STRINGSTRING
ARNT2 ARNT2 BMI1 BMI1 LOC695427-2 LOC695427-2 SIX4 SIX4 IGF1 IGF1 MPO MPO WNT16 WNT16 NCOR1 NCOR1 PML PML FLI1 FLI1 KDM6A KDM6A BCL2A1 BCL2A1 GADD45B GADD45B CD40 CD40 RXRB RXRB ELK4 ELK4 ATM ATM MMP3 MMP3 PDGFA PDGFA ITGB7 ITGB7 LOC106995824 LOC106995824 IL2RB IL2RB KMT2A KMT2A MLLT1 MLLT1 BCL2L1 BCL2L1 MET MET ZBTB16 ZBTB16 RUNX1T1 RUNX1T1 LMO2 LMO2 ZBTB17 ZBTB17 TP53 TP53 GRIA3 GRIA3 SIN3A SIN3A LDB1 LDB1 DDX5 DDX5 ELANE ELANE CCNA2 CCNA2 WT1 WT1 PLAU PLAU HDAC1 HDAC1 CD14 CD14 TGFBR2 TGFBR2 REL REL ASPSCR1 ASPSCR1 MEIS1 MEIS1 PBX1 PBX1 NR4A3 NR4A3 HHEX HHEX IGF1R IGF1R NTRK1 NTRK1 RARA RARA ENSMMUP00000017083 ENSMMUP00000017083 JUP JUP HOXA9 HOXA9 HOXA10 HOXA10 ETV5 ETV5 PBX3 PBX3 IGFBP3 IGFBP3 AFF1 AFF1 MDM2 MDM2 GZMB GZMB MYC MYC NGFR NGFR SPI1 SPI1 LOC699443 LOC699443 MMP9 MMP9 IL3 IL3 CSF2 CSF2 PAX7 PAX7 TLX1 TLX1 JMJD1C JMJD1C DEFA4 DEFA4 SMAD1 SMAD1 DEFA1B DEFA1B PER2 PER2 CDKN2C CDKN2C FUS FUS HPGD HPGD IL1R2 IL1R2 FLT1 FLT1 NXPE3 NXPE3 FUT8 FUT8 PTCRA PTCRA POLK POLK NFKB1 NFKB1 BMP2K BMP2K PROM1 PROM1 ZEB1 ZEB1 CCNT2 CCNT2 FOXO1 FOXO1 MEN1 MEN1 FCGR1A FCGR1A GADD45A GADD45A LOC708657 LOC708657 CCNA1 CCNA1 SUPT3H SUPT3H MEF2C MEF2C ETV4 ETV4 PAX5 PAX5 LYL1 LYL1 ERG ERG GADD45G GADD45G TFE3 TFE3 RXRA RXRA ID2 ID2 HMGA2 HMGA2 IL6 IL6 PTK2 PTK2 PAX3 PAX3 CEBPB CEBPB DOT1L DOT1L LOC710748 LOC710748 TAF15 TAF15 CD86 CD86 ITGAM ITGAM EYA1 EYA1 CSF1R CSF1R NSD2 NSD2 RELA RELA LOC114669830 LOC114669830 ETV1 ETV1 MITF MITF TRAF1 TRAF1 HDAC2 HDAC2 ETV7 ETV7 PLAT PLAT RTD1A RTD1A PRCC PRCC PRRG1 PRRG1 TCF3 TCF3 DEFA6 DEFA6 HOXA11 HOXA11 LOC114675515 LOC114675515 H3-4 H3-4 CDKN1B CDKN1B DUSP6 DUSP6 ATF1 ATF1 BAK1 BAK1 FEV FEV LOC106999628 LOC106999628 LOC693939 LOC693939 TMPRSS2 TMPRSS2 LOC710149 LOC710149 LOC718280 LOC718280 RXRG RXRG DDIT3 DDIT3 CDK14 CDK14 LOC709052 LOC709052 BIRC3 BIRC3 CCNT1 CCNT1 CXCL8 CXCL8 KLF3 KLF3 CDK9 CDK9 BIRC2 BIRC2 MLLT3 MLLT3 RUNX1 RUNX1 TLX3 TLX3 PPARG PPARG RTD1B RTD1B ENSMMUP00000076578 ENSMMUP00000076578 MAF MAF MYCN MYCN SIX1 SIX1 SPINT1 SPINT1 CDKN1A CDKN1A SLC45A3 SLC45A3 CEBPE CEBPE SP1 SP1 ETV6 ETV6 BCL11B BCL11B BCL6 BCL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (711 aa)
BMI1RING-type domain-containing protein. (469 aa)
LOC695427-2Histone H3; Belongs to the histone H3 family. (136 aa)
SIX4SIX homeobox 4. (772 aa)
IGF1Insulin like growth factor 1. (208 aa)
MPOMyeloperoxidase. (745 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
PMLPromyelocytic leukemia protein. (882 aa)
FLI1Fli-1 proto-oncogene, ETS transcription factor. (475 aa)
KDM6ALysine demethylase 6A. (1489 aa)
BCL2A1Bcl-2-related protein A1 isoform 1. (175 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa)
RXRBRetinoid X receptor beta. (537 aa)
ELK4ETS domain-containing protein Elk-4 isoform a. (431 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (807 aa)
LOC106995824KRAB-related domain-containing protein. (188 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4001 aa)
MLLT1MLLT1 super elongation complex subunit. (557 aa)
BCL2L1Bcl-2-like protein 1 isoform 1. (233 aa)
METUncharacterized protein. (1381 aa)
ZBTB16Uncharacterized protein. (673 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (615 aa)
LMO2Uncharacterized protein. (222 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17 isoform 2. (800 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
LDB1LIM domain-binding protein 1 isoform 1. (411 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (432 aa)
WT1WT1 transcription factor. (517 aa)
PLAUPlasminogen activator, urokinase. (430 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RELREL proto-oncogene, NF-kB subunit. (616 aa)
ASPSCR1ASPSCR1 tether for SLC2A4, UBX domain containing. (617 aa)
MEIS1Meis homeobox 1. (465 aa)
PBX1Pre-B-cell leukemia transcription factor 1 isoform 1. (430 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (717 aa)
HHEXHematopoietically expressed homeobox. (270 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
ENSMMUP00000017083Ig-like domain-containing protein. (183 aa)
JUPUncharacterized protein. (744 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
HOXA10Homeobox A10. (410 aa)
ETV5ETS translocation variant 5. (510 aa)
PBX3Pre-B-cell leukemia transcription factor 3 isoform 1. (434 aa)
IGFBP3Insulin-like growth factor-binding protein 3 isoform b. (291 aa)
AFF1AF4/FMR2 family member 1. (1221 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (315 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
NGFRNerve growth factor receptor. (427 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
LOC699443Histone H3; Belongs to the histone H3 family. (136 aa)
MMP9Uncharacterized protein. (707 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. (143 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
PAX7Paired box 7. (503 aa)
TLX1T cell leukemia homeobox 1. (330 aa)
JMJD1CJumonji domain containing 1C. (2536 aa)
DEFA4DEFENSIN domain-containing protein. (94 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
