STRINGSTRING
AXIN1 AXIN1 MAPK9 MAPK9 KRAS KRAS AREG AREG PIK3R2 PIK3R2 GADD45B GADD45B MAPK8 MAPK8 PIK3CA PIK3CA RPS6KB2 RPS6KB2 TP53 TP53 PIK3CB PIK3CB TGFBR2 TGFBR2 EGF EGF RAC3 RAC3 PIK3R1 PIK3R1 TGFB3 TGFB3 MAPK1 MAPK1 DCC DCC MYC MYC LOC710997 LOC710997 MAP2K1 MAP2K1 CASP9 CASP9 SMAD4 SMAD4 BCL2L11 BCL2L11 AKT3 AKT3 TCF7L1 TCF7L1 RAC1 RAC1 HRAS HRAS MLH1 MLH1 TCF7L2 TCF7L2 MSH6 MSH6 TGFB1 TGFB1 POLK POLK RALB RALB MSH2 MSH2 F6SS94_MACMU F6SS94_MACMU LOC106995524 LOC106995524 GADD45A GADD45A SMAD3 SMAD3 MAPK10 MAPK10 BRAF BRAF GRB2 GRB2 MSH3 MSH3 RHOA RHOA SMAD2 SMAD2 TGFA TGFA GADD45G GADD45G EGFR EGFR SOS2 SOS2 BIRC5 BIRC5 NRAS NRAS TGFBR1 TGFBR1 MAPK3 MAPK3 APC2 APC2 RAC2 RAC2 RAF1 RAF1 LOC710293 LOC710293 APPL1 APPL1 AKT2 AKT2 PIK3R3 PIK3R3 GSK3B GSK3B AKT1 AKT1 CTNNB1 CTNNB1 LOC114675515 LOC114675515 SOS1 SOS1 BAK1 BAK1 BAD BAD RALA RALA PIK3CD PIK3CD MAP2K2 MAP2K2 APC APC BCL2 BCL2 CASP3 CASP3 FOS FOS CYCS CYCS MTOR MTOR ARAF ARAF JUN JUN AXIN2 AXIN2 CDKN1A CDKN1A CCND1 CCND1 EREG EREG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AXIN1Axin 1. (867 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
AREGAmphiregulin. (252 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (512 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
DCCDCC netrin 1 receptor. (1447 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
LOC710997Ras-GEF domain-containing protein. (490 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CASP9Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2L11Uncharacterized protein. (292 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
RAC1Uncharacterized protein. (212 aa)
HRASTransforming protein p21. (189 aa)
MLH1MutL homolog 1. (756 aa)
TCF7L2Transcription factor 7 like 2. (632 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
POLKDNA polymerase kappa. (868 aa)
RALBUncharacterized protein. (286 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
F6SS94_MACMURas-GEF domain-containing protein. (447 aa)
LOC106995524Ras-GEF domain-containing protein. (553 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
RHOARas homolog family member A. (209 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (166 aa)
GADD45GCytokine-responsive protein CR6. (159 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
SOS2Uncharacterized protein. (1332 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform 1. (142 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
APC2APC regulator of WNT signaling pathway 2. (2403 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
RAF1Uncharacterized protein. (668 aa)
LOC710293Ras-GEF domain-containing protein. (553 aa)
APPL1Uncharacterized protein. (846 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PIK3R3Uncharacterized protein. (507 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CTNNB1Catenin beta-1. (781 aa)
LOC114675515Uncharacterized protein. (152 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
BAK1Uncharacterized protein. (261 aa)
BADBcl2 antagonist of cell death. (167 aa)
RALARas-related protein Ral-A. (206 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
AXIN2Axin 2. (862 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
EREGProepiregulin. (169 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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