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| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (476 aa) |
| | SAP30 | Histone deacetylase complex subunit SAP30. (220 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (907 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | RBPJL | Recombination signal binding protein for immunoglobulin kappa J region like. (517 aa) |
| | PSMC2 | 26S protease regulatory subunit 7 isoform 1; Belongs to the AAA ATPase family. (433 aa) |
| | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta. (160 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (597 aa) |
| | USP7 | Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1102 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | SEM1-2 | 26S proteasome complex subunit DSS1. (70 aa) |
| | CD44 | Phagocytic glycoprotein I. (742 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | BID | BH3 interacting domain death agonist. (310 aa) |
| | CD19 | CD19 molecule. (557 aa) |
| | IRF7 | Interferon regulatory factor 7. (504 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | PSMD4 | VWFA domain-containing protein. (400 aa) |
| | CD58 | Uncharacterized protein. (250 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (719 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | BLNK | B cell linker. (559 aa) |
| | MAMU-F | Mamu class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system. (348 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | ICAM1 | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (543 aa) |
| | CCNA2 | Cyclin-A2; Belongs to the cyclin family. (432 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | SAP30L | Histone deacetylase complex subunit SAP30L isoform 1. (184 aa) |
| | JAK3 | Janus kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (602 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha. (504 aa) |
| | DDX58 | Putative ATP-dependent RNA helicase DDX58. (925 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (488 aa) |
| | ENSMMUP00000017083 | Ig-like domain-containing protein. (183 aa) |
| | CR2 | Complement C3d receptor 2. (1091 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (574 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa) |
| | PSMC3 | 26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (439 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | MAVS | Mitochondrial antiviral-signaling protein isoform 1. (541 aa) |
| | PSMC4 | 26S protease regulatory subunit 6B isoform 1; Belongs to the AAA ATPase family. (418 aa) |
| | CD3D | Ig_4 domain-containing protein. (171 aa) |
| | CASP9 | Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | BCL2L11 | Uncharacterized protein. (292 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | MAMU-DPA | MHC class II antigen; Belongs to the MHC class II family. (260 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3. (534 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | CXCL10 | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa) |
| | RAC1 | Uncharacterized protein. (212 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1206 aa) |
| | NFKBIE | NFKB inhibitor epsilon. (361 aa) |
| | CIR1 | Corepressor interacting with RBPJ, 1. (589 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | LOC694631 | Uncharacterized protein. (190 aa) |
| | NFKBIB | NF-kappa-B inhibitor beta isoform a. (356 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | ITGAL | Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1169 aa) |
| | PSMC1 | 26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa) |
| | F7ALC4_MACMU | AAA domain-containing protein; Belongs to the AAA ATPase family. (360 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | TAPBP | TAP binding protein. (455 aa) |
| | MAMU-DMA | Ig-like domain-containing protein. (276 aa) |
| | POLK | DNA polymerase kappa. (868 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | MAP2K3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2516 aa) |
| | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | HLA-E | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (357 aa) |
| | CDK2 | Diacylglycerol kinase. (1053 aa) |
| | CCNA1 | Cyclin-A1 isoform a; Belongs to the cyclin family. (465 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1102 aa) |
| | LOC710751 | Uncharacterized protein. (189 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3. (790 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (315 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | STAT3 | Signal transducer and activator of transcription. (871 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | GADD45G | Cytokine-responsive protein CR6. (159 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | CALR | Calreticulin. (417 aa) |
| | RB1 | Retinoblastoma-associated protein. (928 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) |
| | SNW1 | SNW domain-containing protein 1. (536 aa) |
| | HLA-DRA | Mamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (378 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa) |
| | LYN | Tyrosine-protein kinase. (577 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) |
| | CD3G | CD3g molecule. (209 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | RBPJ | Uncharacterized protein. (500 aa) |
| | PSMD8 | CSN8_PSD8_EIF3K domain-containing protein. (364 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | STAT1 | Signal transducer and activator of transcription. (802 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | FCER2 | Fc fragment of IgE receptor II. (320 aa) |
| | CD247 | CD247 molecule. (224 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (594 aa) |
| | SKP2 | S-phase kinase-associated protein 2 isoform 1. (424 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | LOC710568 | Interferon alpha 16. (189 aa) |
| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | CD3E | CD3e molecule. (217 aa) |
| | PSMC5 | 26S protease regulatory subunit 8 isoform 1; Belongs to the AAA ATPase family. (406 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | LOC114675515 | Uncharacterized protein. (152 aa) |
| | LOC720132 | Major histocompatibility complex, class I, AG; Belongs to the MHC class I family. (339 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B. (198 aa) |
| | PSMD7 | MPN domain-containing protein. (323 aa) |
| | IRF9 | Interferon regulatory factor 9. (455 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | ENTPD3 | Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (534 aa) |
| | TYK2 | Tyrosine-protein kinase. (1196 aa) |
| | TAP1 | Proteasome subunit beta 8. (907 aa) |
| | IFNA6 | Interferon alpha-6. (189 aa) |
| | BAK1 | Uncharacterized protein. (261 aa) |
| | LOC106999628 | Ig-like domain-containing protein. (242 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | LOC710149 | Ig-like domain-containing protein. (228 aa) |
| | BCL2 | BCL2 apoptosis regulator. (241 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | TAP2 | Uncharacterized protein. (843 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa) |
| | IFNA10 | Uncharacterized protein. (189 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1319 aa) |
| | IFNA8 | Interferon alpha-8. (189 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | LOC114669810 | Ig-like domain-containing protein; Belongs to the MHC class II family. (266 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | MAMU-DOA | Ig-like domain-containing protein; Belongs to the MHC class II family. (342 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (287 aa) |
| | ENSMMUP00000076578 | Ig-like domain-containing protein. (275 aa) |
| | IFNA13 | Uncharacterized protein. (190 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) |
| | ISG15 | Ubiquitin-like protein ISG15. (165 aa) |
| | HES1 | Transcription factor HES-1. (280 aa) |
| | IFNAR2 | Uncharacterized protein. (684 aa) |
| | CCND1 | Uncharacterized protein; Belongs to the cyclin family. (303 aa) |
