STRINGSTRING
RBPJL RBPJL NUMBL NUMBL DVL3 DVL3 HDAC1 HDAC1 DTX4 DTX4 ADAM17 ADAM17 NOTCH3 NOTCH3 KAT2A KAT2A MAML2 MAML2 LFNG LFNG NOTCH1 NOTCH1 DTX2 DTX2 JAG1 JAG1 DLL3 DLL3 DLL1 DLL1 MAML3 MAML3 CTBP2 CTBP2 CIR1 CIR1 PSEN1 PSEN1 PTCRA PTCRA NCOR2 NCOR2 NCSTN NCSTN NUMB NUMB DTX3 DTX3 NOTCH2 NOTCH2 DVL1 DVL1 SNW1 SNW1 MFNG MFNG RBPJ RBPJ HEY1 HEY1 HDAC2 HDAC2 MAML1 MAML1 DVL2 DVL2 KAT2B KAT2B RFNG RFNG ATXN1 ATXN1 HEY2 HEY2 DTX3L DTX3L DTX1 DTX1 CREBBP CREBBP DLL4 DLL4 HEYL HEYL ATXN1L ATXN1L APH1A APH1A APH1B APH1B JAG2 JAG2 PSEN2 PSEN2 EP300 EP300 HES1 HES1 CTBP1 CTBP1 PSENEN PSENEN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
NUMBLNUMB like endocytic adaptor protein. (762 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (716 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 preproprotein. (824 aa)
NOTCH3Notch receptor 3. (2321 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
MAML2Mastermind like transcriptional coactivator 2. (1151 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (379 aa)
NOTCH1Notch receptor 1. (2556 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
MAML3Mastermind like transcriptional coactivator 3. (1133 aa)
CTBP2C-terminal binding protein 2. (985 aa)
CIR1Corepressor interacting with RBPJ, 1. (589 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
PTCRAUncharacterized protein. (281 aa)
NCOR2Nuclear receptor corepressor 2. (2516 aa)
NCSTNNicastrin. (720 aa)
NUMBNUMB endocytic adaptor protein. (711 aa)
DTX3Deltex E3 ubiquitin ligase 3. (350 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
SNW1SNW domain-containing protein 1. (536 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (321 aa)
RBPJUncharacterized protein. (500 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
MAML1Mastermind like transcriptional coactivator 1. (1014 aa)
DVL2Dishevelled segment polarity protein 2. (767 aa)
KAT2BLysine acetyltransferase 2B. (866 aa)
RFNGRFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (433 aa)
ATXN1Ataxin 1. (817 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
DTX1Deltex E3 ubiquitin ligase 1. (622 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (477 aa)
ATXN1LAXH domain-containing protein. (691 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (274 aa)
APH1BGamma-secretase subunit APH-1B isoform 1. (257 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1290 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
EP300Histone acetyltransferase p300. (2414 aa)
HES1Transcription factor HES-1. (280 aa)
CTBP1C-terminal-binding protein 1 isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
PSENENGamma-secretase subunit PEN-2. (101 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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