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DNASE2B DNASE2B IDS IDS CLN3 CLN3 LAMP2 LAMP2 LAPTM4A LAPTM4A SGSH SGSH AP1G2 AP1G2 FUCA1 FUCA1 CTSG CTSG ABCB9 ABCB9 CLTCL1 CLTCL1 LOC114677611 LOC114677611 LOC696128 LOC696128 SPAM1 SPAM1 ATP6V0A2 ATP6V0A2 NPC2 NPC2 SMPD1 SMPD1 TPP1 TPP1 CTSW CTSW LAPTM4B LAPTM4B CLTB CLTB AP1S3 AP1S3 LAMP1 LAMP1 CTSH CTSH CLTC CLTC AP1G1 AP1G1 GNPTAB GNPTAB PSAP PSAP CD63 CD63 CTDSP1 CTDSP1 CD68 CD68 AP1S2 AP1S2 AP4E1 AP4E1 CTSZ CTSZ ASAH1 ASAH1 ACP2 ACP2 IGF2R IGF2R AP3D1 AP3D1 ENTPD4 ENTPD4 MAN2B1 MAN2B1 M6PR M6PR LOC719235 LOC719235 GGA2 GGA2 SCARB2 SCARB2 AP1B1 AP1B1 ABCA2 ABCA2 CTSE CTSE NEU1 NEU1 CTSO CTSO CTSC CTSC ATP6V0A1 ATP6V0A1 GM2A GM2A CTSV CTSV TCIRG1 TCIRG1 DNASE2 DNASE2 ATP6V1H ATP6V1H HEXA HEXA AP1M2 AP1M2 AP4M1 AP4M1 GGA1 GGA1 CTSA CTSA CTSL CTSL HYAL3 HYAL3 AP4B1 AP4B1 SLC11A2 SLC11A2 AP1S1 AP1S1 LGMN LGMN MANBA MANBA ATP6V0D1 ATP6V0D1 GLA GLA PPT1 PPT1 GALC GALC GNS GNS SORT1 SORT1 AP3M1 AP3M1 AP3M2 AP3M2 AP3B1 AP3B1 AP4S1 AP4S1 GUSBA GUSBA AP3B2 AP3B2 CLTA CLTA GLB1 GLB1 GGA3 GGA3 HYAL4 HYAL4 NPC1 NPC1 CLN5 CLN5 ATP6AP1 ATP6AP1 HEXB HEXB NAGA NAGA CTSD CTSD PSAPL1 PSAPL1 CTSB CTSB CTNS CTNS GBA GBA ACP5 ACP5 NAGPA NAGPA HGSNAT HGSNAT ATP6V0A4 ATP6V0A4 ARSA ARSA PLA2G15 PLA2G15 CD164 CD164 ARSB ARSB MFSD8 MFSD8 SLC17A5 SLC17A5 LIPA LIPA NAPSA NAPSA FUCA2 FUCA2 AGA AGA GALNS GALNS GAA GAA LAPTM5 LAPTM5 HYAL2 HYAL2 LITAF LITAF ATP6V0D2 ATP6V0D2 IDUA IDUA NAGLU NAGLU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DNASE2BDeoxyribonuclease 2 beta. (361 aa)
IDSIduronate 2-sulfatase isoform a. (550 aa)
CLN3Battenin. (438 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform B. (410 aa)
LAPTM4ALysosomal-associated transmembrane protein 4A. (233 aa)
SGSHN-sulfoglucosamine sulfohydrolase. (502 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
FUCA1Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (570 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
ABCB9Uncharacterized protein. (766 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1680 aa)
LOC114677611V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
LOC696128Hyaluronidase. (481 aa)
SPAM1Hyaluronidase. (512 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
NPC2NPC intracellular cholesterol transporter 2. (151 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (629 aa)
TPP1Tripeptidyl peptidase 1. (572 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (375 aa)
LAPTM4BLysosomal protein transmembrane 4 beta. (226 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
LAMP1Lysosomal associated membrane protein 1. (733 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1256 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (524 aa)
CD63Tetraspanin. (238 aa)
CTDSP1Solute carrier family 11 member 1. (547 aa)
CD68CD68 molecule. (354 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1137 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (411 aa)
ACP2Uncharacterized protein; Belongs to the histidine acid phosphatase family. (423 aa)
IGF2RInsulin like growth factor 2 receptor. (2491 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1215 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (620 aa)
MAN2B1Alpha-mannosidase. (1013 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (309 aa)
LOC719235Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (422 aa)
GGA2Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (616 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (475 aa)
AP1B1AP complex subunit beta. (949 aa)
ABCA2ATP-binding cassette sub-family A member 2 isoform a. (2435 aa)
CTSECathepsin E; Belongs to the peptidase A1 family. (400 aa)
NEU1Neuraminidase 1. (416 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (321 aa)
CTSCDipeptidyl peptidase 1 isoform a preproprotein; Belongs to the peptidase C1 family. (463 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
GM2AGM2 ganglioside activator. (227 aa)
CTSVUncharacterized protein; Belongs to the peptidase C1 family. (355 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (853 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (404 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
HEXABeta-hexosaminidase. (554 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (639 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (494 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (765 aa)
SLC11A2Solute carrier family 11 member 2. (597 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
LGMNLegumain preproprotein. (433 aa)
MANBAMannosidase beta. (919 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (372 aa)
GLAAlpha-galactosidase. (429 aa)
PPT1Uncharacterized protein. (304 aa)
GALCGalactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family. (685 aa)
GNSN-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (552 aa)
SORT1Sortilin. (878 aa)
AP3M1AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1111 aa)
AP4S1Clat_adaptor_s domain-containing protein. (158 aa)
GUSBABeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (651 aa)
AP3B2AP-3 complex subunit beta. (1112 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
GLB1Beta-galactosidase. (739 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (743 aa)
HYAL4Hyaluronidase. (406 aa)
NPC1NPC intracellular cholesterol transporter 1. (1297 aa)
CLN5Uncharacterized protein. (378 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
HEXBBeta-hexosaminidase. (557 aa)
NAGAAlpha-galactosidase. (411 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (583 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
CTSBPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (453 aa)
CTNSCystinosin, lysosomal cystine transporter. (528 aa)
GBAGlucosylceramidase. (533 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (515 aa)
HGSNATHeparan-alpha-glucosaminide N-acetyltransferase. (717 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (836 aa)
ARSAArylsulfatase A. (507 aa)
PLA2G15Group XV phospholipase A2. (412 aa)
CD164Sialomucin core protein 24 isoform 1. (198 aa)
ARSBArylsulfatase B. (534 aa)
MFSD8Major facilitator superfamily domain-containing protein 8. (518 aa)
SLC17A5Solute carrier family 17 member 5. (495 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
NAPSANapsin A aspartic peptidase; Belongs to the peptidase A1 family. (420 aa)
FUCA2Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (465 aa)
AGAAspartylglucosaminidase. (346 aa)
GALNSGalactosamine (N-acetyl)-6-sulfatase. (599 aa)
GAAGlucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (952 aa)
LAPTM5Lysosomal protein transmembrane 5. (317 aa)
HYAL2Hyaluronidase. (473 aa)
LITAFLipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1. (161 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
IDUAIduronidase alpha-L-. (653 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (743 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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