STRINGSTRING
COL1A1 COL1A1 LAMC3 LAMC3 GNA11 GNA11 PIK3R2 PIK3R2 PLCB1 PLCB1 CTSG CTSG PIK3CA PIK3CA PRDX1 PRDX1 LAMB1 LAMB1 COL4A6 COL4A6 COL4A1 COL4A1 CXCL1 CXCL1 SERPINB6 SERPINB6 PIK3CB PIK3CB CD14 CD14 LOC694289 LOC694289 LAMA1 LAMA1 PIK3R1 PIK3R1 TGFB3 TGFB3 PLCB3 PLCB3 ENSMMUP00000017083 ENSMMUP00000017083 COL4A4 COL4A4 LAMC1 LAMC1 TLR2 TLR2 SERPINB10 SERPINB10 CSF2 CSF2 GNA14 GNA14 C9 C9 CD1D CD1D PRKACG PRKACG IL1R2 IL1R2 VCL VCL IL12B IL12B LAMA2 LAMA2 COL4A2 COL4A2 C8A C8A IL12A IL12A IL10 IL10 TGFB1 TGFB1 PRKCG PRKCG NFKB1 NFKB1 CD1A CD1A CD1E CD1E TLR4 TLR4 C8G C8G LAMA3 LAMA3 COL3A1 COL3A1 ACTN1 ACTN1 SERPINB13 SERPINB13 IL6 IL6 PTK2 PTK2 LOC106994543 LOC106994543 ITGAM ITGAM LAMB2 LAMB2 ACTN4 ACTN4 LAMB4 LAMB4 PRKACA PRKACA RELA RELA COL4A5 COL4A5 TNF TNF PRKACB PRKACB PIK3R3 PIK3R3 C8B C8B COL1A2 COL1A2 RAB5B RAB5B LOC701920 LOC701920 GNAQ GNAQ PRKCB PRKCB PLCB4 PLCB4 GNA15 GNA15 LOC701315 LOC701315 LAMB3 LAMB3 FN1 FN1 CD1C CD1C IFNG IFNG RAB7A RAB7A MUC2 MUC2 CD1B CD1B LOC106999628 LOC106999628 LOC703390 LOC703390 PIK3CD PIK3CD PLCB2 PLCB2 ADCY1 ADCY1 PRKCA PRKCA CASP3 CASP3 CXCL8 CXCL8 GNAL GNAL COL4A3 COL4A3 ITGB2 ITGB2 ARG1 ARG1 HSPB1 HSPB1 IL1R1 IL1R1 CXCL3 CXCL3 ARG2 ARG2 SERPINB9 SERPINB9 LAMA4 LAMA4 IL1B IL1B RAB7B RAB7B LAMC2 LAMC2 NOS2 NOS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL1A1Collagen alpha-1(I) chain preproprotein. (1464 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRDX1Peroxiredoxin-1. (199 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
CXCL1C-X-C motif chemokine. (107 aa)
SERPINB6SERPIN domain-containing protein; Belongs to the serpin family. (395 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
LOC694289Uncharacterized protein. (394 aa)
LAMA1Uncharacterized protein. (528 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
ENSMMUP00000017083Ig-like domain-containing protein. (183 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
SERPINB10Serpin family B member 10; Belongs to the serpin family. (456 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
GNA14G protein subunit alpha 14. (355 aa)
C9Complement C9. (561 aa)
CD1DIg-like domain-containing protein. (337 aa)
PRKACGcAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa)
IL1R2Uncharacterized protein. (398 aa)
VCLVinculin. (1134 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (379 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
COL4A2Collagen type IV alpha 2 chain. (1739 aa)
C8AComplement C8 alpha chain. (584 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
NFKB1Uncharacterized protein. (977 aa)
CD1AIg-like domain-containing protein. (327 aa)
CD1ECD1e molecule. (437 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1466 aa)
ACTN1Actinin alpha 1. (914 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (400 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
LOC106994543SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1271 aa)
LAMB2Laminin subunit beta-2. (1798 aa)
ACTN4Actinin alpha 4. (911 aa)
LAMB4Laminin subunit beta 4. (1762 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa)
PIK3R3Uncharacterized protein. (507 aa)
C8BComplement C8 beta chain. (591 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
RAB5BRas-related protein Rab-5B isoform 1. (215 aa)
LOC701920SERPIN domain-containing protein; Belongs to the serpin family. (421 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
GNA15Uncharacterized protein. (414 aa)
LOC701315SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
FN1Fibronectin isoform 1 preproprotein. (2477 aa)
CD1CCD1c molecule. (332 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
RAB7ARAB7A, member RAS oncogene family. (220 aa)
MUC2Uncharacterized protein. (1920 aa)
CD1BCD1b molecule. (493 aa)
LOC106999628Ig-like domain-containing protein. (242 aa)
LOC703390C-X-C motif chemokine. (198 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
GNALUncharacterized protein. (450 aa)
COL4A3Collagen type IV alpha 3 chain. (1674 aa)
ITGB2Integrin beta. (911 aa)
ARG1Arginase. (322 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
CXCL3C-X-C motif chemokine. (318 aa)
ARG2Arginase. (417 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (515 aa)
LAMA4Laminin subunit alpha 4. (1832 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
RAB7BRas-related protein Rab-7b. (199 aa)
LAMC2Laminin subunit gamma 2. (1301 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1299 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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