STRINGSTRING
AXIN1 AXIN1 LLGL2 LLGL2 WNT5B WNT5B FZD8 FZD8 AREG AREG WNT16 WNT16 YAP1 YAP1 RASSF6 RASSF6 FZD4 FZD4 BMP7 BMP7 ID1 ID1 WNT3A WNT3A LOC704010 LOC704010 CRB2 CRB2 YWHAZ YWHAZ DVL3 DVL3 WNT8B WNT8B FZD10 FZD10 WWC1 WWC1 LOC718677 LOC718677 WNT2B WNT2B BMPR2 BMPR2 LOC705671 LOC705671 TGFBR2 TGFBR2 NF2 NF2 FZD2 FZD2 TP53BP2 TP53BP2 CDH1 CDH1 BMP5 BMP5 TGFB3 TGFB3 PPP2R2C PPP2R2C PPP1CC PPP1CC PARD6G PARD6G MYC MYC WNT1 WNT1 SNAI2 SNAI2 TP73 TP73 PPP1CA PPP1CA CTNNA1 CTNNA1 FRMD6 FRMD6 SMAD4 SMAD4 SMAD1 SMAD1 WNT7A WNT7A PRKCZ PRKCZ LATS2 LATS2 TCF7L1 TCF7L1 FRMD1 FRMD1 PPP1CB PPP1CB WNT3 WNT3 PPP2CB PPP2CB MPP5 MPP5 BMP6 BMP6 PPP2R1A PPP2R1A PPP2R2D PPP2R2D TCF7L2 TCF7L2 WNT8A WNT8A TGFB1 TGFB1 FZD6 FZD6 CTNNA3 CTNNA3 PARD3 PARD3 CTNNA2 CTNNA2 MOB1A MOB1A DLG2 DLG2 DLG1 DLG1 AMOT AMOT FZD7 FZD7 SMAD3 SMAD3 CCND3 CCND3 ACTG1 ACTG1 PPP2R2A PPP2R2A CCN2 CCN2 SMAD2 SMAD2 STK3 STK3 BIRC5 BIRC5 DVL1 DVL1 FZD9 FZD9 ID2 ID2 BMPR1B BMPR1B AFP AFP YWHAE YWHAE PPP2R1B PPP2R1B BTRC BTRC PATJ PATJ TGFBR1 TGFBR1 SAV1 SAV1 APC2 APC2 PPP2R2B PPP2R2B GLI2 GLI2 AJUBA AJUBA WNT10B WNT10B YWHAQ YWHAQ BMP8B BMP8B GSK3B GSK3B RASSF1 RASSF1 DVL2 DVL2 YWHAB YWHAB WNT11 WNT11 WNT2 WNT2 CTNNB1 CTNNB1 SMAD7 SMAD7 NKD1 NKD1 WNT6 WNT6 GDF6 GDF6 YWHAG YWHAG FZD3 FZD3 BMP2 BMP2 GDF5 GDF5 LIMD1 LIMD1 SERPINE1 SERPINE1 WNT4 WNT4 DLG4 DLG4 PARD6B PARD6B WNT10A WNT10A PRKCI PRKCI WTIP WTIP APC APC WNT9B WNT9B CSNK1D CSNK1D BIRC3 BIRC3 AMH AMH FGF1 FGF1 LATS1 LATS1 CSNK1E CSNK1E ITGB2 ITGB2 WNT5A WNT5A TEAD2 TEAD2 BIRC2 BIRC2 PARD6A PARD6A WNT7B WNT7B AXIN2 AXIN2 WNT9A WNT9A BMP4 BMP4 GDF7 GDF7 DLG5 DLG5 FZD5 FZD5 BMPR1A BMPR1A CCND1 CCND1 LLGL1 LLGL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AXIN1Axin 1. (867 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
AREGAmphiregulin. (252 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
YAP1Yes associated protein 1. (508 aa)
RASSF6Ras association domain family member 6. (369 aa)
FZD4Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ID1DNA-binding protein inhibitor ID-1 isoform a. (154 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC70401014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (716 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
WWC1WW and C2 domain containing 1. (1024 aa)
LOC718677TGF_BETA_2 domain-containing protein. (402 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LOC705671Uncharacterized protein. (398 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NF2Merlin isoform 1. (595 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
TP53BP2Tumor protein p53 binding protein 2. (1134 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (629 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SNAI2Protein snail-like protein 2. (268 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
CTNNA1Uncharacterized protein. (906 aa)
FRMD6FERM domain containing 6. (622 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
LATS2Non-specific serine/threonine protein kinase. (1086 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
FRMD1FERM domain containing 1. (499 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (663 aa)
BMP6Bone morphogenetic protein 6. (511 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
TCF7L2Transcription factor 7 like 2. (632 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CTNNA3Catenin alpha-3. (895 aa)
PARD3Partitioning defective 3 homolog isoform 2. (1353 aa)
CTNNA2Catenin alpha 2. (953 aa)
MOB1AMps one binder kinase activator-like 1B. (216 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
DLG1Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
AMOTAngiomotin. (1099 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (315 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
CCN2Cellular communication network factor 2. (349 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
STK3Uncharacterized protein. (519 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform 1. (142 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
ID2Inhibitor of DNA binding 2. (203 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AFPAlpha fetoprotein. (609 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
BTRCUncharacterized protein. (629 aa)
PATJPATJ crumbs cell polarity complex component. (1882 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
APC2APC regulator of WNT signaling pathway 2. (2403 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
GLI2GLI family zinc finger 2. (1569 aa)
AJUBAAjuba LIM protein. (538 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
RASSF1Ras association domain family member 1. (345 aa)
DVL2Dishevelled segment polarity protein 2. (767 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CTNNB1Catenin beta-1. (781 aa)
SMAD7Mothers against decapentaplegic homolog. (462 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (499 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GDF6Growth differentiation factor 6. (455 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GDF5Growth differentiation factor 5. (499 aa)
LIMD1LIM domains containing 1. (676 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (407 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
WTIPWT1 interacting protein. (627 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
CSNK1DProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
AMHAnti-Mullerian hormone. (561 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LATS1Large tumor suppressor kinase 1. (1224 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
ITGB2Integrin beta. (911 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
PARD6APar-6 family cell polarity regulator alpha. (465 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
AXIN2Axin 2. (862 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF7Growth differentiation factor 7. (539 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1948 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1064 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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