STRINGSTRING
MAPK9 MAPK9 LEPR LEPR RXRB RXRB MAPK8 MAPK8 ACSL4 ACSL4 LEP LEP PRKAA2 PRKAA2 TRAF2 TRAF2 ACSBG1 ACSBG1 PRKAB2 PRKAB2 G6PC2 G6PC2 JAK2 JAK2 PRKAG1 PRKAG1 PPARA PPARA ADIPOR2 ADIPOR2 ACSBG2 ACSBG2 PRKAG3 PRKAG3 AKT3 AKT3 PRKCQ PRKCQ PCK2 PCK2 IRS2 IRS2 STK11 STK11 PCK1 PCK1 NFKBIE NFKBIE NFKBIB NFKBIB TTC33 TTC33 IKBKB IKBKB NFKB1 NFKB1 SLC2A4 SLC2A4 IKBKG IKBKG MAPK10 MAPK10 CHUK CHUK STAT3 STAT3 IRS1 IRS1 RXRA RXRA G6PC G6PC PTPN11 PTPN11 CPT1B CPT1B TNFRSF1A TNFRSF1A NFKBIA NFKBIA SLC2A1 SLC2A1 ACSL6 ACSL6 RELA RELA ADIPOQ ADIPOQ PRKAG2 PRKAG2 TNF TNF AKT2 AKT2 PPARGC1A PPARGC1A AKT1 AKT1 ACSL1 ACSL1 SOCS3 SOCS3 ADIPOR1 ADIPOR1 G6PC3 G6PC3 RXRG RXRG CAMKK2 CAMKK2 ACACB ACACB NPY NPY AGRP AGRP TRADD TRADD CD36 CD36 MTOR MTOR ACSL5 ACSL5 ACSL3 ACSL3 PRKAB1 PRKAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK9Mitogen-activated protein kinase. (424 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
RXRBRetinoid X receptor beta. (537 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ACSL4Long-chain-fatty-acid--CoA ligase 4 isoform 2. (711 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (758 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
ADIPOR2Adiponectin receptor 2. (406 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (637 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (739 aa)
PCK2Uncharacterized protein. (644 aa)
IRS2Insulin receptor substrate 2. (1394 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
NFKBIBNF-kappa-B inhibitor beta isoform a. (356 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
NFKB1Uncharacterized protein. (977 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
RXRARetinoid X receptor alpha. (620 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CPT1BCarnitine palmitoyltransferase 1B. (876 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (669 aa)
ACSL6AMP-binding domain-containing protein. (725 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PPARGC1APPARG coactivator 1 alpha. (818 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (724 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
RXRGRetinoid X receptor gamma. (474 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (666 aa)
ACACBAcetyl-CoA carboxylase beta. (2486 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (169 aa)
AGRPAgouti related neuropeptide. (132 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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