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KCNU1 KCNU1 ATP1B4 ATP1B4 PDE3B PDE3B ADRB2 ADRB2 GNA11 GNA11 PLCB1 PLCB1 KCNMB3 KCNMB3 PIK3R5 PIK3R5 GNAI3 GNAI3 PDE5A PDE5A NPPA NPPA NPR1 NPR1 ATP2A3 ATP2A3 PDE3A PDE3A CACNA1F CACNA1F PRKG1 PRKG1 ATP2B3 ATP2B3 ADRA2B ADRA2B MAPK1 MAPK1 PLCB3 PLCB3 CACNA1C CACNA1C PPP1CC PPP1CC KCNMB2 KCNMB2 PRKCE PRKCE PPP3CC PPP3CC MYLK MYLK KCNMB4 KCNMB4 PPP3CB PPP3CB MRVI1 MRVI1 NPR2 NPR2 GNA13 GNA13 MYL9 MYL9 MEF2D MEF2D CREB3L2 CREB3L2 MAP2K1 MAP2K1 PPP1CA PPP1CA CACNA1S CACNA1S CALML5 CALML5 ATP1A2 ATP1A2 CNGB1 CNGB1 KCNMA1 KCNMA1 CREB3L1 CREB3L1 GATA4 GATA4 PPP1R12A PPP1R12A PRKG2 PRKG2 ATP2B2 ATP2B2 CREB3L3 CREB3L3 AKT3 AKT3 GNAI2 GNAI2 NOS3 NOS3 PPP1CB PPP1CB ADCY4 ADCY4 ATP1B1 ATP1B1 IRS2 IRS2 NFATC3 NFATC3 ATP2B1 ATP2B1 GNAI1 GNAI1 ADRB3 ADRB3 SRF SRF EDNRA EDNRA PIK3R6 PIK3R6 ROCK2 ROCK2 INS INS CREB1 CREB1 CREB3L4 CREB3L4 ITPR2 ITPR2 ADRA2C ADRA2C CREB5 CREB5 VDAC3 VDAC3 MEF2C MEF2C ADORA1 ADORA1 ITPR3 ITPR3 ATP2A2 ATP2A2 ADRA2A ADRA2A ADCY8 ADCY8 IRS1 IRS1 CALML6 CALML6 RHOA RHOA MYH7 MYH7 ITPR1 ITPR1 ROCK1 ROCK1 ADRB1 ADRB1 ATF2 ATF2 MEF2B MEF2B NFATC2 NFATC2 ADCY3 ADCY3 TRPC6 TRPC6 CACNA1D CACNA1D CNGA1 CNGA1 GNA12 GNA12 ATP1A3 ATP1A3 BDKRB2 BDKRB2 EDNRB EDNRB ATP1A1 ATP1A1 ADCY5 ADCY5 GUCY1B1 GUCY1B1 SLC8A2 SLC8A2 MAPK3 MAPK3 CALML3 CALML3 MEF2A MEF2A ADRA1A ADRA1A ATP1B2 ATP1B2 ATF6B ATF6B AGTR1 AGTR1 RAF1 RAF1 AKT2 AKT2 ADCY2 ADCY2 NFATC4 NFATC4 PPP3R1 PPP3R1 AKT1 AKT1 RGS2 RGS2 GNAQ GNAQ MYLK2 MYLK2 PPIF PPIF PLCB4 PLCB4 SLC25A6 SLC25A6 CREB3 CREB3 ADRA1D ADRA1D ADCY6 ADCY6 MYLK4 MYLK4 PIK3CG PIK3CG SLC25A31 SLC25A31 SLC8A3 SLC8A3 BAD BAD SH2B1 SH2B1 PLCB2 PLCB2 ATP1B3 ATP1B3 ADCY9 ADCY9 ATF4 ATF4 MAP2K2 MAP2K2 ADCY1 ADCY1 GUCY1A2 GUCY1A2 KCNMB1 KCNMB1 NPPC NPPC ADCY7 ADCY7 GUCY1A1 GUCY1A1 CALM2 CALM2 VDAC2 VDAC2 CALM3 CALM3 VDAC1 VDAC1 KCNJ8 KCNJ8 ATP2B4 ATP2B4 KNG1 KNG1 NPPB NPPB NFATC1 NFATC1 ADRA1B ADRA1B FXYD6 FXYD6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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KCNU1Potassium calcium-activated channel subfamily U member 1. (1149 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
PDE3BPhosphodiesterase. (1117 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (415 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (283 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (884 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
PDE5APhosphodiesterase. (875 aa)
NPPANatriuretic peptide A. (153 aa)
NPR1Guanylate cyclase. (1061 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1092 aa)
PDE3APhosphodiesterase. (1141 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1970 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
ADRA2BAdrenoceptor alpha 2B. (445 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (268 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
MYLKMyosin light chain kinase. (1914 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (433 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
MRVI1Murine retrovirus integration site 1 homolog. (886 aa)
NPR2Guanylate cyclase. (1047 aa)
GNA13G protein subunit alpha 13. (409 aa)
MYL9Myosin regulatory light polypeptide 9 isoform a. (172 aa)
MEF2DMyocyte-specific enhancer factor 2D. (521 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CALML5Calmodulin-like protein 5. (146 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
CNGB1Cyclic nucleotide-binding domain-containing protein. (1247 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1233 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
GATA4GATA binding protein 4. (443 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
PRKG2cGMP-dependent protein kinase. (781 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (603 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
IRS2Insulin receptor substrate 2. (1394 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
GNAI1G protein subunit alpha i1. (422 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. (418 aa)
SRFSerum response factor. (508 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ADRA2CAdrenoceptor alpha 2C. (458 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
VDAC3Uncharacterized protein. (299 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1011 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
CALML6Calmodulin like 6. (181 aa)
RHOARas homolog family member A. (209 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (478 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MEF2BMADS-box domain-containing protein. (490 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (759 aa)
GNA12G protein subunit alpha 12. (463 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1031 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform 2. (503 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
RAF1Uncharacterized protein. (668 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
NFATC4Nuclear factor of activated T cells 4. (961 aa)
PPP3R1Uncharacterized protein. (171 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
PPIFPeptidylprolyl isomerase F. (309 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (399 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (372 aa)
ADRA1DAdrenoceptor alpha 1D. (570 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
MYLK4Myosin light chain kinase family member 4. (541 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
BADBcl2 antagonist of cell death. (167 aa)
SH2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1087 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ATF4BZIP domain-containing protein. (351 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (733 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
NPPCC-type natriuretic peptide. (126 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-3 isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
VDAC2Voltage dependent anion channel 2. (308 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
KNG1Kininogen 1. (644 aa)
NPPBNatriuretic peptide B. (160 aa)
NFATC1Nuclear factor of activated T cells 1. (943 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (174 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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