STRINGSTRING
PDE3B PDE3B PPP4C PPP4C PFKM PFKM CAMK2B CAMK2B PRMT1 PRMT1 GYS1 GYS1 PLCB1 PLCB1 CRTC2 CRTC2 ACACA ACACA LOC694289 LOC694289 PRKAA2 PRKAA2 LOC696959 LOC696959 PRKAB2 PRKAB2 PLCB3 PLCB3 G6PC2 G6PC2 PPP3CC PPP3CC LDHAL6A LDHAL6A PPP3CB PPP3CB PRKAG1 PRKAG1 GYS2 GYS2 PPARA PPARA CREB3L2 CREB3L2 CALML5 CALML5 CREB3L1 CREB3L1 PRKAG3 PRKAG3 CREB3L3 CREB3L3 AKT3 AKT3 SIK1 SIK1 PRKACG PRKACG PHKG2 PHKG2 CAMK2G CAMK2G LOC696854 LOC696854 PCK2 PCK2 PFKFB1 PFKFB1 FBP1 FBP1 PCK1 PCK1 PYGM PYGM TTC33 TTC33 SIRT1 SIRT1 FOXO1 FOXO1 LDHA LDHA LDHC LDHC PYGB PYGB CREB1 CREB1 SLC2A2 SLC2A2 CREB3L4 CREB3L4 ITPR2 ITPR2 PHKA2 PHKA2 CREB5 CREB5 ITPR3 ITPR3 PPP4R3A PPP4R3A CALML6 CALML6 PDHB PDHB ITPR1 ITPR1 ATF2 ATF2 G6PC G6PC CPT1B CPT1B GCK GCK CALML3 CALML3 GCGR GCGR PRKACA PRKACA SLC2A1 SLC2A1 PYGL PYGL PRKAG2 PRKAG2 AKT2 AKT2 ADCY2 ADCY2 PRKACB PRKACB PHKA1 PHKA1 PPARGC1A PPARGC1A PPP3R1 PPP3R1 PFKP PFKP AKT1 AKT1 GNAQ GNAQ LOC714548 LOC714548 PLCB4 PLCB4 SIK2 SIK2 PHKB PHKB CREB3 CREB3 CREBBP CREBBP FBP2 FBP2 PGAM2 PGAM2 PLCB2 PLCB2 G6PC3 G6PC3 CAMK2A CAMK2A ATF4 ATF4 LDHAL6B LDHAL6B ACACB ACACB LOC106992358 LOC106992358 LDHB LDHB GCG GCG CALM2 CALM2 EP300 EP300 CALM3 CALM3 PDHA2 PDHA2 PFKL PFKL PRKAB1 PRKAB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE3BPhosphodiesterase. (1117 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
GYS1Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family. (737 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CRTC2CREB-regulated transcription coactivator 2. (694 aa)
ACACAAcetyl-CoA carboxylase alpha. (2332 aa)
LOC694289Uncharacterized protein. (394 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
LOC696959Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (280 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform 1. (331 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa)
CALML5Calmodulin-like protein 5. (146 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (603 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SIK1Uncharacterized protein. (785 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, testis/liver isoform isoform 1; Belongs to the protein kinase superfamily. (406 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
LOC696854L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PCK2Uncharacterized protein. (644 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (522 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (467 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
SIRT1Sirtuin 1. (743 aa)
FOXO1Forkhead box O1. (655 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (343 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1186 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PPP4R3AProtein phosphatase 4 regulatory subunit 3A. (902 aa)
CALML6Calmodulin like 6. (181 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (377 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
CPT1BCarnitine palmitoyltransferase 1B. (876 aa)
GCKPhosphotransferase. (466 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (669 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1223 aa)
PPARGC1APPARG coactivator 1 alpha. (818 aa)
PPP3R1Uncharacterized protein. (171 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (797 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
LOC714548Uncharacterized protein. (234 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SIK2Salt inducible kinase 2. (1077 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (372 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
FBP2FBPase domain-containing protein; Belongs to the FBPase class 1 family. (345 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
ATF4BZIP domain-containing protein. (351 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
ACACBAcetyl-CoA carboxylase beta. (2486 aa)
LOC106992358Uncharacterized protein. (187 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (337 aa)
GCGGlucagon. (263 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
EP300Histone acetyltransferase p300. (2414 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (420 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (1016 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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