STRINGSTRING
PRKAR2A PRKAR2A PPP1R3C PPP1R3C PDE3B PDE3B MAPK9 MAPK9 KRAS KRAS EIF4EBP1 EIF4EBP1 HK3 HK3 TSC2 TSC2 PIK3R2 PIK3R2 HKDC1 HKDC1 HK1 HK1 GYS1 GYS1 MAPK8 MAPK8 PIK3CA PIK3CA RHOQ RHOQ RPS6KB2 RPS6KB2 SHC1 SHC1 RPTOR RPTOR PTPN1 PTPN1 PIK3CB PIK3CB TRIP10 TRIP10 EXOC7 EXOC7 ACACA ACACA TSC1 TSC1 SH2B2 SH2B2 PRKAA2 PRKAA2 INPPL1 INPPL1 SOCS1 SOCS1 MKNK2 MKNK2 PDPK1 PDPK1 PIK3R1 PIK3R1 PRKAB2 PRKAB2 MAPK1 MAPK1 FLOT2 FLOT2 FASN FASN LOC712274 LOC712274 PPP1CC PPP1CC G6PC2 G6PC2 FLOT1 FLOT1 PPP1R3E PPP1R3E PRKAR2B PRKAR2B PRKAG1 PRKAG1 GYS2 GYS2 MAP2K1 MAP2K1 PPP1CA PPP1CA CALML5 CALML5 LIPE LIPE PRKCZ PRKCZ PRKAG3 PRKAG3 ELK1 ELK1 PPP1R3D PPP1R3D AKT3 AKT3 PRKACG PRKACG PPP1CB PPP1CB PHKG2 PHKG2 PCK2 PCK2 HRAS HRAS IRS2 IRS2 EIF4E2 EIF4E2 FBP1 FBP1 PCK1 PCK1 PYGM PYGM PPP1R3A PPP1R3A TTC33 TTC33 IKBKB IKBKB SLC2A4 SLC2A4 FOXO1 FOXO1 PYGB PYGB INS INS PHKA2 PHKA2 LOC114672301 LOC114672301 MAPK10 MAPK10 CRK CRK BRAF BRAF IRS1 IRS1 GRB2 GRB2 CALML6 CALML6 SOS2 SOS2 SHC3 SHC3 G6PC G6PC NRAS NRAS GCK GCK SREBF1 SREBF1 MAPK3 MAPK3 CALML3 CALML3 PRKACA PRKACA SHC4 SHC4 PYGL PYGL PRKAG2 PRKAG2 RAF1 RAF1 CBL CBL AKT2 AKT2 PRKACB PRKACB PHKA1 PHKA1 PPARGC1A PPARGC1A PIK3R3 PIK3R3 GSK3B GSK3B AKT1 AKT1 PHKB PHKB PTPRF PTPRF RHEB RHEB FBP2 FBP2 SOCS3 SOCS3 SOCS2 SOCS2 SOS1 SOS1 BAD BAD PPP1R3B PPP1R3B PIK3CD PIK3CD G6PC3 G6PC3 PRKCI PRKCI MAP2K2 MAP2K2 ACACB ACACB CBLB CBLB RAPGEF1 RAPGEF1 MTOR MTOR ARAF ARAF HK2 HK2 INPP5A INPP5A PRKAR1B PRKAR1B CALM2 CALM2 CALM3 CALM3 PRKAR1A PRKAR1A PPP1R3F PPP1R3F PKLR PKLR PRKAB1 PRKAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PDE3BPhosphodiesterase. (1117 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
HK3Hexokinase 3. (923 aa)
TSC2TSC complex subunit 2. (2057 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (921 aa)
GYS1Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family. (737 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RHOQRas homolog family member Q. (233 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (512 aa)
SHC1SHC-transforming protein 1 isoform 3. (584 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TRIP10Thyroid hormone receptor interactor 10. (597 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (720 aa)
ACACAAcetyl-CoA carboxylase alpha. (2332 aa)
TSC1TSC complex subunit 1. (1164 aa)
SH2B2SH2B adaptor protein 2. (680 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1315 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2; Belongs to the protein kinase superfamily. (465 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
FASNFatty acid synthase. (2576 aa)
LOC71227440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (439 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
CALML5Calmodulin-like protein 5. (146 aa)
LIPELipase E, hormone sensitive type. (1072 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, testis/liver isoform isoform 1; Belongs to the protein kinase superfamily. (406 aa)
PCK2Uncharacterized protein. (644 aa)
HRASTransforming protein p21. (189 aa)
IRS2Insulin receptor substrate 2. (1394 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (467 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1145 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
FOXO1Forkhead box O1. (655 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1186 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
LOC114672301ETS domain-containing protein. (488 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CALML6Calmodulin like 6. (181 aa)
SOS2Uncharacterized protein. (1332 aa)
SHC3Uncharacterized protein. (596 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GCKPhosphotransferase. (466 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
SHC4Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
RAF1Uncharacterized protein. (668 aa)
CBLE3 ubiquitin-protein ligase CBL. (907 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1223 aa)
PPARGC1APPARG coactivator 1 alpha. (818 aa)
PIK3R3Uncharacterized protein. (507 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1918 aa)
RHEBUncharacterized protein. (249 aa)
FBP2FBPase domain-containing protein; Belongs to the FBPase class 1 family. (345 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
BADBcl2 antagonist of cell death. (167 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
ACACBAcetyl-CoA carboxylase beta. (2486 aa)
CBLBCbl proto-oncogene B. (982 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1297 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
HK2Hexokinase 2. (917 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (450 aa)
PRKAR1BCyclic nucleotide-binding domain-containing protein. (494 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (798 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (579 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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