STRINGSTRING
SEL1L2 SEL1L2 TRAM1 TRAM1 MAPK9 MAPK9 DNAJA2 DNAJA2 PRKCSH PRKCSH PREB PREB MOGS MOGS HSPBP1 HSPBP1 SSR4 SSR4 MAPK8 MAPK8 MAN1C1 MAN1C1 HSPA5 HSPA5 EDEM3 EDEM3 UBXN1 UBXN1 SAR1A SAR1A UBXN2A UBXN2A DERL2 DERL2 TUSC3 TUSC3 XBP1 XBP1 SEC24C SEC24C DERL3 DERL3 EIF2AK3 EIF2AK3 MARCHF6 MARCHF6 UBQLN4 UBQLN4 EDEM2 EDEM2 DNAJB12 DNAJB12 SEC61B SEC61B CAPN2 CAPN2 UBE2D3 UBE2D3 TRAF2 TRAF2 TRAM1L1 TRAM1L1 UBXN4 UBXN4 CANX CANX BCAP31 BCAP31 PDIA6 PDIA6 SEC23B SEC23B LMAN1L LMAN1L MAN1A1 MAN1A1 WFS1 WFS1 HSPH1 HSPH1 NGLY1 NGLY1 ERN1 ERN1 NSFL1C NSFL1C DNAJB1 DNAJB1 RPN1 RPN1 SEC61A1 SEC61A1 SYVN1 SYVN1 CISD1 CISD1 AMFR AMFR SEC13 SEC13 MBTPS1 MBTPS1 VCP VCP CRYAA CRYAA PRKN PRKN SVIP SVIP EIF2S1 EIF2S1 SEC62 SEC62 YOD1 YOD1 SEC24B SEC24B UGGT1 UGGT1 HSP90B1 HSP90B1 PDIA3 PDIA3 RNF5 RNF5 HSPA1L HSPA1L SEC24A SEC24A DNAJC1 DNAJC1 STT3A STT3A HYOU1 HYOU1 UBQLN3 UBQLN3 RPN2 RPN2 STT3B STT3B RAD23B RAD23B MAN1B1 MAN1B1 DNAJC10 DNAJC10 SIL1 SIL1 MAPK10 MAPK10 DNAJC3 DNAJC3 GANAB GANAB STUB1 STUB1 HERPUD1 HERPUD1 CALR CALR DBNL DBNL ERO1A ERO1A DAD1 DAD1 UBQLN2 UBQLN2 PDIA4 PDIA4 ERO1B ERO1B SEC24D SEC24D EIF2AK2 EIF2AK2 CASP12 CASP12 UBE2J1 UBE2J1 MAP3K5 MAP3K5 UGGT2 UGGT2 SKP1-2 SKP1-2 PPP1R15A PPP1R15A HSPA8 HSPA8 HSPA4L HSPA4L ATF6B ATF6B EIF2AK1 EIF2AK1 UBXN8 UBXN8 RBX1 RBX1 RAD23A RAD23A ATXN3 ATXN3 DNAJB11 DNAJB11 OS9 OS9 P4HB P4HB EIF2AK4 EIF2AK4 DNAJC5B DNAJC5B SSR3 SSR3 ERLEC1 ERLEC1 BAG1 BAG1 EEF1E1 EEF1E1 ATF6 ATF6 LMAN2 LMAN2 UBE2G1 UBE2G1 LOC114675515 LOC114675515 UBQLN1 UBQLN1 MAN1A2 MAN1A2 CUL1 CUL1 SEC31B SEC31B SEC63 SEC63 ERP29 ERP29 BAK1 BAK1 ATF4 ATF4 BCL2 BCL2 UBE2G2 UBE2G2 DDIT3 DDIT3 HSPA1A HSPA1A UBXN6 UBXN6 SEC61G SEC61G SAR1B SAR1B CAPN1 CAPN1 CRYAB CRYAB SSR2 SSR2 UBE2J2 UBE2J2 SEC23A SEC23A SLC29A1 SLC29A1 FBXO2 FBXO2 EDEM1 EDEM1 LMAN1 LMAN1 DNAJB2 DNAJB2 PLAA PLAA NFE2L2 NFE2L2 DNAJA1 DNAJA1 DNAJC5 DNAJC5 CKAP4 CKAP4 HSP90AA1 HSP90AA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEL1L2SEL1L2 adaptor subunit of ERAD E3 ligase. (687 aa)
TRAM1Translocating chain-associated membrane protein; Belongs to the TRAM family. (374 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DNAJA2DnaJ heat shock protein family (Hsp40) member A2. (412 aa)
PRKCSHProtein kinase C substrate 80K-H. (534 aa)
PREBProlactin regulatory element-binding protein. (419 aa)
MOGSMannosyl-oligosaccharide glucosidase. (837 aa)
HSPBP1HSPA (Hsp70) binding protein 1. (377 aa)
SSR4Signal sequence receptor subunit 4. (173 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAN1C1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (610 aa)
HSPA578 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family. (654 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (948 aa)
UBXN1UBX domain protein 1. (297 aa)
SAR1AGTP-binding protein SAR1a; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
UBXN2AUBX domain protein 2A. (277 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (265 aa)
TUSC3Tumor suppressor candidate 3 isoform a. (348 aa)
XBP1X-box binding protein 1. (376 aa)
SEC24CSEC24 homolog C, COPII coat complex component. (1117 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (235 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
MARCHF6Membrane associated ring-CH-type finger 6. (952 aa)
UBQLN4Ubiquilin-4. (601 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
DNAJB12DnaJ heat shock protein family (Hsp40) member B12. (375 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
CAPN2Calpain-2 catalytic subunit isoform 1; Belongs to the peptidase C2 family. (700 aa)
UBE2D3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
TRAM1L1Translocating chain-associated membrane protein; Belongs to the TRAM family. (369 aa)
UBXN4UBX domain-containing protein 4. (508 aa)
CANXCalnexin. (592 aa)
BCAP31B cell receptor associated protein 31. (313 aa)
PDIA6Uncharacterized protein; Belongs to the protein disulfide isomerase family. (492 aa)
SEC23BProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
LMAN1LLectin, mannose binding 1 like. (508 aa)
MAN1A1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (736 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
HSPH1Uncharacterized protein. (978 aa)
NGLY1N-glycanase 1. (654 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
NSFL1CUncharacterized protein. (372 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (340 aa)
RPN1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (590 aa)
SEC61A1Protein transport protein Sec61 subunit alpha isoform 1. (476 aa)
SYVN1E3 ubiquitin-protein ligase synoviolin isoform b. (617 aa)
CISD1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
AMFRAutocrine motility factor receptor. (643 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1022 aa)
VCPUncharacterized protein; Belongs to the AAA ATPase family. (823 aa)
CRYAAAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. (172 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
