STRINGSTRING
CAMK2B CAMK2B TH TH GRIA4 GRIA4 DRD1 DRD1 GRIN2D GRIN2D GRIA3 GRIA3 HDAC1 HDAC1 PDYN PDYN LOC694289 LOC694289 CACNA1C CACNA1C PPP1CC PPP1CC PPP3CC PPP3CC PPP3CB PPP3CB GRIN3A GRIN3A CREB3L2 CREB3L2 PPP1CA PPP1CA CALML5 CALML5 ARC ARC CREB3L1 CREB3L1 GRIN2B GRIN2B MAOA MAOA CREB3L3 CREB3L3 DDC DDC SLC18A1 SLC18A1 PRKACG PRKACG PPP1CB PPP1CB CAMK2G CAMK2G PRKCG PRKCG SIRT1 SIRT1 CREB1 CREB1 CREB3L4 CREB3L4 GRIN1 GRIN1 CREB5 CREB5 CALML6 CALML6 GRIN2A GRIN2A ATF2 ATF2 CACNA1D CACNA1D GRIN3B GRIN3B SLC18A2 SLC18A2 ADCY5 ADCY5 CALML3 CALML3 PRKACA PRKACA ATF6B ATF6B HDAC2 HDAC2 PRKACB PRKACB FOSB FOSB GRIA1 GRIA1 PPP3R1 PPP3R1 GRIA2 GRIA2 PRKCB PRKCB CAMK4 CAMK4 CREB3 CREB3 SLC6A3 SLC6A3 CAMK2A CAMK2A MAOB MAOB ATF4 ATF4 PRKCA PRKCA GRIN2C GRIN2C FOS FOS JUN JUN CALM2 CALM2 CALM3 CALM3 PPP1R1B PPP1R1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
THTyrosine hydroxylase. (501 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (884 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PDYNProenkephalin-B preproprotein. (253 aa)
LOC694289Uncharacterized protein. (394 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
CALML5Calmodulin-like protein 5. (146 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
MAOAAmine oxidase. (969 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (603 aa)
DDCAromatic-L-amino-acid decarboxylase. (480 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
SIRT1Sirtuin 1. (743 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CALML6Calmodulin like 6. (181 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1042 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
FOSBBZIP domain-containing protein. (338 aa)
GRIA1Uncharacterized protein. (916 aa)
PPP3R1Uncharacterized protein. (171 aa)
GRIA2Uncharacterized protein. (883 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (372 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
MAOBAmine oxidase. (520 aa)
ATF4BZIP domain-containing protein. (351 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
PPP1R1BUncharacterized protein. (433 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.