STRINGSTRING
CLDN3 CLDN3 LLGL2 LLGL2 MAPK9 MAPK9 CLDN1 CLDN1 RDX RDX IGSF5 IGSF5 WHAMM WHAMM MAPK8 MAPK8 ARHGEF2 ARHGEF2 FNIP1 FNIP1 OCLN OCLN LOC707215 LOC707215 JAM3 JAM3 LOC705671 LOC705671 NF2 NF2 PRKAA2 PRKAA2 CLDN20 CLDN20 PRKAB2 PRKAB2 MICALL2 MICALL2 CLDN2 CLDN2 PPP2R2C PPP2R2C HCLS1 HCLS1 PARD6G PARD6G PRKCE PRKCE BVES BVES CLDN8 CLDN8 SYMPK SYMPK PRKAG1 PRKAG1 CLDN22 CLDN22 MYL9 MYL9 CLDN5 CLDN5 MYH14 MYH14 MAGI1 MAGI1 ITGB1 ITGB1 TJP1 TJP1 MPP4 MPP4 PRKCZ PRKCZ PRKAG3 PRKAG3 GATA4 GATA4 EZR EZR TUBA4A TUBA4A SRC SRC CD1D CD1D PRKACG PRKACG NDST1 NDST1 PPP2CB PPP2CB AFDN AFDN RAC1 RAC1 MPP5 MPP5 PPP2R1A PPP2R1A STK11 STK11 PPP2R2D PPP2R2D YBX3 YBX3 CDK4 CDK4 TTC33 TTC33 MYH11 MYH11 CLDN24 CLDN24 ACTR3B ACTR3B PARD3 PARD3 ROCK2 ROCK2 DLG2 DLG2 TUBA8 TUBA8 TUBA1A TUBA1A DLG1 DLG1 CLDN16 CLDN16 F11R F11R CD1A CD1A CD1E CD1E CDC42 CDC42 AMOT AMOT LOC697761 LOC697761 MAPK10 MAPK10 NEDD4L NEDD4L ACTG1 ACTG1 PPP2R2A PPP2R2A RAPGEF2 RAPGEF2 ARHGAP17 ARHGAP17 MARVELD2 MARVELD2 RHOA RHOA ACTN1 ACTN1 ROCK1 ROCK1 MYL6B MYL6B CLDN4 CLDN4 PPP2R1B PPP2R1B RAP2C RAP2C TJP2 TJP2 CACNA1D CACNA1D PATJ PATJ TJP3 TJP3 HSPA4 HSPA4 CLDN6 CLDN6 MAP3K5 MAP3K5 ACTN4 ACTN4 MARVELD3 MARVELD3 MYL6 MYL6 PRKACA PRKACA TUBA1C TUBA1C WAS WAS MYH9 MYH9 PRKAG2 PRKAG2 PPP2R2B PPP2R2B TIAM1 TIAM1 MYL2 MYL2 PRKACB PRKACB CLDN7 CLDN7 PCNA PCNA CLDN15 CLDN15 ERBB2 ERBB2 CD1C CD1C MYH10 MYH10 CD1B CD1B TJAP1 TJAP1 CGN CGN PARD6B PARD6B MPDZ MPDZ PRKCI PRKCI TUBAL3 TUBAL3 CLDN14 CLDN14 ACTR2 ACTR2 RAP1A RAP1A MSN MSN RAB8A RAB8A CLDN10 CLDN10 CLDN11 CLDN11 ACTR3 ACTR3 CFTR CFTR AMOTL1 AMOTL1 NEDD4 NEDD4 EPB41L4B EPB41L4B JUN JUN CRB3 CRB3 PARD6A PARD6A RUNX1 RUNX1 JAM2 JAM2 CGNL1 CGNL1 RAB13 RAB13 CLDN23 CLDN23 CLDN25 CLDN25 RAB8B RAB8B CLDN19 CLDN19 MYL12A MYL12A CCND1 CCND1 LLGL1 LLGL1 ARHGEF18 ARHGEF18 PRKAB1 PRKAB1 MAP3K1 MAP3K1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
RDXRadixin. (604 aa)
IGSF5Immunoglobulin superfamily member 5. (367 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (809 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1245 aa)
FNIP1Uncharacterized protein. (1651 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (546 aa)
LOC707215Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
JAM3Junctional adhesion molecule 3. (458 aa)
LOC705671Uncharacterized protein. (398 aa)
NF2Merlin isoform 1. (595 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
MICALL2MICAL like 2. (823 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (245 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (629 aa)
HCLS1SH3 domain-containing protein. (551 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
BVESBlood vessel epicardial substance. (360 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
SYMPKSymplekin. (1274 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
MYL9Myosin regulatory light polypeptide 9 isoform a. (172 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2035 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1470 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1860 aa)
MPP4Membrane palmitoylated protein 4; Belongs to the MAGUK family. (636 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
GATA4GATA binding protein 4. (443 aa)
EZREzrin. (598 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
SRCTyrosine-protein kinase. (644 aa)
CD1DIg-like domain-containing protein. (337 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
NDST1Uncharacterized protein. (1141 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
AFDNAfadin, adherens junction formation factor. (1892 aa)
RAC1Uncharacterized protein. (212 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (663 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
YBX3Y-box binding protein 3. (372 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2139 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
ACTR3BActin-related protein 3B isoform 1; Belongs to the actin family. (418 aa)
PARD3Partitioning defective 3 homolog isoform 2. (1353 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
DLG1Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
F11RJunctional adhesion molecule A. (299 aa)
CD1AIg-like domain-containing protein. (327 aa)
CD1ECD1e molecule. (437 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
AMOTAngiomotin. (1099 aa)
LOC697761Uncharacterized protein. (95 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1255 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1701 aa)
ARHGAP17Rho GTPase activating protein 17. (930 aa)
MARVELD2MARVEL domain containing 2. (559 aa)
RHOARas homolog family member A. (209 aa)
ACTN1Actinin alpha 1. (914 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
MYL6BMyosin light chain 6B. (209 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
RAP2CRas-related protein Rap-2c. (183 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1219 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PATJPATJ crumbs cell polarity complex component. (1882 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (915 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (840 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1483 aa)
ACTN4Actinin alpha 4. (911 aa)
MARVELD3MARVEL domain containing 3. (410 aa)
MYL6Myosin light chain 6. (160 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
WASWASP actin nucleation promoting factor. (503 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
TIAM1Uncharacterized protein. (1591 aa)
MYL2Myosin light chain 2. (166 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
ERBB2Receptor protein-tyrosine kinase. (1437 aa)
CD1CCD1c molecule. (332 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
CD1BCD1b molecule. (493 aa)
TJAP1Tight junction associated protein 1. (604 aa)
CGNCingulin. (1235 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2070 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (297 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MSNFERM domain-containing protein. (592 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1489 aa)
AMOTL1Angiomotin like 1. (986 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (909 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
CRB3Crumbs protein homolog 3 isoform b. (123 aa)
PARD6APar-6 family cell polarity regulator alpha. (465 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
JAM2Junctional adhesion molecule 2. (311 aa)
CGNL1Cingulin like 1. (1302 aa)
RAB13Uncharacterized protein. (245 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (289 aa)
CLDN25Claudin 25. (229 aa)
RAB8BRAB8B, member RAS oncogene family. (286 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
MYL12AUncharacterized protein. (232 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1064 aa)
ARHGEF18Uncharacterized protein. (1591 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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