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GABRP GABRP PDE3B PDE3B GNG13 GNG13 PDE1A PDE1A SLC32A1 SLC32A1 CACNA1A CACNA1A GNB4 GNB4 PDE4C PDE4C DRD1 DRD1 GNB3 GNB3 GNAI3 GNAI3 KCNJ3 KCNJ3 PDE4B PDE4B PDE3A PDE3A CACNA1B CACNA1B GABRA4 GABRA4 LOC694289 LOC694289 GABRE GABRE PDE7A PDE7A PDE4D PDE4D GABRR1 GABRR1 GNB5 GNB5 GABRB2 GABRB2 GABRR2 GABRR2 PDE8A PDE8A GNAO1 GNAO1 GNAI2 GNAI2 PRKACG PRKACG ADCY4 ADCY4 GNG5 GNG5 GNAI1 GNAI1 GABRA5 GABRA5 GABRG3 GABRG3 PRKCG PRKCG PDE4A PDE4A PDE7B PDE7B GABBR1 GABBR1 KCNJ6 KCNJ6 GABRR3 GABRR3 ADORA1 ADORA1 OPRM1 OPRM1 ADCY8 ADCY8 PDE1B PDE1B GNGT1 GNGT1 ADCY3 ADCY3 GNG11 GNG11 GNG3 GNG3 AGGF1 AGGF1 ADCY5 ADCY5 GRK2 GRK2 PRKACA PRKACA GABRB1 GABRB1 ADCY2 ADCY2 PRKACB PRKACB PRKCB PRKCB GABRQ GABRQ GABRA6 GABRA6 GABBR2 GABBR2 PDE10A PDE10A GRK3 GRK3 ADCY6 ADCY6 KCNJ5 KCNJ5 GNB1 GNB1 ARRB2 ARRB2 KCNJ9 KCNJ9 GNG7 GNG7 ADCY9 ADCY9 ADCY1 ADCY1 PDE11A PDE11A GABRD GABRD PRKCA PRKCA GABRA3 GABRA3 GNB2 GNB2 GABRG1 GABRG1 GRK5 GRK5 GABRA1 GABRA1 GABRB3 GABRB3 GRK6 GRK6 ADCY7 ADCY7 PDE1C PDE1C ARRB1 ARRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABRPGamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (460 aa)
PDE3BPhosphodiesterase. (1117 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PDE1APhosphodiesterase. (570 aa)
SLC32A1Vesicular inhibitory amino acid transporter. (525 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2411 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PDE4CPhosphodiesterase. (712 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
PDE4BPhosphodiesterase. (736 aa)
PDE3APhosphodiesterase. (1141 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2338 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (554 aa)
LOC694289Uncharacterized protein. (394 aa)
GABREGamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (506 aa)
PDE7APhosphodiesterase. (527 aa)
PDE4DPhosphodiesterase. (809 aa)
GABRR1Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (480 aa)
GNB5G protein subunit beta 5. (395 aa)
GABRB2Gamma-aminobutyric acid receptor subunit beta-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present [...] (512 aa)
GABRR2Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
PDE8APhosphodiesterase. (829 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform a. (354 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
ADCY4Adenylate cyclase 4. (1299 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI1G protein subunit alpha i1. (422 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
GABRG3Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (467 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
PDE4APhosphodiesterase. (886 aa)
PDE7BPhosphodiesterase. (505 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
GABRR3Gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (469 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (400 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PDE1BPhosphodiesterase. (538 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
AGGF1Phosphodiesterase. (1119 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GABRQGamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (632 aa)
GABRA6Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
PDE10APhosphodiesterase. (1059 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (711 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (469 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
ARRB2Arrestin beta 2. (575 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (468 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
PDE11APhosphodiesterase. (933 aa)
GABRDGamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
GABRA3Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (492 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GABRG1Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (478 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
GABRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3 isoform 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (473 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (560 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
PDE1CPhosphodiesterase. (793 aa)
ARRB1Arrestin beta 1. (529 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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