STRINGSTRING
MAPK9 MAPK9 KRAS KRAS TNFRSF11A TNFRSF11A ELF5 ELF5 PIK3R2 PIK3R2 STAT5B STAT5B TH TH LHB LHB MAPK8 MAPK8 PIK3CA PIK3CA PRLR PRLR SHC1 SHC1 MAPK14 MAPK14 PIK3CB PIK3CB LHCGR LHCGR SOCS1 SOCS1 PIK3R1 PIK3R1 MAPK1 MAPK1 MAPK11 MAPK11 JAK2 JAK2 MAP2K1 MAP2K1 TNFSF11 TNFSF11 AKT3 AKT3 SRC SRC PRL PRL HRAS HRAS ESR2 ESR2 FOXO3 FOXO3 NFKB1 NFKB1 CSN2 CSN2 INS INS SLC2A2 SLC2A2 MAPK10 MAPK10 STAT3 STAT3 GRB2 GRB2 IRF1 IRF1 SOS2 SOS2 SHC3 SHC3 STAT5A STAT5A NRAS NRAS GCK GCK MAPK3 MAPK3 SHC4 SHC4 RELA RELA RAF1 RAF1 STAT1 STAT1 AKT2 AKT2 PIK3R3 PIK3R3 GSK3B GSK3B AKT1 AKT1 SOCS3 SOCS3 SOCS2 SOCS2 SOS1 SOS1 PIK3CD PIK3CD ESR1 ESR1 MAP2K2 MAP2K2 FOS FOS CGA CGA CISH CISH SOCS6 SOCS6 CCND1 CCND1 SOCS5 SOCS5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK9Mitogen-activated protein kinase. (424 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
TNFRSF11ATNF receptor superfamily member 11a. (615 aa)
ELF5Uncharacterized protein. (265 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
THTyrosine hydroxylase. (501 aa)
LHBLuteinizing hormone beta subunit. (141 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
SHC1SHC-transforming protein 1 isoform 3. (584 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (704 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SRCTyrosine-protein kinase. (644 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (228 aa)
HRASTransforming protein p21. (189 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation; Belongs to the nuclear hormone receptor family. NR3 subfamily. (530 aa)
FOXO3Forkhead box O3. (672 aa)
NFKB1Uncharacterized protein. (977 aa)
CSN2Beta-casein; Important role in determination of the surface properties of the casein micelles. (226 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
IRF1Interferon regulatory factor. (325 aa)
SOS2Uncharacterized protein. (1332 aa)
SHC3Uncharacterized protein. (596 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GCKPhosphotransferase. (466 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SHC4Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
RAF1Uncharacterized protein. (668 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PIK3R3Uncharacterized protein. (507 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (161 aa)
CISHCytokine-inducible SH2-containing protein isoform 2. (258 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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