STRINGSTRING
KRT40 KRT40 KRT25 KRT25 KRT27 KRT27 KRT28 KRT28 KRT10 KRT10 KRT12 KRT12 KRT20 KRT20 KRT23 KRT23 KRT39 KRT39 KRAS KRAS PIK3R2 PIK3R2 PLCB1 PLCB1 KRT33A KRT33A PIK3CA PIK3CA GNAI3 GNAI3 SHC1 SHC1 KCNJ3 KCNJ3 FKBP4 FKBP4 KRT9 KRT9 PIK3CB PIK3CB KRT16 KRT16 LOC694289 LOC694289 KRT31 KRT31 KRT34 KRT34 KRT33B KRT33B FKBP5 FKBP5 PIK3R1 PIK3R1 PGR PGR RARA RARA MAPK1 MAPK1 PLCB3 PLCB3 NCOA2 NCOA2 MMP9 MMP9 CREB3L2 CREB3L2 MAP2K1 MAP2K1 CALML5 CALML5 KRT18 KRT18 CREB3L1 CREB3L1 KRT37 KRT37 KRT32 KRT32 KRT35 KRT35 KRT36 KRT36 KRT19 KRT19 GNAO1 GNAO1 CREB3L3 CREB3L3 AKT3 AKT3 GNAI2 GNAI2 SRC SRC PRKACG PRKACG NOS3 NOS3 ADCY4 ADCY4 HRAS HRAS ESR2 ESR2 HSP90B1 HSP90B1 GNAI1 GNAI1 KRT24 KRT24 EBAG9 EBAG9 HSPA1L HSPA1L GABBR1 GABBR1 KCNJ6 KCNJ6 CREB1 CREB1 CREB3L4 CREB3L4 ITPR2 ITPR2 CREB5 CREB5 KRT13 KRT13 ITPR3 ITPR3 OPRM1 OPRM1 ADCY8 ADCY8 GRB2 GRB2 CALML6 CALML6 TGFA TGFA EGFR EGFR SOS2 SOS2 ITPR1 ITPR1 ATF2 ATF2 SHC3 SHC3 ADCY3 ADCY3 GPER1 GPER1 NRAS NRAS MMP2 MMP2 ADCY5 ADCY5 MAPK3 MAPK3 CALML3 CALML3 PRKACA PRKACA SHC4 SHC4 HSPA8 HSPA8 KRT38 KRT38 ATF6B ATF6B RAF1 RAF1 AKT2 AKT2 ADCY2 ADCY2 PRKACB PRKACB PIK3R3 PIK3R3 AKT1 AKT1 GNAQ GNAQ HBEGF HBEGF PLCB4 PLCB4 GABBR2 GABBR2 CREB3 CREB3 ADCY6 ADCY6 KCNJ5 KCNJ5 CTSD CTSD SOS1 SOS1 KCNJ9 KCNJ9 NCOA1 NCOA1 PIK3CD PIK3CD PLCB2 PLCB2 ADCY9 ADCY9 ATF4 ATF4 ESR1 ESR1 MAP2K2 MAP2K2 ADCY1 ADCY1 BCL2 BCL2 FOS FOS HSPA1A HSPA1A JUN JUN ADCY7 ADCY7 SLC29A1 SLC29A1 CALM2 CALM2 PRKCD PRKCD TFF1 TFF1 CALM3 CALM3 NCOA3 NCOA3 SP1 SP1 HSP90AA1 HSP90AA1 GRM1 GRM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT40Keratin 40; Belongs to the intermediate filament family. (431 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
KRT27Keratin 27; Belongs to the intermediate filament family. (459 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (464 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (565 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (495 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (424 aa)
KRT23Cytokeratin-23; Belongs to the intermediate filament family. (422 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (491 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
KRT33AKeratin 33A; Belongs to the intermediate filament family. (404 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
SHC1SHC-transforming protein 1 isoform 3. (584 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
KRT9Keratin 9; Belongs to the intermediate filament family. (464 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (475 aa)
LOC694289Uncharacterized protein. (394 aa)
KRT31Keratin 31; Belongs to the intermediate filament family. (416 aa)
KRT34Keratin 34; Belongs to the intermediate filament family. (436 aa)
KRT33BKeratin 33B; Belongs to the intermediate filament family. (404 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PGRUncharacterized protein. (936 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
NCOA2Nuclear receptor coactivator. (1468 aa)
MMP9Uncharacterized protein. (707 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CALML5Calmodulin-like protein 5. (146 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
KRT37Keratin 37; Belongs to the intermediate filament family. (449 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (448 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (491 aa)
KRT19Keratin, type I cytoskeletal 19; Belongs to the intermediate filament family. (400 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform a. (354 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (603 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
SRCTyrosine-protein kinase. (644 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
HRASTransforming protein p21. (189 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (530 aa)
HSP90B1Endoplasmin. (804 aa)
GNAI1G protein subunit alpha i1. (422 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (522 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
KRT13IF rod domain-containing protein; Belongs to the intermediate filament family. (450 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (400 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CALML6Calmodulin like 6. (181 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (166 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
SOS2Uncharacterized protein. (1332 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SHC3Uncharacterized protein. (596 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GPER1G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...] (375 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MMP272 kDa type IV collagenase isoform a preproprotein. (660 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
SHC4Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
HSPA8Heat shock cognate 71 kDa protein isoform 1; Belongs to the heat shock protein 70 family. (646 aa)
KRT38Keratin 38; Belongs to the intermediate filament family. (452 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
RAF1Uncharacterized protein. (668 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PIK3R3Uncharacterized protein. (507 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
HBEGFEGF-like domain-containing protein. (214 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (372 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (469 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (583 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (468 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ATF4BZIP domain-containing protein. (351 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
HSPA1AUncharacterized protein; Belongs to the heat shock protein 70 family. (642 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
SLC29A1HATPase_c domain-containing protein. (1077 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
PRKCDProtein kinase C. (729 aa)
TFF1Trefoil factor 1. (84 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
NCOA3Nuclear receptor coactivator. (1421 aa)
SP1Uncharacterized protein. (845 aa)
HSP90AA1HATPase_c domain-containing protein. (733 aa)
GRM1Metabotropic glutamate receptor 1 isoform alpha. (1195 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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