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| | PTGER2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (185 aa) |
| | GNG13 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (412 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa) |
| | TSC2 | TSC complex subunit 2. (2057 aa) |
| | GNA11 | Guanine nucleotide-binding protein subunit alpha-11. (359 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (741 aa) |
| | GNB4 | Guanine nucleotide-binding protein subunit beta-4. (340 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | CCR3 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (355 aa) |
| | VEGFA | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (489 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (512 aa) |
| | PTGER1 | Prostaglandin E receptor 1. (581 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | BID | BH3 interacting domain death agonist. (310 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | LOC100426632 | C-C motif chemokine. (92 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | MAMU-F | Mamu class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system. (348 aa) |
| | TSC1 | TSC complex subunit 1. (1164 aa) |
| | LOC694289 | Uncharacterized protein. (394 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3. (192 aa) |
| | AKAP13 | A-kinase anchoring protein 13. (2899 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | STING1 | Stimulator of interferon protein. (379 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (511 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa) |
| | FIP1L1 | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | PTGER4 | Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (490 aa) |
| | GNA13 | G protein subunit alpha 13. (409 aa) |
| | CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1. (520 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | PTGER3 | Prostaglandin E receptor 3. (460 aa) |
| | GNB5 | G protein subunit beta 5. (395 aa) |
| | CALML5 | Calmodulin-like protein 5. (146 aa) |
| | CASP9 | Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | CREB3L1 | Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | ELK1 | ETS domain-containing protein Elk-1. (428 aa) |
| | ITGAV | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (573 aa) |
| | GNAO1 | Guanine nucleotide-binding protein G(O) subunit alpha isoform a. (354 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (603 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (350 aa) |
| | ADCY4 | Adenylate cyclase 4. (1299 aa) |
| | RAC1 | Uncharacterized protein. (212 aa) |
| | HRAS | Transforming protein p21. (189 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | GNAI1 | G protein subunit alpha i1. (422 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | LOC694631 | Uncharacterized protein. (190 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | TAPBP | TAP binding protein. (455 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | CXCL12 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa) |
| | ROCK2 | Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4. (395 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | LOC114672301 | ETS domain-containing protein. (488 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | HLA-E | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (357 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | LOC710751 | Uncharacterized protein. (189 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | STAT3 | Signal transducer and activator of transcription. (871 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | RHOA | Ras homolog family member A. (209 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | EGFR | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa) |
| | SOS2 | Uncharacterized protein. (1332 aa) |
| | LOC100423954 | C-C motif chemokine. (93 aa) |
| | ARHGEF11 | Rho guanine nucleotide exchange factor 11. (1562 aa) |
| | CALR | Calreticulin. (417 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 isoform 3. (2758 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | RB1 | Retinoblastoma-associated protein. (928 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | GNA12 | G protein subunit alpha 12. (463 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa) |
| | ADCY5 | Adenylate cyclase 5. (1263 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CALML3 | Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | PRKACA | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (431 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2. (192 aa) |
| | ATF6B | Activating transcription factor 6 beta. (711 aa) |
| | LOC100426537 | C-C motif chemokine. (67 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (594 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | PRKACB | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. (398 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (961 aa) |
| | GSK3B | Glycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa) |
| | PPP3R1 | Uncharacterized protein. (171 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | LOC710568 | Interferon alpha 16. (189 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | CREB3 | Cyclic AMP-responsive element-binding protein 3. (372 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1243 aa) |
| | LOC114675515 | Uncharacterized protein. (152 aa) |
| | LOC720132 | Major histocompatibility complex, class I, AG; Belongs to the MHC class I family. (339 aa) |
| | RHEB | Uncharacterized protein. (249 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (382 aa) |
| | CCL3 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) (By similarity). (92 aa) |
| | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa) |
| | TAP1 | Proteasome subunit beta 8. (907 aa) |
| | IFNA6 | Interferon alpha-6. (189 aa) |
| | CXCR2 | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (437 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (935 aa) |
| | BAK1 | Uncharacterized protein. (261 aa) |
| | GNG7 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa) |
| | ATF4 | BZIP domain-containing protein. (351 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | TAP2 | Uncharacterized protein. (843 aa) |
| | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (407 aa) |
| | CCR1 | C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. (355 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | IFNA10 | Uncharacterized protein. (189 aa) |
| | IFNA8 | Interferon alpha-8. (189 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa) |
| | CALM2 | Uncharacterized protein; Belongs to the calmodulin family. (204 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (569 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (580 aa) |
| | CALM3 | Calmodulin 3; Belongs to the calmodulin family. (194 aa) |
| | IFNA13 | Uncharacterized protein. (190 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) |
| | SP1 | Uncharacterized protein. (845 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | CCND1 | Uncharacterized protein; Belongs to the cyclin family. (303 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (943 aa) |
