STRINGSTRING
PPP2R3A PPP2R3A PFKM PFKM IGF1 IGF1 EIF4EBP1 EIF4EBP1 TSC2 TSC2 PIK3R2 PIK3R2 LEPR LEPR GYS1 GYS1 CRTC2 CRTC2 PPP2R3B PPP2R3B PIK3CA PIK3CA LEP LEP RPS6KB2 RPS6KB2 HMGCR HMGCR HNF4A HNF4A ELAVL1 ELAVL1 RPTOR RPTOR PPP2R5E PPP2R5E PIK3CB PIK3CB ACACA ACACA CAB39 CAB39 CCNA2 CCNA2 TSC1 TSC1 PRKAA2 PRKAA2 PFKFB3 PFKFB3 PDPK1 PDPK1 PIK3R1 PIK3R1 PRKAB2 PRKAB2 IGF1R IGF1R FASN FASN PPP2R2C PPP2R2C CAB39L CAB39L G6PC2 G6PC2 PRKAG1 PRKAG1 GYS2 GYS2 CREB3L2 CREB3L2 ADIPOR2 ADIPOR2 LIPE LIPE STRADB STRADB CREB3L1 CREB3L1 PRKAG3 PRKAG3 PPP2R3C PPP2R3C CREB3L3 CREB3L3 AKT3 AKT3 PPP2CB PPP2CB PCK2 PCK2 IRS2 IRS2 PPP2R1A PPP2R1A PFKFB1 PFKFB1 STK11 STK11 PPP2R2D PPP2R2D FBP1 FBP1 PCK1 PCK1 TTC33 TTC33 FOXO3 FOXO3 MAP3K7 MAP3K7 SCD5 SCD5 SLC2A4 SLC2A4 SIRT1 SIRT1 FOXO1 FOXO1 INS INS CREB1 CREB1 CREB3L4 CREB3L4 CREB5 CREB5 CCNA1 CCNA1 PPP2R2A PPP2R2A IRS1 IRS1 PPP2R1B PPP2R1B PFKFB4 PFKFB4 G6PC G6PC EEF2 EEF2 RAB10 RAB10 CPT1B CPT1B SREBF1 SREBF1 STRADA STRADA PPP2R5B PPP2R5B ADRA1A ADRA1A ADIPOQ ADIPOQ PRKAG2 PRKAG2 PPP2R5C PPP2R5C PPP2R2B PPP2R2B AKT2 AKT2 PPARGC1A PPARGC1A PIK3R3 PIK3R3 PFKP PFKP PPP2R5D PPP2R5D AKT1 AKT1 CREB3 CREB3 EEF2K EEF2K RHEB RHEB FBP2 FBP2 ADIPOR1 ADIPOR1 PIK3CD PIK3CD G6PC3 G6PC3 CAMKK2 CAMKK2 ACACB ACACB RAB8A RAB8A LOC106992358 LOC106992358 PFKFB2 PFKFB2 PPP2R5A PPP2R5A CFTR CFTR CD36 CD36 MTOR MTOR RAB14 RAB14 ENSMMUP00000075823 ENSMMUP00000075823 PPARG PPARG ULK1 ULK1 AKT1S1 AKT1S1 PFKL PFKL CCND1 CCND1 PRKAB1 PRKAB1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1120 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
IGF1Insulin like growth factor 1. (208 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
TSC2TSC complex subunit 2. (2057 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
GYS1Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family. (737 aa)
CRTC2CREB-regulated transcription coactivator 2. (694 aa)
PPP2R3BEF-hand domain-containing protein. (572 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (512 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (471 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ACACAAcetyl-CoA carboxylase alpha. (2332 aa)
CAB39Calcium-binding protein 39. (341 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (432 aa)
TSC1TSC complex subunit 1. (1164 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (562 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FASNFatty acid synthase. (2576 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (629 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa)
ADIPOR2Adiponectin receptor 2. (406 aa)
LIPELipase E, hormone sensitive type. (1072 aa)
STRADBSTE20-related kinase adapter protein beta isoform 1. (418 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (603 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PCK2Uncharacterized protein. (644 aa)
IRS2Insulin receptor substrate 2. (1394 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (522 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (467 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
FOXO3Forkhead box O3. (672 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (620 aa)
SCD5Stearoyl-CoA desaturase 5 isoform a; Belongs to the fatty acid desaturase type 1 family. (330 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
SIRT1Sirtuin 1. (743 aa)
FOXO1Forkhead box O1. (655 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CCNA1Cyclin-A1 isoform a; Belongs to the cyclin family. (465 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4. (469 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
EEF2Elongation factor 2. (858 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
CPT1BCarnitine palmitoyltransferase 1B. (876 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
STRADASTE20-related kinase adapter protein alpha isoform 1. (431 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (505 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PPARGC1APPARG coactivator 1 alpha. (818 aa)
PIK3R3Uncharacterized protein. (507 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (797 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (372 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
RHEBUncharacterized protein. (249 aa)
FBP2FBPase domain-containing protein; Belongs to the FBPase class 1 family. (345 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (666 aa)
ACACBAcetyl-CoA carboxylase beta. (2486 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
LOC106992358Uncharacterized protein. (187 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2 isoform a. (505 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1489 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
RAB14Ras-related protein Rab-14. (215 aa)
ENSMMUP00000075823Uncharacterized protein. (290 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
AKT1S1Uncharacterized protein. (277 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (1016 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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