60 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (668 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
	GRM5	Metabotropic glutamate receptor 5 isoform a. (1212 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (511 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
	CALML5	Calmodulin-like protein 5. (146 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	PRKACG	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (735 aa)
	HRAS	Transforming protein p21. (189 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (763 aa)
	CALML6	Calmodulin like 6. (181 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (860 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	RAP1B	Ras-related protein Rap-1b isoform 1. (184 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	CALML3	Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (923 aa)
	RAF1	Uncharacterized protein. (668 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
	GRIA1	Uncharacterized protein. (916 aa)
	PPP3R1	Uncharacterized protein. (171 aa)
	GRIA2	Uncharacterized protein. (883 aa)
	GNAQ	Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	CAMK4	Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
	CREBBP	CREB-binding protein isoform a. (2442 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha. (622 aa)
	ATF4	BZIP domain-containing protein. (351 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	CALM2	Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
	EP300	Histone acetyltransferase p300. (2414 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (194 aa)
	GRM1	Metabotropic glutamate receptor 1 isoform alpha. (1195 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY8	ENSMMUP00000069811	ENSMMUP00000044242	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.951
ADCY1	CALM2	ENSMMUP00000069811	ENSMMUP00000076065	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.936
ADCY1	CALM3	ENSMMUP00000069811	ENSMMUP00000076991	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.942
ADCY1	CALML3	ENSMMUP00000069811	ENSMMUP00000053471	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-related protein NB-1; Belongs to the calmodulin family.	0.954
ADCY1	CALML5	ENSMMUP00000069811	ENSMMUP00000022969	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 5.	0.977
ADCY1	CALML6	ENSMMUP00000069811	ENSMMUP00000045683	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.943
ADCY1	CAMK2A	ENSMMUP00000069811	ENSMMUP00000068951	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha.	0.718
ADCY1	CAMK2B	ENSMMUP00000069811	ENSMMUP00000003272	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.761
ADCY1	CAMK2G	ENSMMUP00000069811	ENSMMUP00000028185	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II gamma.	0.742
ADCY1	CAMK4	ENSMMUP00000069811	ENSMMUP00000062553	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily.	0.726
ADCY1	PRKACA	ENSMMUP00000069811	ENSMMUP00000054168	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.932
ADCY1	PRKACB	ENSMMUP00000069811	ENSMMUP00000059748	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily.	0.940
ADCY1	PRKACG	ENSMMUP00000069811	ENSMMUP00000026815	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	0.932
ADCY1	PRKCA	ENSMMUP00000069811	ENSMMUP00000070240	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.726
ADCY1	PRKCB	ENSMMUP00000069811	ENSMMUP00000061909	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.678
ADCY1	PRKCG	ENSMMUP00000069811	ENSMMUP00000031468	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.688
ADCY1	RAPGEF3	ENSMMUP00000069811	ENSMMUP00000056387	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.925
ADCY8	ADCY1	ENSMMUP00000044242	ENSMMUP00000069811	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.951
ADCY8	CALM2	ENSMMUP00000044242	ENSMMUP00000076065	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.908
ADCY8	CALM3	ENSMMUP00000044242	ENSMMUP00000076991	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.937