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EGLN3 EGLN3 ANGPT4 ANGPT4 ARNT ARNT PFKM PFKM TFRC TFRC IGF1 IGF1 EIF4EBP1 EIF4EBP1 CAMK2B CAMK2B HK3 HK3 PIK3R2 PIK3R2 HKDC1 HKDC1 HK1 HK1 VEGFA VEGFA PIK3CA PIK3CA PLCG2 PLCG2 RPS6KB2 RPS6KB2 TEK TEK HMOX1 HMOX1 ENO4 ENO4 NPPA NPPA GAPDH GAPDH PIK3CB PIK3CB TF TF EGF EGF ANGPT2 ANGPT2 PFKFB3 PFKFB3 MKNK2 MKNK2 PIK3R1 PIK3R1 LOC694593 LOC694593 PGK2 PGK2 ENO3 ENO3 IGF1R IGF1R MAPK1 MAPK1 LOC712274 LOC712274 LOC704249 LOC704249 LDHAL6A LDHAL6A MAP2K1 MAP2K1 ANGPT1 ANGPT1 AKT3 AKT3 NOS3 NOS3 CAMK2G CAMK2G LOC696854 LOC696854 FLT1 FLT1 EIF4E2 EIF4E2 EPO EPO ALDOB ALDOB PRKCG PRKCG ALDOA ALDOA NFKB1 NFKB1 CUL2 CUL2 LDHA LDHA LDHC LDHC INS INS PDK1 PDK1 TLR4 TLR4 PGK1 PGK1 TIMP1 TIMP1 STAT3 STAT3 ELOB ELOB PDHB PDHB EGLN2 EGLN2 EGFR EGFR IL6 IL6 MAPK3 MAPK3 SLC2A1 SLC2A1 RELA RELA HIF1A HIF1A PLCG1 PLCG1 RBX1 RBX1 ALDOC ALDOC AKT2 AKT2 ENO2 ENO2 PIK3R3 PIK3R3 PFKP PFKP AKT1 AKT1 PRKCB PRKCB VHL VHL EDN1 EDN1 ERBB2 ERBB2 IFNG IFNG CDKN1B CDKN1B CREBBP CREBBP SERPINE1 SERPINE1 PIK3CD PIK3CD CAMK2A CAMK2A LDHAL6B LDHAL6B MAP2K2 MAP2K2 BCL2 BCL2 PRKCA PRKCA LOC106992358 LOC106992358 LDHB LDHB IFNGR2 IFNGR2 ENO1 ENO1 IFNGR1 IFNGR1 MTOR MTOR CYBB CYBB HK2 HK2 EP300 EP300 CDKN1A CDKN1A PDHA2 PDHA2 EGLN1 EGLN1 PFKL PFKL NOS2 NOS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGLN3Egl nine homolog 3. (239 aa)
ANGPT4Angiopoietin 4. (503 aa)
ARNTUncharacterized protein. (786 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
TFRCTransferrin receptor protein 1. (760 aa)
IGF1Insulin like growth factor 1. (208 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
HK3Hexokinase 3. (923 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (921 aa)
VEGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (489 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (512 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
HMOX1Heme oxygenase 1. (288 aa)
ENO4Enolase 4. (624 aa)
NPPANatriuretic peptide A. (153 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
ANGPT2Angiopoietin 2. (496 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (562 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2; Belongs to the protein kinase superfamily. (465 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC694593Uncharacterized protein. (434 aa)
PGK2Phosphoglycerate kinase. (377 aa)
ENO3Enolase 3. (446 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LOC71227440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
LOC704249Phosphoglycerate kinase. (417 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ANGPT1Angiopoietin-1 isoform 1. (498 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
LOC696854L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1474 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (193 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
NFKB1Uncharacterized protein. (977 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (343 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
PGK1Phosphoglycerate kinase. (417 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
ELOBTranscription elongation factor B polypeptide 2 isoform a. (118 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (377 aa)
EGLN2Egl nine homolog 2. (405 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (669 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
ENO2Gamma-enolase. (434 aa)
PIK3R3Uncharacterized protein. (507 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (797 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform 1. (213 aa)
EDN1Preproendothelin-1. (211 aa)
ERBB2Receptor protein-tyrosine kinase. (1437 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (407 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
LOC106992358Uncharacterized protein. (187 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (337 aa)
IFNGR2Interferon gamma receptor 2. (336 aa)
ENO1Uncharacterized protein. (434 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
CYBBCytochrome b-245 beta chain. (617 aa)
HK2Hexokinase 2. (917 aa)
EP300Histone acetyltransferase p300. (2414 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (420 aa)
EGLN1Uncharacterized protein. (426 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (1016 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1299 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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