STRINGSTRING
NPRL3 NPRL3 EIF4B EIF4B WNT5B WNT5B RICTOR RICTOR FZD8 FZD8 KRAS KRAS ATP6V1B1 ATP6V1B1 IGF1 IGF1 EIF4EBP1 EIF4EBP1 WNT16 WNT16 TSC2 TSC2 PIK3R2 PIK3R2 FZD4 FZD4 LPIN3 LPIN3 WNT3A WNT3A PIK3CA PIK3CA PRR5 PRR5 ATP6V1E2 ATP6V1E2 TBC1D7 TBC1D7 RPS6KB2 RPS6KB2 DVL3 DVL3 WNT8B WNT8B RPTOR RPTOR FZD10 FZD10 WNT2B WNT2B PTEN PTEN PIK3CB PIK3CB CAB39 CAB39 TSC1 TSC1 PRKAA2 PRKAA2 FZD2 FZD2 PDPK1 PDPK1 PIK3R1 PIK3R1 IGF1R IGF1R MAPK1 MAPK1 LOC712274 LOC712274 CAB39L CAB39L LAMTOR5 LAMTOR5 WNT1 WNT1 MAP2K1 MAP2K1 STRADB STRADB RRAGA RRAGA WNT7A WNT7A MLST8 MLST8 SEC13 SEC13 GRB10 GRB10 SESN2 SESN2 AKT3 AKT3 SLC3A2 SLC3A2 ATP6V1A ATP6V1A WNT3 WNT3 ATP6V1D ATP6V1D HRAS HRAS CLIP1 CLIP1 RPS6KA1 RPS6KA1 EIF4E2 EIF4E2 STK11 STK11 WNT8A WNT8A WDR59 WDR59 RRAGC RRAGC TTC33 TTC33 PRKCG PRKCG FZD6 FZD6 ATP6V1H ATP6V1H IKBKB IKBKB FNIP2 FNIP2 SLC38A9 SLC38A9 ANAPC15 ANAPC15 ATP6V1E1 ATP6V1E1 LRP5 LRP5 INS INS MAPKAP1 MAPKAP1 FZD7 FZD7 ATP6V1C1 ATP6V1C1 ATP6V1G1 ATP6V1G1 CASTOR2 CASTOR2 CHUK CHUK BRAF BRAF IRS1 IRS1 GRB2 GRB2 RHOA RHOA SOS2 SOS2 DVL1 DVL1 FZD9 FZD9 RPS6KA2 RPS6KA2 YWHAH YWHAH MIOS MIOS RPS6KA6 RPS6KA6 ULK2 ULK2 ATP6V1B2 ATP6V1B2 NRAS NRAS TNFRSF1A TNFRSF1A RRAGD RRAGD STRADA STRADA MAPK3 MAPK3 DEPTOR DEPTOR TNF TNF RAF1 RAF1 LAMTOR3 LAMTOR3 WNT10B WNT10B WDR24 WDR24 AKT2 AKT2 SKP2 SKP2 PIK3R3 PIK3R3 GSK3B GSK3B DVL2 DVL2 RNF152 RNF152 AKT1 AKT1 PRKCB PRKCB WNT11 WNT11 WNT2 WNT2 LRP6 LRP6 WNT6 WNT6 NPRL2 NPRL2 DDIT4 DDIT4 RHEB RHEB FZD3 FZD3 SOS1 SOS1 WNT4 WNT4 LPIN2 LPIN2 PIK3CD PIK3CD RRAGB RRAGB WNT10A WNT10A TTI1 TTI1 MAP2K2 MAP2K2 PRKCA PRKCA WNT9B WNT9B LAMTOR2 LAMTOR2 ATP6V1G2 ATP6V1G2 MTOR MTOR WNT5A WNT5A WNT7B WNT7B FLCN FLCN SLC7A5 SLC7A5 WNT9A WNT9A ULK1 ULK1 TELO2 TELO2 AKT1S1 AKT1S1 LPIN1 LPIN1 SGK1 SGK1 FZD5 FZD5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPRL3Nitrogen permease regulator 3-like protein isoform 1. (569 aa)
EIF4BEukaryotic translation initiation factor 4B. (607 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
IGF1Insulin like growth factor 1. (208 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TSC2TSC complex subunit 2. (2057 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
FZD4Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
LPIN3Lipin 3. (852 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRR5Uncharacterized protein. (379 aa)
ATP6V1E2Uncharacterized protein. (226 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (512 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (716 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
PTENUncharacterized protein. (589 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CAB39Calcium-binding protein 39. (341 aa)
TSC1TSC complex subunit 1. (1164 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LOC71227440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
STRADBSTE20-related kinase adapter protein beta isoform 1. (418 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
MLST8MTOR associated protein, LST8 homolog. (479 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
GRB10Uncharacterized protein. (631 aa)
SESN2Sestrin-2. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SLC3A24F2 cell-surface antigen heavy chain isoform c. (630 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (617 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
HRASTransforming protein p21. (189 aa)
CLIP1CAP-Gly domain containing linker protein 1. (2194 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
WDR59WD repeat domain 59. (1001 aa)
RRAGCRas related GTP binding C. (399 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
FNIP2Folliculin interacting protein 2. (1147 aa)
SLC38A9Putative sodium-coupled neutral amino acid transporter 9. (561 aa)
ANAPC15Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (253 aa)
ATP6V1E1V-type proton ATPase subunit E 1 isoform a. (226 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform 1. (522 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
CASTOR2GATS-like protein 2. (329 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
RHOARas homolog family member A. (209 aa)
SOS2Uncharacterized protein. (1332 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
YWHAHDEP domain-containing protein. (1603 aa)
MIOSMeiosis regulator for oocyte development. (877 aa)
RPS6KA6Ribosomal protein S6 kinase. (860 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1025 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (507 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
RRAGDRas-related GTP-binding protein D. (400 aa)
STRADASTE20-related kinase adapter protein alpha isoform 1. (431 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
RAF1Uncharacterized protein. (668 aa)
LAMTOR3Ragulator complex protein LAMTOR3 isoform 1. (124 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WDR24WD repeat domain 24. (790 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
SKP2S-phase kinase-associated protein 2 isoform 1. (424 aa)
PIK3R3Uncharacterized protein. (507 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
DVL2Dishevelled segment polarity protein 2. (767 aa)
RNF152RING finger protein 152. (203 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (411 aa)
DDIT4Uncharacterized protein. (261 aa)
RHEBUncharacterized protein. (249 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LPIN2Lipin 2. (933 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RRAGBRas-related GTP-binding protein B long isoform. (374 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TTI1TELO2 interacting protein 1. (1089 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
LAMTOR2Robl_LC7 domain-containing protein. (135 aa)
ATP6V1G2V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (680 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (507 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
TELO2Telomere maintenance 2. (936 aa)
AKT1S1Uncharacterized protein. (277 aa)
LPIN1Lipin 1. (975 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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