(38 nodes) Nicotine addiction network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

gene neighborhood

gene fusions

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	GABRP	Gamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (460 aa)
	SLC32A1	Vesicular inhibitory amino acid transporter. (525 aa)
	CACNA1A	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2411 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (884 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	CACNA1B	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2338 aa)
	GABRA4	Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (554 aa)
	GABRE	Gamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (506 aa)
	SLC17A7	Solute carrier family 17 member 7. (560 aa)
	GABRR1	Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (480 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
	SLC17A8	Solute carrier family 17 member 8. (589 aa)
	GABRB2	Gamma-aminobutyric acid receptor subunit beta-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present [...] (512 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	GABRR2	Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
	SLC17A6	Solute carrier family 17 member 6. (582 aa)
	CHRNA7	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity). (502 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
	GABRG3	Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (467 aa)
	LOC719678	Uncharacterized protein. (626 aa)
	GABRR3	Gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (469 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	CHRNA6	Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1042 aa)
	GABRB1	Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
	GRIA1	Uncharacterized protein. (916 aa)
	GRIA2	Uncharacterized protein. (883 aa)
	GABRQ	Gamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (632 aa)
	GABRA6	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
	GABRD	Gamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa)
	GABRA3	Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (492 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
	GABRG1	Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (478 aa)
	GABRA1	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3 isoform 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (473 aa)
	CHRNB2	Neuronal acetylcholine receptor subunit beta-2. (502 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA1A	CACNA1B	ENSMMUP00000004738	ENSMMUP00000012043	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	0.938
CACNA1B	CACNA1A	ENSMMUP00000012043	ENSMMUP00000004738	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	0.938
CACNA1B	GRIA1	ENSMMUP00000012043	ENSMMUP00000060453	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	Uncharacterized protein.	0.429
CHRNA6	CHRNA7	ENSMMUP00000048209	ENSMMUP00000029721	Cholinergic receptor nicotinic alpha 6 subunit.	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	0.600
CHRNA6	CHRNB2	ENSMMUP00000048209	ENSMMUP00000080762	Cholinergic receptor nicotinic alpha 6 subunit.	Neuronal acetylcholine receptor subunit beta-2.	0.550
CHRNA6	LOC719678	ENSMMUP00000048209	ENSMMUP00000038270	Cholinergic receptor nicotinic alpha 6 subunit.	Uncharacterized protein.	0.688
CHRNA7	CHRNA6	ENSMMUP00000029721	ENSMMUP00000048209	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Cholinergic receptor nicotinic alpha 6 subunit.	0.600
CHRNA7	CHRNB2	ENSMMUP00000029721	ENSMMUP00000080762	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Neuronal acetylcholine receptor subunit beta-2.	0.692
CHRNA7	GABRA6	ENSMMUP00000029721	ENSMMUP00000062360	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.429
CHRNA7	GRIN1	ENSMMUP00000029721	ENSMMUP00000040251	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Glutamate ionotropic receptor NMDA type subunit 1.	0.946
CHRNA7	GRIN2A	ENSMMUP00000029721	ENSMMUP00000046309	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Glutamate ionotropic receptor NMDA type subunit 2A.	0.926
CHRNA7	GRIN2C	ENSMMUP00000029721	ENSMMUP00000071066	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Glutamate ionotropic receptor NMDA type subunit 2C.	0.909
CHRNA7	GRIN2D	ENSMMUP00000029721	ENSMMUP00000007863	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Glutamate ionotropic receptor NMDA type subunit 2D.	0.911
CHRNA7	LOC719678	ENSMMUP00000029721	ENSMMUP00000038270	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	Uncharacterized protein.	0.608
CHRNB2	CHRNA6	ENSMMUP00000080762	ENSMMUP00000048209	Neuronal acetylcholine receptor subunit beta-2.	Cholinergic receptor nicotinic alpha 6 subunit.	0.550
CHRNB2	CHRNA7	ENSMMUP00000080762	ENSMMUP00000029721	Neuronal acetylcholine receptor subunit beta-2.	Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).	0.692
CHRNB2	LOC719678	ENSMMUP00000080762	ENSMMUP00000038270	Neuronal acetylcholine receptor subunit beta-2.	Uncharacterized protein.	0.980
CHRNB2	SLC17A6	ENSMMUP00000080762	ENSMMUP00000026804	Neuronal acetylcholine receptor subunit beta-2.	Solute carrier family 17 member 6.	0.421
GABRA1	GABRA3	ENSMMUP00000072520	ENSMMUP00000070695	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.721
GABRA1	GABRA4	ENSMMUP00000072520	ENSMMUP00000012458	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.747