STRINGSTRING
CDKN2B CDKN2B MAPK9 MAPK9 SETD7 SETD7 KRAS KRAS IGF1 IGF1 PRMT1 PRMT1 PIK3R2 PIK3R2 GADD45B GADD45B USP7 USP7 MAPK8 MAPK8 ATM ATM PIK3CA PIK3CA PLK3 PLK3 FASLG FASLG PTEN PTEN MAPK14 MAPK14 PIK3CB PIK3CB TGFBR2 TGFBR2 EGF EGF PRKAA2 PRKAA2 GABARAP GABARAP PDPK1 PDPK1 PIK3R1 PIK3R1 CDKN2D CDKN2D TGFB3 TGFB3 PRKAB2 PRKAB2 IGF1R IGF1R MAPK1 MAPK1 STK4 STK4 G6PC2 G6PC2 MAPK11 MAPK11 MDM2 MDM2 PRKAG1 PRKAG1 MAP2K1 MAP2K1 PLK1 PLK1 RAG2 RAG2 SMAD4 SMAD4 BCL2L11 BCL2L11 NLK NLK PRKAG3 PRKAG3 TNFSF10 TNFSF10 AKT3 AKT3 FOXG1 FOXG1 PCK2 PCK2 HRAS HRAS IRS2 IRS2 STK11 STK11 BNIP3 BNIP3 PCK1 PCK1 IL10 IL10 TGFB1 TGFB1 FBXO32 FBXO32 TTC33 TTC33 IKBKB IKBKB FOXO3 FOXO3 CCNB1 CCNB1 SLC2A4 SLC2A4 SIRT1 SIRT1 FOXO1 FOXO1 INS INS SGK2 SGK2 GADD45A GADD45A FOXO4 FOXO4 FOXO6 FOXO6 SMAD3 SMAD3 CDK2 CDK2 MAPK10 MAPK10 CHUK CHUK STAT3 STAT3 BRAF BRAF IRS1 IRS1 GRB2 GRB2 GADD45G GADD45G RBL2 RBL2 EGFR EGFR IL7R IL7R SOS2 SOS2 PLK4 PLK4 S1PR1 S1PR1 IL6 IL6 G6PC G6PC NRAS NRAS LOC703700 LOC703700 TGFBR1 TGFBR1 GABARAPL1 GABARAPL1 MAPK3 MAPK3 PLK2 PLK2 PRKAG2 PRKAG2 CAT CAT RAF1 RAF1 CCNB3 CCNB3 CCNB2 CCNB2 AKT2 AKT2 SKP2 SKP2 PIK3R3 PIK3R3 LOC702827 LOC702827 AKT1 AKT1 FBXO25 FBXO25 CDKN1B CDKN1B CREBBP CREBBP AGAP2 AGAP2 SOS1 SOS1 PIK3CD PIK3CD G6PC3 G6PC3 MAP2K2 MAP2K2 ATG12 ATG12 CCNG2 CCNG2 HOMER3 HOMER3 GABARAPL2 GABARAPL2 CSNK1E CSNK1E ARAF ARAF RAG1 RAG1 EP300 EP300 HOMER2 HOMER2 CDKN1A CDKN1A SGK1 SGK1 SOD2 SOD2 CCND1 CCND1 PRKAB1 PRKAB1 GRM1 GRM1 BCL6 BCL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN2BCyclin dependent kinase inhibitor 2B. (158 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SETD7Uncharacterized protein. (367 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
IGF1Insulin like growth factor 1. (208 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1102 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLK3Serine/threonine-protein kinase PLK. (664 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
PTENUncharacterized protein. (589 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
RAG2Recombination activating 2. (532 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2L11Uncharacterized protein. (292 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FOXG1Forkhead box G1. (489 aa)
PCK2Uncharacterized protein. (644 aa)
HRASTransforming protein p21. (189 aa)
IRS2Insulin receptor substrate 2. (1394 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FBXO32F-box only protein 32 isoform 1. (355 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
FOXO3Forkhead box O3. (672 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
SIRT1Sirtuin 1. (743 aa)
FOXO1Forkhead box O1. (655 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (427 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
FOXO4Fork head domain transcription factor AFX1. (505 aa)
FOXO6Forkhead box O6. (560 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CDK2Diacylglycerol kinase. (1053 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
GADD45GCytokine-responsive protein CR6. (159 aa)
RBL2RB transcriptional corepressor like 2. (1141 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
IL7RInterleukin 7 receptor. (459 aa)
SOS2Uncharacterized protein. (1332 aa)
PLK4Polo like kinase 4. (970 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC703700Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
GABARAPL1Uncharacterized protein. (146 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (533 aa)
RAF1Uncharacterized protein. (668 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1362 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
SKP2S-phase kinase-associated protein 2 isoform 1. (424 aa)
PIK3R3Uncharacterized protein. (507 aa)
LOC702827Uncharacterized protein. (117 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FBXO25F-box only protein 25 isoform 1. (367 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
AGAP2Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-L. (1192 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (384 aa)
HOMER3WH1 domain-containing protein. (361 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1081 aa)
EP300Histone acetyltransferase p300. (2414 aa)
HOMER2Homer scaffold protein 2. (431 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
GRM1Metabotropic glutamate receptor 1 isoform alpha. (1195 aa)
BCL6Uncharacterized protein. (735 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.