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ATP1B4 ATP1B4 PPP2R3A PPP2R3A RYR2 RYR2 ADRB2 ADRB2 CAMK2B CAMK2B CACNG1 CACNG1 PLCB1 PLCB1 PPP2R3B PPP2R3B PIK3R5 PIK3R5 GNAI3 GNAI3 AGT AGT CACNA2D2 CACNA2D2 ACTC1 ACTC1 CACNB2 CACNB2 KCNQ1 KCNQ1 CACNG7 CACNG7 PPP2R5E PPP2R5E ATP2A3 ATP2A3 MAPK14 MAPK14 CACNA1F CACNA1F LOC694289 LOC694289 CACNB4 CACNB4 TPM3 TPM3 ATP2B3 ATP2B3 MAPK1 MAPK1 PLCB3 PLCB3 CACNA1C CACNA1C PPP2R2C PPP2R2C TNNT2 TNNT2 CACNG3 CACNG3 PPP1CC PPP1CC MAPK11 MAPK11 MYL3 MYL3 SCN5A SCN5A TPM2 TPM2 CREB3L2 CREB3L2 CACNA2D4 CACNA2D4 PPP1CA PPP1CA CACNA1S CACNA1S CALML5 CALML5 ATP1A2 ATP1A2 CREB3L1 CREB3L1 PPP2R3C PPP2R3C ATP2B2 ATP2B2 CREB3L3 CREB3L3 AKT3 AKT3 GNAI2 GNAI2 PRKACG PRKACG PPP1CB PPP1CB ADCY4 ADCY4 PPP2CB PPP2CB ATP1B1 ATP1B1 CAMK2G CAMK2G PPP2R1A PPP2R1A PPP2R2D PPP2R2D ATP2B1 ATP2B1 GNAI1 GNAI1 PIK3R6 PIK3R6 CACNG2 CACNG2 CREB1 CREB1 CREB3L4 CREB3L4 CREB5 CREB5 RPS6KA5 RPS6KA5 ATP2A2 ATP2A2 PPP2R2A PPP2R2A ADCY8 ADCY8 CALML6 CALML6 CACNG8 CACNG8 CACNB3 CACNB3 MYH7 MYH7 ADRB1 ADRB1 ATF2 ATF2 ADCY3 ADCY3 CACNG6 CACNG6 PPP2R1B PPP2R1B CACNA1D CACNA1D ATP1A3 ATP1A3 ATP1A1 ATP1A1 CACNA2D1 CACNA2D1 ADCY5 ADCY5 SLC8A2 SLC8A2 MAPK3 MAPK3 CALML3 CALML3 RAPGEF4 RAPGEF4 PPP2R5B PPP2R5B PRKACA PRKACA ADRA1A ADRA1A ATP1B2 ATP1B2 SLC9A1 SLC9A1 ATF6B ATF6B PPP2R5C PPP2R5C RAPGEF3 RAPGEF3 AGTR1 AGTR1 PPP2R2B PPP2R2B MYL2 MYL2 AKT2 AKT2 ADCY2 ADCY2 PRKACB PRKACB PPP2R5D PPP2R5D AKT1 AKT1 GNAQ GNAQ PLCB4 PLCB4 SCN1B SCN1B CREB3 CREB3 ADRA1D ADRA1D ADCY6 ADCY6 CACNG5 CACNG5 PIK3CG PIK3CG SLC8A3 SLC8A3 SH2B1 SH2B1 PLCB2 PLCB2 ATP1B3 ATP1B3 ADCY9 ADCY9 CAMK2A CAMK2A CACNG4 CACNG4 ATF4 ATF4 ADCY1 ADCY1 BCL2 BCL2 PRKCA PRKCA SCN4B SCN4B PPP2R5A PPP2R5A CACNA2D3 CACNA2D3 ADCY7 ADCY7 ENSMMUP00000075823 ENSMMUP00000075823 CALM2 CALM2 TNNC1 TNNC1 TPM4 TPM4 CALM3 CALM3 AGTR2 AGTR2 ATP2B4 ATP2B4 ADRA1B ADRA1B FXYD6 FXYD6
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1120 aa)
RYR2Ryanodine receptor 2. (4967 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (415 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PPP2R3BEF-hand domain-containing protein. (572 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (884 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
AGTAngiotensinogen preproprotein; Belongs to the serpin family. (485 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1153 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
CACNB2SH3 domain-containing protein. (660 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (471 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1092 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1970 aa)
LOC694289Uncharacterized protein. (394 aa)
CACNB4SH3 domain-containing protein. (520 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (285 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (629 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MYL3Myosin light chain 3. (254 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
TPM2Tropomyosin beta chain isoform 2; Belongs to the tropomyosin family. (284 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1137 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CALML5Calmodulin-like protein 5. (146 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (603 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
GNAI1G protein subunit alpha i1. (422 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1011 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CALML6Calmodulin like 6. (181 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (387 aa)
CACNB3SH3 domain-containing protein. (498 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (478 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1031 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1047 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (505 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
MYL2Myosin light chain 2. (166 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (402 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (372 aa)
ADRA1DAdrenoceptor alpha 1D. (570 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
SH2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1087 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
CACNG4Uncharacterized protein. (657 aa)
ATF4BZIP domain-containing protein. (351 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (316 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1108 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ENSMMUP00000075823Uncharacterized protein. (290 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (213 aa)
TPM4Tropomyosin alpha-4 chain isoform 1; Belongs to the tropomyosin family. (284 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (365 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (174 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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