79 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)
	AREG	Amphiregulin. (252 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (668 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	RPS6KB2	Non-specific serine/threonine protein kinase. (512 aa)
	SHC1	SHC-transforming protein 1 isoform 3. (584 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
	NRG2	Neuregulin 2. (851 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	PAK4	Non-specific serine/threonine protein kinase. (597 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	NRG3	Neuregulin 3. (696 aa)
	PAK1	Non-specific serine/threonine protein kinase. (575 aa)
	ELK1	ETS domain-containing protein Elk-1. (428 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (735 aa)
	HRAS	Transforming protein p21. (189 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
	NRG4	Neuregulin 4. (125 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	NCK2	Cytoplasmic protein. (393 aa)
	ABL2	Tyrosine-protein kinase. (1182 aa)
	LOC114672301	ETS domain-containing protein. (488 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (763 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	TGFA	Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (166 aa)
	EGFR	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
	SOS2	Uncharacterized protein. (1332 aa)
	SHC3	Uncharacterized protein. (596 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	ERBB3	Receptor tyrosine-protein kinase erbB-3 isoform 1. (1342 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	SHC4	Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	RAF1	Uncharacterized protein. (668 aa)
	CBL	E3 ubiquitin-protein ligase CBL. (907 aa)
	AKT2	AKT serine/threonine kinase 2. (594 aa)
	PIK3R3	Uncharacterized protein. (507 aa)
	GSK3B	Glycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	HBEGF	EGF-like domain-containing protein. (214 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1437 aa)
	NRG1	Neuregulin 1. (700 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
	BAD	Bcl2 antagonist of cell death. (167 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha. (622 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	CBLB	Cbl proto-oncogene B. (982 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (334 aa)
	BTC	Betacellulin. (191 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	PAK3	Uncharacterized protein. (580 aa)
	EREG	Proepiregulin. (169 aa)
	PAK5	Non-specific serine/threonine protein kinase. (748 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSMMUP00000053665	ENSMMUP00000037795	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.943
ABL1	CBL	ENSMMUP00000053665	ENSMMUP00000059041	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL.	0.978
ABL1	CBLB	ENSMMUP00000053665	ENSMMUP00000071708	Tyrosine-protein kinase.	Cbl proto-oncogene B.	0.526
ABL1	CDKN1A	ENSMMUP00000053665	ENSMMUP00000077663	Tyrosine-protein kinase.	Cyclin-dependent kinase inhibitor 1.	0.574
ABL1	CDKN1B	ENSMMUP00000053665	ENSMMUP00000065552	Tyrosine-protein kinase.	Cyclin-dependent kinase inhibitor 1B.	0.496
ABL1	CRK	ENSMMUP00000053665	ENSMMUP00000042452	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.992
ABL1	EGFR	ENSMMUP00000053665	ENSMMUP00000046120	Tyrosine-protein kinase.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.597
ABL1	GRB2	ENSMMUP00000053665	ENSMMUP00000045339	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.984
ABL1	HRAS	ENSMMUP00000053665	ENSMMUP00000028522	Tyrosine-protein kinase.	Transforming protein p21.	0.485
ABL1	KRAS	ENSMMUP00000053665	ENSMMUP00000002635	Tyrosine-protein kinase.	KRAS proto-oncogene, GTPase.	0.464
ABL1	MAPK1	ENSMMUP00000053665	ENSMMUP00000016444	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.544
ABL1	MAPK3	ENSMMUP00000053665	ENSMMUP00000053373	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.471
ABL1	NCK1	ENSMMUP00000053665	ENSMMUP00000064713	Tyrosine-protein kinase.	Cytoplasmic protein.	0.560
ABL1	NCK2	ENSMMUP00000053665	ENSMMUP00000036193	Tyrosine-protein kinase.	Cytoplasmic protein.	0.403
ABL1	PIK3CA	ENSMMUP00000053665	ENSMMUP00000006866	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.500
ABL1	PIK3R1	ENSMMUP00000053665	ENSMMUP00000015140	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.546
ABL1	SHC1	ENSMMUP00000053665	ENSMMUP00000008658	Tyrosine-protein kinase.	SHC-transforming protein 1 isoform 3.	0.957
ABL1	SHC3	ENSMMUP00000053665	ENSMMUP00000049326	Tyrosine-protein kinase.	Uncharacterized protein.	0.937
ABL1	SHC4	ENSMMUP00000053665	ENSMMUP00000054675	Tyrosine-protein kinase.	Src-like proteiny 2 domain-containing-transforming protein C4.	0.923
ABL1	STAT5A	ENSMMUP00000053665	ENSMMUP00000050038	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.944