STRINGSTRING
IRAK4 IRAK4 TLR5 TLR5 MYD88 MYD88 MAPK9 MAPK9 TLR6 TLR6 LY96 LY96 TOLLIP TOLLIP PIK3R2 PIK3R2 CD40 CD40 IFNAR1 IFNAR1 MAPK8 MAPK8 MAP3K8 MAP3K8 PIK3CA PIK3CA IRF7 IRF7 TBK1 TBK1 LOC100426632 LOC100426632 MAPK14 MAPK14 RIPK1 RIPK1 PIK3CB PIK3CB SPP1 SPP1 CD14 CD14 PIK3R1 PIK3R1 TAB1 TAB1 TLR9 TLR9 MAPK1 MAPK1 MAPK11 MAPK11 TLR7 TLR7 TLR8 TLR8 TAB2 TAB2 TLR2 TLR2 MAP2K1 MAP2K1 TRAF6 TRAF6 IRF5 IRF5 IRAK1 IRAK1 IFNB1 IFNB1 AKT3 AKT3 CXCL10 CXCL10 RAC1 RAC1 IL12B IL12B TLR3 TLR3 IL12A IL12A LOC694631 LOC694631 TICAM1 TICAM1 IKBKB IKBKB MAP3K7 MAP3K7 NFKB1 NFKB1 MAP2K3 MAP2K3 CASP8 CASP8 IKBKE IKBKE TLR4 TLR4 IKBKG IKBKG MAPK10 MAPK10 LOC710751 LOC710751 CHUK CHUK CXCL9 CXCL9 MAP2K4 MAP2K4 LOC100423954 LOC100423954 IL6 IL6 CD86 CD86 MAPK3 MAPK3 NFKBIA NFKBIA RELA RELA LOC100426537 LOC100426537 TNF TNF STAT1 STAT1 AKT2 AKT2 MAP2K6 MAP2K6 PIK3R3 PIK3R3 AKT1 AKT1 FADD FADD LOC710568 LOC710568 IFNA14 IFNA14 CCL3 CCL3 TRAF3 TRAF3 CXCL11 CXCL11 IFNA6 IFNA6 PIK3CD PIK3CD MAP2K2 MAP2K2 TIRAP TIRAP FOS FOS CXCL8 CXCL8 IFNA10 IFNA10 IFNA8 IFNA8 CCL5 CCL5 JUN JUN CD80 CD80 IFNA13 IFNA13 TLR1 TLR1 IFNAR2 IFNAR2 IL1B IL1B LBP LBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (831 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TLR6Toll-like receptor. (796 aa)
LY96MD2 protein. (160 aa)
TOLLIPToll interacting protein. (276 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (597 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (572 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IRF7Interferon regulatory factor 7. (504 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
LOC100426632C-C motif chemokine. (92 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa)
TLR9TIR domain-containing protein. (1032 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1040 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
IRF5Interferon regulatory factor 5. (631 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (725 aa)
IFNB1Interferon beta 1. (187 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CXCL10C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
RAC1Uncharacterized protein. (212 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (379 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
LOC694631Uncharacterized protein. (190 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (620 aa)
NFKB1Uncharacterized protein. (977 aa)
MAP2K3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC710751Uncharacterized protein. (189 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CXCL9C-X-C motif chemokine ligand 9. (201 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
LOC100423954C-C motif chemokine. (93 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
CD86CD86 molecule. (417 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
LOC100426537C-C motif chemokine. (67 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
PIK3R3Uncharacterized protein. (507 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LOC710568Interferon alpha 16. (189 aa)
IFNA14Interferon alpha 14. (189 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity). (92 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CXCL11C-X-C motif chemokine. (94 aa)
IFNA6Interferon alpha-6. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IFNA10Uncharacterized protein. (189 aa)
IFNA8Interferon alpha-8. (189 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
CD80CD80 molecule. (288 aa)
IFNA13Uncharacterized protein. (190 aa)
TLR1Toll-like receptor. (786 aa)
IFNAR2Uncharacterized protein. (684 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
LBPLipopolysaccharide binding protein. (508 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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