STRINGSTRING
IL12RB2 IL12RB2 MAPK9 MAPK9 IL5 IL5 IL13 IL13 IL4 IL4 RBPJL RBPJL STAT5B STAT5B MAPK8 MAPK8 IL2RB IL2RB STAT4 STAT4 GATA3 GATA3 MAPK14 MAPK14 JAK3 JAK3 IL12RB1 IL12RB1 MAPK1 MAPK1 NOTCH3 NOTCH3 MAPK11 MAPK11 PPP3CC PPP3CC JAK2 JAK2 MAML2 MAML2 IL2RA IL2RA PPP3CB PPP3CB NOTCH1 NOTCH1 CD3D CD3D IL2RG IL2RG JAG1 JAG1 JAK1 JAK1 DLL3 DLL3 MAMU-DPA MAMU-DPA PRKCQ PRKCQ IL2 IL2 DLL1 DLL1 ZAP70 ZAP70 IL12B IL12B NFATC3 NFATC3 MAML3 MAML3 NFKBIE NFKBIE IL12A IL12A NFKBIB NFKBIB IKBKB IKBKB MAMU-DMA MAMU-DMA NFKB1 NFKB1 IKBKG IKBKG MAPK10 MAPK10 CHUK CHUK LCK LCK NOTCH2 NOTCH2 NFATC2 NFATC2 STAT5A STAT5A HLA-DRA HLA-DRA MAPK3 MAPK3 CD3G CD3G NFKBIA NFKBIA RELA RELA RBPJ RBPJ PLCG1 PLCG1 STAT1 STAT1 CD247 CD247 MAML1 MAML1 PPP3R1 PPP3R1 RUNX3 RUNX3 STAT6 STAT6 CD3E CD3E TBX21 TBX21 IFNG IFNG DLL4 DLL4 TYK2 TYK2 IL4R IL4R LOC710149 LOC710149 CD4 CD4 FOS FOS IFNGR2 IFNGR2 IFNGR1 IFNGR1 LOC114669810 LOC114669810 JUN JUN MAMU-DOA MAMU-DOA JAG2 JAG2 HLA-DRB5 HLA-DRB5 ENSMMUP00000076578 ENSMMUP00000076578 MAF MAF NFATC1 NFATC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL12RB2Interleukin 12 receptor subunit beta 2. (863 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (132 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
STAT4Signal transducer and activator of transcription. (742 aa)
GATA3GATA binding protein 3. (444 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
JAK3Janus kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (602 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (789 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NOTCH3Notch receptor 3. (2321 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
MAML2Mastermind like transcriptional coactivator 2. (1151 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (338 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
NOTCH1Notch receptor 1. (2556 aa)
CD3DIg_4 domain-containing protein. (171 aa)
IL2RGCytokine receptor common subunit gamma. (369 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
MAMU-DPAMHC class II antigen; Belongs to the MHC class II family. (260 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (739 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (379 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
MAML3Mastermind like transcriptional coactivator 3. (1133 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NFKBIBNF-kappa-B inhibitor beta isoform a. (356 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
MAMU-DMAIg-like domain-containing protein. (276 aa)
NFKB1Uncharacterized protein. (977 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LCKTyrosine-protein kinase. (567 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
HLA-DRAMamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (378 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CD3GCD3g molecule. (209 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
RBPJUncharacterized protein. (500 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
CD247CD247 molecule. (224 aa)
MAML1Mastermind like transcriptional coactivator 1. (1014 aa)
PPP3R1Uncharacterized protein. (171 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
STAT6Signal transducer and activator of transcription. (902 aa)
CD3ECD3e molecule. (217 aa)
TBX21T-box transcription factor 21. (539 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
TYK2Tyrosine-protein kinase. (1196 aa)
IL4RInterleukin 4 receptor. (825 aa)
LOC710149Ig-like domain-containing protein. (228 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
IFNGR2Interferon gamma receptor 2. (336 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
LOC114669810Ig-like domain-containing protein; Belongs to the MHC class II family. (266 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
MAMU-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1290 aa)
HLA-DRB5Ig-like domain-containing protein. (287 aa)
ENSMMUP00000076578Ig-like domain-containing protein. (275 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (403 aa)
NFATC1Nuclear factor of activated T cells 1. (943 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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