STRINGSTRING
AZI2 AZI2 MAPK9 MAPK9 MAPK8 MAPK8 IRF7 IRF7 TBK1 TBK1 MAPK14 MAPK14 RIPK1 RIPK1 TRAF2 TRAF2 STING1 STING1 NLRX1 NLRX1 CYLD CYLD DDX58 DDX58 MAPK11 MAPK11 DHX58 DHX58 MAVS MAVS TRAF6 TRAF6 IFNB1 IFNB1 CXCL10 CXCL10 IL12B IL12B IL12A IL12A LOC694631 LOC694631 NFKBIB NFKBIB IKBKB IKBKB MAP3K7 MAP3K7 NFKB1 NFKB1 CASP8 CASP8 IKBKE IKBKE SIKE1 SIKE1 IKBKG IKBKG MAPK10 MAPK10 LOC710751 LOC710751 DDX3X DDX3X CHUK CHUK OTUD5 OTUD5 RNF125 RNF125 TKFC TKFC CASP10 CASP10 NFKBIA NFKBIA RELA RELA TNF TNF TANK TANK IFNK IFNK FADD FADD LOC710568 LOC710568 IFNA14 IFNA14 IFNW1 IFNW1 TRAF3 TRAF3 IFNA6 IFNA6 ATG12 ATG12 TRADD TRADD CXCL8 CXCL8 IFNA10 IFNA10 IFNA8 IFNA8 PIN1 PIN1 TBKBP1 TBKBP1 IFNA13 IFNA13 ISG15 ISG15 COIL COIL MAP3K1 MAP3K1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AZI25-azacytidine induced 2. (394 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
IRF7Interferon regulatory factor 7. (504 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
STING1Stimulator of interferon protein. (379 aa)
NLRX1NLR family member X1. (972 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
DDX58Putative ATP-dependent RNA helicase DDX58. (925 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
DHX58DExH-box helicase 58. (678 aa)
MAVSMitochondrial antiviral-signaling protein isoform 1. (541 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
IFNB1Interferon beta 1. (187 aa)
CXCL10C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (379 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
LOC694631Uncharacterized protein. (190 aa)
NFKBIBNF-kappa-B inhibitor beta isoform a. (356 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (620 aa)
NFKB1Uncharacterized protein. (977 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa)
SIKE1Suppressor of IKBKE 1. (211 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC710751Uncharacterized protein. (189 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
OTUD5OTU deubiquitinase 5. (566 aa)
RNF125E3 ubiquitin-protein ligase RNF125. (232 aa)
TKFCTriokinase and FMN cyclase. (598 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (520 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform a. (425 aa)
IFNKInterferon kappa. (207 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LOC710568Interferon alpha 16. (189 aa)
IFNA14Interferon alpha 14. (189 aa)
IFNW1Interferon alpha-II-1. (195 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IFNA6Interferon alpha-6. (189 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IFNA10Uncharacterized protein. (189 aa)
IFNA8Interferon alpha-8. (189 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
TBKBP1TBK1 binding protein 1. (669 aa)
IFNA13Uncharacterized protein. (190 aa)
ISG15Ubiquitin-like protein ISG15. (165 aa)
COILTripartite motif containing 25. (899 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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