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| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | FLNB | Filamin B. (2633 aa) |
| | TLR5 | Toll like receptor 5; Belongs to the Toll-like receptor family. (831 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | DYNLL1 | Dynein light chain. (89 aa) |
| | SNX18 | Sorting nexin 18. (693 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | CYTH2 | Uncharacterized protein. (552 aa) |
| | TLR6 | Toll-like receptor. (796 aa) |
| | MYL7 | Myosin light chain 7. (251 aa) |
| | LY96 | MD2 protein. (160 aa) |
| | MYL5 | Myosin light chain 5. (173 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | MYO6 | Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (951 aa) |
| | DYNC1I1 | WD_REPEATS_REGION domain-containing protein. (645 aa) |
| | FLNC | Filamin C. (2725 aa) |
| | ARPC3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa) |
| | MYL10 | Myosin light chain 10. (226 aa) |
| | SNX9 | Sorting nexin. (625 aa) |
| | DYNC1I2 | WD_REPEATS_REGION domain-containing protein. (655 aa) |
| | RHOJ | Rho-related GTP-binding protein RhoJ. (214 aa) |
| | MLKL | Mixed lineage kinase domain like pseudokinase. (470 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase. (335 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | EXOC7 | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (720 aa) |
| | PFN4 | Profilin; Belongs to the profilin family. (129 aa) |
| | LOC705671 | Uncharacterized protein. (398 aa) |
| | CASP4 | Caspase-4 isoform alpha; Belongs to the peptidase C14A family. (377 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | VPS41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa) |
| | CYFIP2 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | WASL | Neural Wiskott-Aldrich syndrome protein. (505 aa) |
| | KLC4 | Kinesin light chain 4. (637 aa) |
| | ANXA2 | Annexin. (357 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa) |
| | TLR9 | TIR domain-containing protein. (1032 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | DYNLT3 | Dynein light chain Tctex-type 3. (116 aa) |
| | CYTH1 | Cytohesin 1. (398 aa) |
| | FLNA | Filamin-A isoform 2. (2647 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | VPS39 | Uncharacterized protein. (886 aa) |
| | VPS18 | Vacuolar protein sorting-associated protein 18-like protein. (973 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa) |
| | DNM2 | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa) |
| | ELMO2 | Engulfment and cell motility 2. (732 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | SNX33 | Sorting nexin. (574 aa) |
| | TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa) |
| | KPNA1 | Importin subunit alpha; Functions in nuclear protein import. (538 aa) |
| | MYL9 | Myosin regulatory light polypeptide 9 isoform a. (172 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (471 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | KLC1 | Uncharacterized protein. (732 aa) |
| | M6PR | Mannose-6-phosphate receptor, cation dependent. (309 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | DYNC2H1 | Dynein cytoplasmic 2 heavy chain 1. (4314 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (575 aa) |
| | ACBD3 | Acyl-CoA binding domain containing 3. (528 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | DYNLT1 | Dynein light chain Tctex-type 1. (113 aa) |
| | CSE1L | Importin N-terminal domain-containing protein. (1000 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (589 aa) |
| | KPNA3 | Importin subunit alpha; Functions in nuclear protein import. (521 aa) |
| | VPS33A | Vacuolar protein sorting-associated protein 33A; Belongs to the STXBP/unc-18/SEC1 family. (596 aa) |
| | RAC1 | Uncharacterized protein. (212 aa) |
| | HRAS | Transforming protein p21. (189 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | KLC3 | Kinesin light chain 3. (504 aa) |
| | PIK3C2A | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa) |
| | RAB9A | Ras-related protein Rab-9A. (201 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (632 aa) |
| | ARPC2 | Actin related protein 2/3 complex subunit 2. (603 aa) |
| | ELMO1 | Engulfment and cell motility protein 1 isoform 1. (727 aa) |
| | HSP90B1 | Endoplasmin. (804 aa) |
| | RRAS | Ras-related protein R-Ras. (218 aa) |
| | STX10 | Syntaxin 10; Belongs to the syntaxin family. (324 aa) |
| | GSDMD | Gasdermin D. (529 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | MAP2K3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa) |
| | GCC2 | GRIP and coiled-coil domain containing 2. (1689 aa) |
| | DYNC2LI1 | Dynein cytoplasmic 2 light intermediate chain 1. (355 aa) |
