STRINGSTRING
KRAS KRAS IGF1 IGF1 PIK3R2 PIK3R2 PIK3CA PIK3CA RPS6KB2 RPS6KB2 RPTOR RPTOR PIK3CB PIK3CB HDAC1 HDAC1 PRKAA2 PRKAA2 FOXA2 FOXA2 PIK3R1 PIK3R1 PRKAB2 PRKAB2 IGF1R IGF1R PRKAG1 PRKAG1 PRKAG3 PRKAG3 AKT3 AKT3 PRKACG PRKACG ADCY4 ADCY4 HRAS HRAS IRS2 IRS2 TTC33 TTC33 FOXO3 FOXO3 HSPA1L HSPA1L SIRT1 SIRT1 FOXO1 FOXO1 CLPB CLPB INS INS ADCY8 ADCY8 IRS1 IRS1 ADCY3 ADCY3 NRAS NRAS ADCY5 ADCY5 PRKACA PRKACA HSPA8 HSPA8 PRKAG2 PRKAG2 CAT CAT HDAC2 HDAC2 AKT2 AKT2 ADCY2 ADCY2 PRKACB PRKACB PIK3R3 PIK3R3 AKT1 AKT1 ADCY6 ADCY6 SOD1 SOD1 PIK3CD PIK3CD EIF4EBP2 EIF4EBP2 ADCY9 ADCY9 ADCY1 ADCY1 HSPA1A HSPA1A MTOR MTOR CRYAB CRYAB ADCY7 ADCY7 AKT1S1 AKT1S1 SOD2 SOD2 PRKAB1 PRKAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (412 aa)
IGF1Insulin like growth factor 1. (208 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (512 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
FOXA2Forkhead box A2. (457 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
HRASTransforming protein p21. (189 aa)
IRS2Insulin receptor substrate 2. (1394 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
FOXO3Forkhead box O3. (672 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
SIRT1Sirtuin 1. (743 aa)
FOXO1Forkhead box O1. (655 aa)
CLPBANK_REP_REGION domain-containing protein. (712 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
HSPA8Heat shock cognate 71 kDa protein isoform 1; Belongs to the heat shock protein 70 family. (646 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (533 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PIK3R3Uncharacterized protein. (507 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (161 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
HSPA1AUncharacterized protein; Belongs to the heat shock protein 70 family. (642 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
AKT1S1Uncharacterized protein. (277 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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