(48 nodes) Cholesterol metabolism network (Macaca mulatta)

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proteins of unknown 3D structure

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Your Input:
	STARD3	StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] (445 aa)
	APOA2	Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. (100 aa)
	SOAT2	O-acyltransferase. (526 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (498 aa)
	TSPO	Translocator protein isoform PBR. (169 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (151 aa)
	APOB	Apolipoprotein B. (4555 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (650 aa)
	ANGPTL8	Angiopoietin like 8. (198 aa)
	PLTP	Phospholipid transfer protein. (516 aa)
	LSM1	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1323 aa)
	APOH	Apolipoprotein H. (371 aa)
	APOA4	Apolipoprotein A4. (441 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	LPA	Apolipoprotein(a); Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. (589 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (500 aa)
	LIPG	Lipase G, endothelial type. (500 aa)
	APOC1	Cholesteryl ester transfer inhibitor protein; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. [...] (83 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (971 aa)
	VDAC3	Uncharacterized protein. (299 aa)
	SOAT1	O-acyltransferase. (550 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	SORT1	Sortilin. (878 aa)
	LDLR	Uncharacterized protein. (918 aa)
	LRP1	LDL receptor related protein 1. (4561 aa)
	LIPC	Lipase C, hepatic type. (523 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1297 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2266 aa)
	MYLIP	E3 ubiquitin-protein ligase MYLIP. (445 aa)
	VAPA	MSP domain-containing protein. (294 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (554 aa)
	TSPO2	Uncharacterized protein. (170 aa)
	CYP27A1	Uncharacterized protein; Belongs to the cytochrome P450 family. (584 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (320 aa)
	LRPAP1	LDL receptor related protein associated protein 1. (415 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (716 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	APOC3	Uncharacterized protein. (256 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
	VDAC2	Voltage dependent anion channel 2. (308 aa)
	VAPB	Vesicle-associated membrane protein-associated protein B/C isoform 1. (243 aa)
	LRP2	LDL receptor related protein 2. (4660 aa)
	VDAC1	Voltage-dependent anion-selective channel protein 1. (283 aa)
	APOC2	Uncharacterized protein. (184 aa)
	ANGPTL3	Angiopoietin like 3. (476 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (408 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCB11	ENSMMUP00000061741	ENSMMUP00000018185	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily B member 11.	0.513
ABCA1	ABCG5	ENSMMUP00000061741	ENSMMUP00000010587	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily G member 5.	0.441
ABCA1	ANGPTL3	ENSMMUP00000061741	ENSMMUP00000080274	ATP binding cassette subfamily A member 1.	Angiopoietin like 3.	0.599
ABCA1	APOA1	ENSMMUP00000061741	ENSMMUP00000021209	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.998
ABCA1	APOA2	ENSMMUP00000061741	ENSMMUP00000006019	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family.	0.831
ABCA1	APOB	ENSMMUP00000061741	ENSMMUP00000010112	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.859
ABCA1	APOC3	ENSMMUP00000061741	ENSMMUP00000074005	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.674
ABCA1	APOE	ENSMMUP00000061741	ENSMMUP00000048554	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.934
ABCA1	CD36	ENSMMUP00000061741	ENSMMUP00000072954	ATP binding cassette subfamily A member 1.	CD36 molecule; Belongs to the CD36 family.	0.698
ABCA1	CETP	ENSMMUP00000061741	ENSMMUP00000023122	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.818
ABCA1	CYP27A1	ENSMMUP00000061741	ENSMMUP00000068646	ATP binding cassette subfamily A member 1.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.497
ABCA1	CYP7A1	ENSMMUP00000061741	ENSMMUP00000008613	ATP binding cassette subfamily A member 1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.699
ABCA1	LIPC	ENSMMUP00000061741	ENSMMUP00000054111	ATP binding cassette subfamily A member 1.	Lipase C, hepatic type.	0.698
ABCA1	LIPG	ENSMMUP00000061741	ENSMMUP00000025049	ATP binding cassette subfamily A member 1.	Lipase G, endothelial type.	0.561
ABCA1	MYLIP	ENSMMUP00000061741	ENSMMUP00000065793	ATP binding cassette subfamily A member 1.	E3 ubiquitin-protein ligase MYLIP.	0.440
ABCA1	NPC1	ENSMMUP00000061741	ENSMMUP00000061643	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.705
ABCA1	PLTP	ENSMMUP00000061741	ENSMMUP00000013033	ATP binding cassette subfamily A member 1.	Phospholipid transfer protein.	0.701
ABCA1	SCARB1	ENSMMUP00000061741	ENSMMUP00000066313	ATP binding cassette subfamily A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.770
ABCA1	STARD3	ENSMMUP00000061741	ENSMMUP00000001794	ATP binding cassette subfamily A member 1.	StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...]	0.435
ABCB11	ABCA1	ENSMMUP00000018185	ENSMMUP00000061741	ATP binding cassette subfamily B member 11.	ATP binding cassette subfamily A member 1.	0.513