomere maintenance 2. (936 aa)
HES1Transcription factor HES-1. (280 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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