Your Input: | |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (185 aa) |
| | GBP7 | Guanylate binding protein 7. (647 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | GPRC6A | G protein-coupled receptor class C group 6 member A. (928 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (597 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | MFN1 | Mitofusin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa) |
| | TRPM2 | Transient receptor potential cation channel subfamily M member 2. (1539 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | MNDA | Gamma-interferon-inducible protein 16 isoform 2. (729 aa) |
| | PANX1 | Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (470 aa) |
| | RNASEL | Ribonuclease L. (741 aa) |
| | BCL2L1 | Bcl-2-like protein 1 isoform 1. (233 aa) |
| | DHX33 | DEAH-box helicase 33. (766 aa) |
| | IRF7 | Interferon regulatory factor 7. (504 aa) |
| | SHARPIN | Sharpin. (382 aa) |
| | LOC694235 | Defensin, beta 103. (67 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | CXCL1 | C-X-C motif chemokine. (107 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (719 aa) |
| | CASP4 | Caspase-4 isoform alpha; Belongs to the peptidase C14A family. (377 aa) |
| | GABARAP | Gamma-aminobutyric acid receptor-associated protein. (117 aa) |
| | CAMP | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. (173 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | STING1 | Stimulator of interferon protein. (379 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa) |
| | NLRX1 | NLR family member X1. (972 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (488 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa) |
| | DNM1L | Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa) |
| | TRPV2 | Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa) |
| | TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa) |
| | SUGT1 | Uncharacterized protein. (401 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | MAVS | Mitochondrial antiviral-signaling protein isoform 1. (541 aa) |
| | DEFA4 | DEFENSIN domain-containing protein. (94 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (786 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | DEFA1B | Neutrophil defensin 1; Has bacteriostatic activity against Gram-positive bacteria S.aureus and L.monocytogenes and Gram-negative bacterium E.coli and antifungal activity against C.neoformans. Has microbicidial activity against Gram-positive bacteria S.aureus and L.monocytogenes. (96 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | GBP3 | Guanylate binding protein 3. (595 aa) |
| | MCU | Mitochondrial calcium uniporter. (351 aa) |
| | TRIP6 | Thyroid receptor-interacting protein 6. (476 aa) |
| | CARD18 | Caspase recruitment domain family member 18. (91 aa) |
| | NEK7 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (381 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | LOC694631 | Uncharacterized protein. (190 aa) |
| | NFKBIB | NF-kappa-B inhibitor beta isoform a. (356 aa) |
| | CARD6 | Caspase recruitment domain family member 6. (1037 aa) |
| | NLRP7 | Uncharacterized protein. (1009 aa) |
| | GSDMD | Gasdermin D. (529 aa) |
| | TICAM1 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | ERBIN | Erbb2 interacting protein. (1418 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | LOC106996371 | VWFA domain-containing protein. (658 aa) |
| | ANTXR1 | ANTXR cell adhesion molecule 1. (583 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa) |
| | PYDC2 | PYRIN-only protein 2. (139 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (573 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1061 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | VDAC3 | Uncharacterized protein. (299 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (399 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1102 aa) |
| | LOC718594 | Uncharacterized protein. (533 aa) |
| | LOC710751 | Uncharacterized protein. (189 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3. (790 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | RHOA | Ras homolog family member A. (209 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | MFN2 | Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | NLRP6 | Uncharacterized protein. (1044 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa) |
| | PSTPIP1 | Proline-serine-threonine phosphatase interacting protein 1. (492 aa) |
| | YWHAE | 14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) |
| | LOC114680396 | DEFSN domain-containing protein. (64 aa) |
| | CASP12 | Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution; Belongs to the peptidase C14A family. (430 aa) |
| | GABARAPL1 | Uncharacterized protein. (146 aa) |
| | NLRP1 | Uncharacterized protein. (1537 aa) |
| | PKN2 | Protein kinase N2. (981 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | NLRP3 | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] (1035 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | PKN1 | Protein kinase N1. (1013 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | STAT1 | Signal transducer and activator of transcription. (802 aa) |
| | TANK | TRAF family member-associated NF-kappa-B activator isoform a. (425 aa) |
| | TAB3 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3. (712 aa) |
| | LOC702827 | Uncharacterized protein. (117 aa) |
| | NAMPT | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa) |
| | CASR | Calcium sensing receptor. (1078 aa) |
| | ANTXR2 | Anthrax toxin receptor; Belongs to the ATR family. (498 aa) |
| | RTD1A | Rhesus theta defensin-1/3 subunit A; RTD-1 and RTD-3 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram- negative bacteria S.typhimurium and E.coli ML35, and the fungi C.albicans 16820 and C.neoformans 271A; Belongs to the alpha-defensin family. Theta subfamily. (76 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | LOC710568 | Interferon alpha 16. (189 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (535 aa) |
| | RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 isoform 2. (510 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | DEFA6 | Defensin, alpha 6. (100 aa) |
| | TXN2 | Thioredoxin domain-containing protein. (169 aa) |
| | LOC114676064 | DEFSN domain-containing protein. (64 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1403 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | IRF9 | Interferon regulatory factor 9. (455 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (462 aa) |
| | TYK2 | Tyrosine-protein kinase. (1196 aa) |
| | LOC718576 | FIIND domain-containing protein. (414 aa) |
| | CTSB | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (453 aa) |
| | IFNA6 | Interferon alpha-6. (189 aa) |
| | LOC703390 | C-X-C motif chemokine. (198 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa) |
| | BCL2 | BCL2 apoptosis regulator. (241 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | IFNA10 | Uncharacterized protein. (189 aa) |
| | IFNA8 | Interferon alpha-8. (189 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) |
| | GABARAPL2 | Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (195 aa) |
| | CYBB | Cytochrome b-245 beta chain. (617 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | BIRC2 | Baculoviral IAP repeat-containing protein 2. (618 aa) |
| | RNF31 | Uncharacterized protein. (1146 aa) |
| | SLC29A1 | HATPase_c domain-containing protein. (1077 aa) |
| | PRKCD | Protein kinase C. (729 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (308 aa) |
| | RTD1B | Rhesus theta defensin-1/2 subunit B; RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram- negative bacterium S.typhimurium, and the fungi C.albicans 16820 and C.neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E.coli ML35; Belongs to the alpha-defensin family. Theta subfamily. (76 aa) |
| | CXCL3 | C-X-C motif chemokine. (318 aa) |
| | TXNIP | Thioredoxin-interacting protein. (391 aa) |
| | IFNA13 | Uncharacterized protein. (190 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | Defb2L4 | B-defensin2-like protein 4. (64 aa) |
| | VDAC1 | Voltage-dependent anion-selective channel protein 1. (283 aa) |
| | IFNAR2 | Uncharacterized protein. (684 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | TRPM7 | Transient receptor potential cation channel subfamily M member 7. (2379 aa) |
| | LOC114675435 | Beta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells; Belongs to the beta-defensin family. LAP/TAP subfamily. (64 aa) |
| | HSP90AA1 | HATPase_c domain-containing protein. (733 aa) |
