(85 nodes) Progesterone-mediated oocyte maturation network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDE3B	Phosphodiesterase. (1117 aa)
	CPEB2	Cytoplasmic polyadenylation element binding protein 2. (1037 aa)
	CDC23	Cell division cycle protein 23 homolog. (597 aa)
	ANAPC2	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (822 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	PKMYT1	Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (499 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	GNAI3	Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	CDC25C	Cell division cycle 25C. (507 aa)
	KIF22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (670 aa)
	CCNA2	Cyclin-A2; Belongs to the cyclin family. (432 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PGR	Uncharacterized protein. (936 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	MOS	Proto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (346 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PLK1	Serine/threonine-protein kinase PLK. (603 aa)
	CDC27	Cell division cycle protein 27 homolog isoform 1. (830 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (493 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	SPDYC	Speedy/RINGO cell cycle regulator family member C. (293 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
	PRKACG	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
	ADCY4	Adenylate cyclase 4. (1299 aa)
	CDC25A	M-phase inducer phosphatase 1 isoform a. (524 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	SPDYE4	Uncharacterized protein. (237 aa)
	LOC718058	Uncharacterized protein. (307 aa)
	GNAI1	G protein subunit alpha i1. (422 aa)
	CCNB1	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa)
	ANAPC4	Anaphase promoting complex subunit 4. (981 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	CDC16	Cell division cycle protein 16 homolog. (620 aa)
	SPDYA	Speedy/RINGO cell cycle regulator family member A. (313 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	AURKA	Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
	ANAPC5	Anaphase-promoting complex subunit 5 isoform a. (755 aa)
	CDK2	Diacylglycerol kinase. (1053 aa)
	CCNA1	Cyclin-A1 isoform a; Belongs to the cyclin family. (465 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	CDC25B	Cell division cycle 25B. (570 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (763 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (860 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1085 aa)
	ADCY5	Adenylate cyclase 5. (1263 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
	RAF1	Uncharacterized protein. (668 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (768 aa)
	CCNB3	Cyclin B3; Belongs to the cyclin family. (1362 aa)
	CPEB1	Uncharacterized protein. (584 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (398 aa)
	AKT2	AKT serine/threonine kinase 2. (594 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
	PIK3R3	Uncharacterized protein. (507 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (718 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
	ANAPC1	Anaphase promoting complex subunit 1. (2016 aa)
	MAD2L1	Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
	STK10	Serine/threonine kinase 10. (996 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (599 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	SLC29A1	HATPase_c domain-containing protein. (1077 aa)
	CDC26	Anaphase-promoting complex subunit CDC26. (85 aa)
	ANAPC13	Anaphase-promoting complex subunit 13. (74 aa)
	HSP90AA1	HATPase_c domain-containing protein. (733 aa)
	CPEB4	Cytoplasmic polyadenylation element-binding protein 4. (729 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMMUP00000069811	ENSMMUP00000059741	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.486
ADCY1	ADCY3	ENSMMUP00000069811	ENSMMUP00000049332	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.945
ADCY1	ADCY4	ENSMMUP00000069811	ENSMMUP00000027242	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 4.	0.468
ADCY1	ADCY5	ENSMMUP00000069811	ENSMMUP00000052487	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5.	0.457
ADCY1	ADCY6	ENSMMUP00000069811	ENSMMUP00000064485	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.441
ADCY1	ADCY7	ENSMMUP00000069811	ENSMMUP00000075019	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.509
ADCY1	ADCY8	ENSMMUP00000069811	ENSMMUP00000044242	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.951
ADCY1	ADCY9	ENSMMUP00000069811	ENSMMUP00000068875	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.663
ADCY1	AKT1	ENSMMUP00000069811	ENSMMUP00000061388	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.694
ADCY1	AKT2	ENSMMUP00000069811	ENSMMUP00000059674	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AKT serine/threonine kinase 2.	0.694
ADCY1	AKT3	ENSMMUP00000069811	ENSMMUP00000026292	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.694
ADCY1	GNAI1	ENSMMUP00000069811	ENSMMUP00000030898	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.809
ADCY1	GNAI2	ENSMMUP00000069811	ENSMMUP00000026482	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1.	0.802
ADCY1	GNAI3	ENSMMUP00000069811	ENSMMUP00000007669	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.809
ADCY1	PDE3B	ENSMMUP00000069811	ENSMMUP00000001027	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.767
ADCY1	PRKACA	ENSMMUP00000069811	ENSMMUP00000054168	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.932
ADCY1	PRKACB	ENSMMUP00000069811	ENSMMUP00000059748	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily.	0.940
ADCY1	PRKACG	ENSMMUP00000069811	ENSMMUP00000026815	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	0.932
ADCY2	ADCY1	ENSMMUP00000059741	ENSMMUP00000069811	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.486
ADCY2	ADCY4	ENSMMUP00000059741	ENSMMUP00000027242	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 4.	0.427