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ATP1B4 ATP1B4 SST SST CAMK2B CAMK2B SLC9A4 SLC9A4 PLCB1 PLCB1 GNAI3 GNAI3 KCNQ1 KCNQ1 LOC705671 LOC705671 LOC694289 LOC694289 PLCB3 PLCB3 MYLK MYLK CA2 CA2 KCNK2 KCNK2 CALML5 CALML5 ATP1A2 ATP1A2 EZR EZR SLC26A7 SLC26A7 GNAI2 GNAI2 PRKACG PRKACG SLC4A2 SLC4A2 ADCY4 ADCY4 ATP1B1 ATP1B1 CAMK2G CAMK2G CHRM3 CHRM3 GNAI1 GNAI1 PRKCG PRKCG KCNJ16 KCNJ16 CCKBR CCKBR ITPR2 ITPR2 ITPR3 ITPR3 ACTG1 ACTG1 ADCY8 ADCY8 CALML6 CALML6 KCNJ1 KCNJ1 HRH2 HRH2 ITPR1 ITPR1 ADCY3 ADCY3 ATP4A ATP4A ATP1A3 ATP1A3 ATP1A1 ATP1A1 ADCY5 ADCY5 CALML3 CALML3 PRKACA PRKACA ATP1B2 ATP1B2 SLC9A1 SLC9A1 KCNJ10 KCNJ10 ADCY2 ADCY2 PRKACB PRKACB GNAQ GNAQ PRKCB PRKCB MYLK2 MYLK2 PLCB4 PLCB4 ADCY6 ADCY6 MYLK4 MYLK4 PLCB2 PLCB2 ATP1B3 ATP1B3 ADCY9 ADCY9 CAMK2A CAMK2A ADCY1 ADCY1 PRKCA PRKCA KCNJ15 KCNJ15 CFTR CFTR GAST GAST SSTR2 SSTR2 ADCY7 ADCY7 KCNK10 KCNK10 KCNE2 KCNE2 CALM2 CALM2 CALM3 CALM3 ATP4B ATP4B KCNJ2 KCNJ2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
SSTSomatostatin preproprotein. (116 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (798 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
LOC705671Uncharacterized protein. (398 aa)
LOC694289Uncharacterized protein. (394 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
MYLKMyosin light chain kinase. (1914 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
CALML5Calmodulin-like protein 5. (146 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
EZREzrin. (598 aa)
SLC26A7Anion exchange transporter. (664 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
SLC4A2Anion exchange protein. (1238 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
GNAI1G protein subunit alpha i1. (422 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
KCNJ16Potassium voltage-gated channel subfamily J member 16. (458 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (450 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CALML6Calmodulin like 6. (181 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (389 aa)
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1086 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1031 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
KCNJ10ATP-sensitive inward rectifier potassium channel 10. (379 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MYLK2Myosin light chain kinase 2. (603 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
MYLK4Myosin light chain kinase family member 4. (541 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
KCNJ15Uncharacterized protein. (375 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1489 aa)
GASTGastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. (167 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (402 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
KCNK10Potassium two pore domain channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (543 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (291 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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