SVIPSmall VCP/p97-interacting protein. (77 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
SEC62SEC62 homolog, preprotein translocation factor. (399 aa)
YOD1YOD1 deubiquitinase. (348 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1277 aa)
UGGT1UDP-glucose glycoprotein glucosyltransferase 1. (1556 aa)
HSP90B1Endoplasmin. (804 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
RNF5E3 ubiquitin-protein ligase RNF5. (180 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1093 aa)
DNAJC1DnaJ homolog subfamily C member 1. (556 aa)
STT3ADolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A. (705 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
UBQLN3Ubiquilin 3. (655 aa)
RPN2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (649 aa)
STT3BSTT3 oligosaccharyltransferase complex catalytic subunit B. (825 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa)
DNAJC10Uncharacterized protein. (831 aa)
SIL1SIL1 nucleotide exchange factor. (472 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
DNAJC3Interferon-induced, double-stranded RNA-activated protein kinase inhibitor. (504 aa)
GANABNeutral alpha-glucosidase AB isoform 3; Belongs to the glycosyl hydrolase 31 family. (966 aa)
STUB1STIP1 homology and U-box containing protein 1. (539 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (449 aa)
CALRCalreticulin. (417 aa)
DBNLUncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (536 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (647 aa)
DAD1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa)
UBQLN2Protein linking IAP with cytoskeleton 2. (624 aa)
PDIA4Protein disulfide-isomerase A4. (644 aa)
ERO1BUncharacterized protein. (467 aa)
SEC24DSEC24 homolog D, COPII coat complex component. (1044 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa)
CASP12Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution; Belongs to the peptidase C14A family. (430 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1483 aa)
UGGT2UDP-glucose glycoprotein glucosyltransferase 2. (1568 aa)
SKP1-2Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (718 aa)
HSPA8Heat shock cognate 71 kDa protein isoform 1; Belongs to the heat shock protein 70 family. (646 aa)
HSPA4LHeat shock protein family A (Hsp70) member 4 like. (840 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (631 aa)
UBXN8UBX domain protein 8. (383 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
ATXN3Ataxin-3 reference isoform. (360 aa)
DNAJB11DnaJ homolog subfamily B member 11. (358 aa)
OS9Protein OS-9 isoform 1. (668 aa)
P4HBProtein disulfide-isomerase. (510 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1694 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
SSR3Translocon-associated protein subunit gamma. (185 aa)
ERLEC1Uncharacterized protein. (508 aa)
BAG1BCL2 associated athanogene 1. (353 aa)
EEF1E1Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (431 aa)
ATF6Activating transcription factor 6. (821 aa)
LMAN2Lectin, mannose binding 2. (356 aa)
UBE2G1Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (187 aa)
LOC114675515Uncharacterized protein. (152 aa)
UBQLN1Protein linking IAP with cytoskeleton 1. (589 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (645 aa)
CUL1Cullin 1; Belongs to the cullin family. (809 aa)
SEC31BSEC31 homolog B, COPII coat complex component. (1198 aa)
SEC63Translocation protein SEC63 homolog. (760 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
BAK1Uncharacterized protein. (261 aa)
ATF4BZIP domain-containing protein. (351 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
UBE2G2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (180 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
HSPA1AUncharacterized protein; Belongs to the heat shock protein 70 family. (642 aa)
UBXN6UBX domain-containing protein. (455 aa)
SEC61GProtein transport protein Sec61 subunit gamma. (68 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (253 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (714 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
SSR2Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (186 aa)
UBE2J2Ubiquitin conjugating enzyme E2 J2. (262 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
SLC29A1HATPase_c domain-containing protein. (1077 aa)
FBXO2F-box protein 2. (327 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (657 aa)
LMAN1ER-Golgi intermediate compartment 53 kDa protein. (510 aa)
DNAJB2J domain-containing protein. (332 aa)
PLAAPhospholipase A-2-activating protein. (795 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform 1. (606 aa)
DNAJA1DnaJ homolog subfamily A member 1. (397 aa)
DNAJC5DnaJ homolog subfamily C member 5. (198 aa)
CKAP4Cytoskeleton associated protein 4. (598 aa)
HSP90AA1HATPase_c domain-containing protein. (733 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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