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| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (185 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa) |
| | CD8A | CD8a molecule. (269 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1049 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha isoform 1. (561 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | LOC705671 | Uncharacterized protein. (398 aa) |
| | GIT2 | GIT ArfGAP 2. (740 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3. (192 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | WASL | Neural Wiskott-Aldrich syndrome protein. (505 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | ENSMMUP00000017083 | Ig-like domain-containing protein. (183 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (862 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa) |
| | ELMO2 | Engulfment and cell motility 2. (732 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | VAV2 | Guanine nucleotide exchange factor VAV2 isoform 1. (878 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (801 aa) |
| | ARHGEF28 | Rho guanine nucleotide exchange factor 28. (1704 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (786 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1883 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | RAC1 | Uncharacterized protein. (212 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
| | FYB1 | FYN binding protein 1. (839 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | ELMO1 | Engulfment and cell motility protein 1 isoform 1. (727 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | TICAM1 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | LIMK1 | LIM domain kinase 1 isoform 1. (647 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | ACTR3B | Actin-related protein 3B isoform 1; Belongs to the actin family. (418 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | MAP2K3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa) |
| | ROCK2 | Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | CDC42 | Cell division control protein 42 homolog isoform 1. (191 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | ACTG1 | Actin, cytoplasmic 2. (375 aa) |
| | LCK | Tyrosine-protein kinase. (567 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | RHOA | Ras homolog family member A. (209 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (860 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa) |
| | PKN2 | Protein kinase N2. (981 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | NLRP3 | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] (1035 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | WAS | WASP actin nucleation promoting factor. (503 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | BAIAP2 | Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4. (534 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | SKAP2 | Src kinase-associated phosphoprotein 2. (359 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2. (192 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | PKN1 | Protein kinase N1. (1013 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | CD8B | Ig-like domain-containing protein. (265 aa) |
| | WIPF3 | WAS/WASL interacting protein family member 3. (483 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2. (533 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (928 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (594 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | GSK3B | Glycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa) |
| | FN1 | Fibronectin isoform 1 preproprotein. (2477 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (462 aa) |
| | WIPF2 | WAS/WASL-interacting protein family member 2. (440 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (935 aa) |
| | LOC106999628 | Ig-like domain-containing protein. (242 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | LOC710149 | Ig-like domain-containing protein. (228 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa) |
| | FOS | V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa) |
| | ACTR3 | Actin-related protein 3; Belongs to the actin family. (418 aa) |
| | PIP5K1C | Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (718 aa) |
| | RHOG | Rho-related GTP-binding protein RhoG. (191 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (1128 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (195 aa) |
| | WIPF1 | WAS/WASL interacting protein family member 1. (544 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | WASF2 | WASP family member 2. (498 aa) |
| | ENSMMUP00000076578 | Ig-like domain-containing protein. (275 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type-1 beta isoform 2. (540 aa) |
| | ARF6 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (190 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | FCGR2A | Uncharacterized protein. (316 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (943 aa) |