| | ROCK2 | Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa) |
| | RPS3 | 40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | KLC2 | Kinesin light chain 2. (635 aa) |
| | DYNLRB1 | Dynein light chain roadblock; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. (96 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (910 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | CDC42 | Cell division control protein 42 homolog isoform 1. (191 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (399 aa) |
| | DYNLRB2 | Robl_LC7 domain-containing protein. (125 aa) |
| | DYNLL2 | Dynein light chain. (89 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | ACTG1 | Actin, cytoplasmic 2. (375 aa) |
| | BRK1 | BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | FBXO22 | Ubiquitin conjugating enzyme E2 Q2. (653 aa) |
| | PFN3 | Profilin; Belongs to the profilin family. (137 aa) |
| | RHOA | Ras homolog family member A. (209 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (908 aa) |
| | CYTH4 | Cytohesin-4. (394 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | NLRP3 | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] (1035 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1310 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | SKP1-2 | Uncharacterized protein; Belongs to the SKP1 family. (163 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | ARPC5L | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa) |
| | PKN1 | Protein kinase N1. (1013 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | TAB3 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3. (712 aa) |
| | MYL2 | Myosin light chain 2. (166 aa) |
| | CMTM4 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (628 aa) |
| | KPNA4 | Importin subunit alpha; Functions in nuclear protein import. (548 aa) |
| | EXOC5 | Exocyst complex component 5. (709 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (594 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | PLEKHM2 | Pleckstrin homology domain-containing family M member 2. (1019 aa) |
| | RAB5B | Ras-related protein Rab-5B isoform 1. (215 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | PODXL | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (522 aa) |
| | WASF3 | Wiskott-Aldrich syndrome protein family member 3. (502 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | TXN2 | Thioredoxin domain-containing protein. (169 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1403 aa) |
| | LOC114675515 | Uncharacterized protein. (152 aa) |
| | NCKAP1 | Nck-associated protein 1 isoform 2. (1134 aa) |
| | PIK3C2G | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa) |
| | RAB7A | RAB7A, member RAS oncogene family. (220 aa) |
| | PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (462 aa) |
| | S100A10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (227 aa) |
| | DYNC1H1 | Dynein cytoplasmic 1 heavy chain 1. (4685 aa) |
| | BAK1 | Uncharacterized protein. (261 aa) |
| | EXOC4 | Exocyst complex component 4 isoform a. (974 aa) |
| | PFN2 | Profilin; Belongs to the profilin family. (412 aa) |
| | RALA | Ras-related protein Ral-A. (206 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | RAB9B | Uncharacterized protein. (217 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa) |
| | BCL2 | BCL2 apoptosis regulator. (241 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa) |
| | AHNAK | Uncharacterized protein. (5912 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | FOS | V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa) |
| | PLEKHM1 | Pleckstrin homology and RUN domain containing M1. (1055 aa) |
| | RHOG | Rho-related GTP-binding protein RhoG. (191 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (195 aa) |
| | ARPC1A | Uncharacterized protein. (684 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | BIRC2 | Baculoviral IAP repeat-containing protein 2. (618 aa) |
| | SLC29A1 | HATPase_c domain-containing protein. (1077 aa) |
| | ARF1 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (217 aa) |
| | PFN1 | Profilin; Belongs to the profilin family. (140 aa) |
| | EXOC2 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1134 aa) |
| | ARF6 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (190 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1634 aa) |
| | PAK3 | Uncharacterized protein. (580 aa) |
| | FYCO1 | FYVE and coiled-coil domain containing 1. (1549 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | RAB7B | Ras-related protein Rab-7b. (199 aa) |
| | RHOH | Rho-related GTP-binding protein RhoH. (191 aa) |
| | MYL12A | Uncharacterized protein. (232 aa) |
| | HSP90AA1 | HATPase_c domain-containing protein. (733 aa) |
