STRINGSTRING
GNG13 GNG13 PPP2R3A PPP2R3A MAPK9 MAPK9 CLOCK CLOCK CAMK2B CAMK2B DRD5 DRD5 CACNA1A CACNA1A TH TH MAPK8 MAPK8 GNB4 GNB4 PLCB1 PLCB1 GRIA4 GRIA4 PPP2R3B PPP2R3B DRD1 DRD1 GNB3 GNB3 GNAI3 GNAI3 KCNJ3 KCNJ3 PPP2R5E PPP2R5E MAPK14 MAPK14 GRIA3 GRIA3 CACNA1B CACNA1B KIF5C KIF5C LOC694289 LOC694289 KIF5B KIF5B PLCB3 PLCB3 CACNA1C CACNA1C PPP2R2C PPP2R2C PPP1CC PPP1CC MAPK11 MAPK11 DRD2 DRD2 PPP3CC PPP3CC PPP3CB PPP3CB CREB3L2 CREB3L2 PPP1CA PPP1CA GNB5 GNB5 CALML5 CALML5 CREB3L1 CREB3L1 GRIN2B GRIN2B MAOA MAOA PPP2R3C PPP2R3C GNAO1 GNAO1 CREB3L3 CREB3L3 DDC DDC AKT3 AKT3 SLC18A1 SLC18A1 GNAI2 GNAI2 PRKACG PRKACG PPP1CB PPP1CB PPP2CB PPP2CB CAMK2G CAMK2G PPP2R1A PPP2R1A GNG5 GNG5 PPP2R2D PPP2R2D DRD3 DRD3 GNAI1 GNAI1 PRKCG PRKCG KCNJ6 KCNJ6 CREB1 CREB1 CREB3L4 CREB3L4 ITPR2 ITPR2 CREB5 CREB5 MAPK10 MAPK10 KIF5A KIF5A ITPR3 ITPR3 PPP2R2A PPP2R2A CALML6 CALML6 GRIN2A GRIN2A ITPR1 ITPR1 ATF2 ATF2 GNGT1 GNGT1 PPP2R1B PPP2R1B CACNA1D CACNA1D GNG11 GNG11 GNG3 GNG3 SLC18A2 SLC18A2 ADCY5 ADCY5 SCN1A SCN1A CALML3 CALML3 PPP2R5B PPP2R5B PRKACA PRKACA ATF6B ATF6B PPP2R5C PPP2R5C PPP2R2B PPP2R2B AKT2 AKT2 PRKACB PRKACB GRIA1 GRIA1 GSK3B GSK3B PPP2R5D PPP2R5D GRIA2 GRIA2 AKT1 AKT1 GNAQ GNAQ PRKCB PRKCB PLCB4 PLCB4 CREB3 CREB3 KCNJ5 KCNJ5 SLC6A3 SLC6A3 COMT COMT GNB1 GNB1 ARRB2 ARRB2 KCNJ9 KCNJ9 GNG7 GNG7 PLCB2 PLCB2 CAMK2A CAMK2A ARNTL ARNTL MAOB MAOB ATF4 ATF4 PRKCA PRKCA GNB2 GNB2 FOS FOS PPP2R5A PPP2R5A GNAL GNAL CALY CALY ENSMMUP00000075823 ENSMMUP00000075823 CALM2 CALM2 CALM3 CALM3 ARRB1 ARRB1 PPP1R1B PPP1R1B
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1120 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CLOCKClock circadian regulator. (852 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
DRD5D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (478 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2411 aa)
THTyrosine hydroxylase. (501 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (884 aa)
PPP2R3BEF-hand domain-containing protein. (572 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (471 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2338 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
LOC694289Uncharacterized protein. (394 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (629 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
GNB5G protein subunit beta 5. (395 aa)
CALML5Calmodulin-like protein 5. (146 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
MAOAAmine oxidase. (969 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform a. (354 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (603 aa)
DDCAromatic-L-amino-acid decarboxylase. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
DRD3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa)
GNAI1G protein subunit alpha i1. (422 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
KIF5AKinesin heavy chain isoform 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
CALML6Calmodulin like 6. (181 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (716 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (505 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
GRIA1Uncharacterized protein. (916 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
GRIA2Uncharacterized protein. (883 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (372 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (469 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
COMTCatechol-O-methyltransferase. (376 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
ARRB2Arrestin beta 2. (575 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (468 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a. (626 aa)
MAOBAmine oxidase. (520 aa)
ATF4BZIP domain-containing protein. (351 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
GNALUncharacterized protein. (450 aa)
CALYNeuron-specific vesicular protein calcyon. (218 aa)
ENSMMUP00000075823Uncharacterized protein. (290 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
ARRB1Arrestin beta 1. (529 aa)
PPP1R1BUncharacterized protein. (433 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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