DEFA1BNeutrophil defensin 1; Has bacteriostatic activity against Gram-positive bacteria S.aureus and L.monocytogenes and Gram-negative bacterium E.coli and antifungal activity against C.neoformans. Has microbicidial activity against Gram-positive bacteria S.aureus and L.monocytogenes. (96 aa)
PER2Period circadian regulator 2. (1254 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
FUSTripartite motif containing 72. (534 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
IL1R2Uncharacterized protein. (398 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1474 aa)
NXPE3ANK_REP_REGION domain-containing protein. (930 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
PTCRAUncharacterized protein. (281 aa)
POLKDNA polymerase kappa. (868 aa)
NFKB1Uncharacterized protein. (977 aa)
BMP2KBMP2 inducible kinase. (1144 aa)
PROM1Prominin 1. (855 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1126 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (709 aa)
FOXO1Forkhead box O1. (655 aa)
MEN1Menin isoform 2. (610 aa)
FCGR1AFCGRI variant 1. (357 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
LOC708657KRAB-related domain-containing protein. (188 aa)
CCNA1Cyclin-A1 isoform a; Belongs to the cyclin family. (465 aa)
SUPT3HUncharacterized protein. (328 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
ETV4ETS variant 4. (684 aa)
PAX5Paired box 5. (407 aa)
LYL1LYL1 basic helix-loop-helix family member. (293 aa)
ERGETS transcription factor ERG. (486 aa)
GADD45GCytokine-responsive protein CR6. (159 aa)
TFE3Transcription factor E3. (575 aa)
RXRARetinoid X receptor alpha. (620 aa)
ID2Inhibitor of DNA binding 2. (203 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
PAX3Paired box 3. (484 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1774 aa)
LOC710748Histone H3; Belongs to the histone H3 family. (136 aa)
TAF15TATA-box binding protein associated factor 15. (575 aa)
CD86CD86 molecule. (417 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1271 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1045 aa)
NSD2Uncharacterized protein. (1362 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
LOC114669830Histone H3; Belongs to the histone H3 family. (136 aa)
ETV1ETS domain-containing protein. (491 aa)
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
TRAF1TNF receptor-associated factor. (416 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ETV7ETS variant 7. (528 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
RTD1ARhesus theta defensin-1/3 subunit A; RTD-1 and RTD-3 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram- negative bacteria S.typhimurium and E.coli ML35, and the fungi C.albicans 16820 and C.neoformans 271A; Belongs to the alpha-defensin family. Theta subfamily. (76 aa)
PRCCUncharacterized protein. (511 aa)
PRRG1Tetraspanin. (396 aa)
TCF3Transcription factor 3. (654 aa)
DEFA6Defensin, alpha 6. (100 aa)
HOXA11Homeobox A11. (311 aa)
LOC114675515Uncharacterized protein. (152 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (270 aa)
BAK1Uncharacterized protein. (261 aa)
FEVFEV transcription factor, ETS family member. (238 aa)
LOC106999628Ig-like domain-containing protein. (242 aa)
LOC693939Histone H3; Belongs to the histone H3 family. (136 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa)
LOC710149Ig-like domain-containing protein. (228 aa)
LOC718280Histone domain-containing protein. (136 aa)
RXRGRetinoid X receptor gamma. (474 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
CDK14Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (469 aa)
LOC709052KRAB-related domain-containing protein. (188 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (728 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
KLF3Basic krueppel-like factor. (345 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
MLLT3MLLT3 super elongation complex subunit. (600 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
TLX3T cell leukemia homeobox 3. (338 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RTD1BRhesus theta defensin-1/2 subunit B; RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram- negative bacterium S.typhimurium, and the fungi C.albicans 16820 and C.neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E.coli ML35; Belongs to the alpha-defensin family. Theta subfamily. (76 aa)
ENSMMUP00000076578Ig-like domain-containing protein. (275 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (403 aa)
MYCNMYCN proto-oncogene, bHLH transcription factor. (555 aa)
SIX1SIX homeobox 1. (284 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (667 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
SP1Uncharacterized protein. (845 aa)
ETV6Uncharacterized protein. (457 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
BCL6Uncharacterized protein. (735 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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